Simon Woelfel
@SimonWoelfel
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PhD student in the Stecher lab @LMU_Muenchen. Interested in bacterial evolution, inflammatory diseases, and all things microbiome.
Joined October 2022
Nothing in biology makes sense except in the light of context! Check out our new review on contextual factors shaping the mechanisms of intestinal colonization resistance. @marta_tita15 (co-first) @baerboletta
@cellhostmicrobe
Intestinal colonization resistance in the context of environmental, host & microbial determinants @baerboletta & Co examine interplay between #microbes &their host that protects against infection & is influenced by metabolic, immune & environmental factors https://t.co/GwnqVb7Ep2
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Microbial metabolite indole-3-propionic acid promotes mitochondrial respiration to suppress pro-inflammatory T cells, alleviating inflammatory bowel disease #IBD in humans and mice @h_sokol @NatMetabolism @Cyaner_Li
@Inserm 🇫🇷 https://t.co/PbNg3CfnGW
https://t.co/K98iiRd0xY
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Our last paper on gut microbiota-derived cadaverine in intestinal inflammation is out in @cellhostmicrobe ! and it is FREE! https://t.co/KI5tjWSjGN Congratulations to @formigadc and thanks to all the contributors! @MedecineSU @Inserm @crsa_paris @APHP @INRAE_IDF
#Thread 1/22
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Professorship in Microbial Genetics @ University of Göttingen. Don't miss this chance to become my colleague! https://t.co/Swchaf3IiC
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Please retweet! We hire PIs working in microbiome+metabolism+cancer+allergies+autoimmunity+neurological+infectious diseases. We offer SPF-, gnotobiotic- and wildling-models + top notch lab and equip. (e.g. SONY ID7000/10X Xenium/MACSima). Contact: stephan.rosshart@uk-erlangen.de
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New paper! Combining epidemiology and experiments uncovers surprising drug-host-microbiome-pathogen interactions. Congrats @Aman_Kr25 @RobynTamblyn and the rest of the team. https://t.co/A6vr7JQx9r
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Join us ! Open #Postdoc position in my lab (Paris, France), to work on the Role of the Gut #microbiota in Host Cells Energy Metabolism in Health and #IBD see details here 🔽🔽🔽🔽 https://t.co/nUv6slIV6k please RT
euraxess.ec.europa.eu
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Please RT, our latest work just published @NatureComms „ONE MICROBIOTA TO RULE THEM ALL“ https://t.co/bweLHHtbeb A big THANK YOU to the entire team of great scientists! #wildlings
https://t.co/V3lF3xHQgP
@UniFAU @Hornegger #HTA
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Please RT! Looking for PIs working in microbiome, metabolism, cancer, allergies, autoimmunity, neurological and infectious diseases. We offer SPF-, gnotobiotic- and wildling-models + top notch equip., e.g. SONY ID7000, 10X Xenium, MACSima. Contact: stephan.rosshart@uk-erlangen.de
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The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.@FabiAlexFischer
science.org
TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.
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Monosaccharides drive Salmonella gut colonization in a context-dependent or -independent manner | Nature Communications
nature.com
Nature Communications - Here, Schubert et al. investigate the metabolic requirements for Salmonella Typhimurium colonization using a barcoded mutant pool across five different mouse models with...
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IBD-associated small molecules @MoamenElmassry @donia_lab ID microbiome-encoded biosynthetic gene clusters that are enriched in Crohn’s disease patients & the small molecules they produce, which exacerbate disease when introduced to mouse models of colitis https://t.co/a3X3LEeQjB
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Researchers at the Kennedy Institute @KIROxford have mapped the cellular dynamics of Inflammatory Bowel Disease and discovered why some patients benefit from anti-TNF treatment while others do not.
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We are looking for a postdoc in bioinformatics interested in broad questions about the ecology and evolution of host-associated microbiomes using social bees as model. Please share with potential candidates and if interested apply here:
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What a pleasure to see our bacterial-MERFISH work out in @ScienceMagazine this week! Congratulations to the talented team that led this effort--Ari, Yuanyou, and Nana! https://t.co/JN0G6AKp3P.
science.org
Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been...
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Please retweet. We are honored with the cover of Jan 2025 issue @TrendsImmuno
https://t.co/Df441HcTni! We are all „Born to be Wild“! https://t.co/KbPNeCrZmr
@CellPressNews #wildlings
https://t.co/zDKitCyUbj
https://t.co/mGgR3Ccxs7
@UniFAU @Hornegger #HTA
science.org
Allergen exposure in wildling mice induces robust de novo responses and activates an endogenous memory TH2 cell pool.
Read the @TrendsImmuno Jan issue!! #Skinmacrophages, #EBV & #Bcell #metabolism, wild mice & natural #microbiota in research, biomolecular #condensates & #host #pathogen interactions, #Brainmacrophages in #vasculature, targeting ICI #toxicities, & more!! https://t.co/zHdMHN5ptL
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Yersiniabactin promotes profibrotic macrophages in Crohn’s E. coli yersiniabactin sequesters zinc & stabilizes HIF-1α in macrophages, promoting profibrotic gene expression. HIF-1α+ Macs are abundant in fibrotic strictures of CD patients @ArthurTorchio
https://t.co/9girxdsEjF
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Glial-immune interactions in barrier organs are reviewed by @franzeprogatzky and colleagues: https://t.co/YOwUMD9KRH
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The gut microbiome signature from different diets in >20,000 individuals. Red meat intake correlated with reduced cardiometabolic health; the opposite for plant-based foods or in omnivores with enriched plant-based intake https://t.co/IWEOqUMcxB
@NatureMicrobiol @nsegata
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Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn’s disease https://t.co/vCr453LRhf
@cellhostmicrobe @ArthurTorchio
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Please RT, because we are all „Born to be Wild“ and it really is time to think about reproducibility in biomedical research! A big THANK YOU to the brilliant Philipp Bruno and Thomas Schüler! @TrendsImmuno @CellPressNews #wildlings
https://t.co/zDKitCyUbj
@UniFAU @Hornegger #HTA
Born to be wild: utilizing natural microbiota for reliable biomedical research https://t.co/eNX1KhFofb
#immunology
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