Huiluo Cao 曹慧荦
@hlcao
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microbial genomics and evolution, antibiotic resistance, bioinformatics, Pseudomonas aeruginosa, pneumococcus, human microbioa, @hkuniversity
Hong Kong
Joined May 2011
We launched a BMC Genomic Data Collection that seeks to attract advances in the field of genomics of antibiotic-producing microorganisms, as well as other genomics work. Welcome any interested to contribute. https://t.co/6Lru8as4ST
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Circulation of Salmonella spp. between humans, animals and the environment in animal-owning households in Malawi | Nature Communications
nature.com
Nature Communications - In this work, Wilson et al., examined sharing of Salmonella between humans, animals and the environment using household samples from Malawi. They revealed an interconnected...
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Multimodal learning enables chat-based exploration of single-cell data | Nature Biotechnology
nature.com
Nature Biotechnology - CellWhisperer uses multimodal learning of transcriptomes and text to answer questions about single-cell RNA-sequencing data.
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Strain displacement in microbiomes via ecological competition | Nature Microbiology
nature.com
Nature Microbiology - Mathematical modelling and experimental tests reveal principles that govern displacement of a resident strain by an invader in microbial communities.
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Accurate profiling of microbial communities for shotgun metagenomic sequencing with Meteor2 | Microbiome | Full Text
microbiomejournal.biomedcentral.com
Background The characterization of complex microbial communities is a critical challenge in microbiome research, as it is essential for understanding the intricate relationships between microorgani...
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Genome sequencing for prevention of health-care-associated bacterial infections | Nature Reviews Microbiology
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PGAP2: A comprehensive toolkit for prokaryotic pan-genome analysis based on fine-grained feature networks | Nature Communications
nature.com
Nature Communications - Prokaryotic pan-genome analysis is crucial for understanding microbial diversity, however current analytical methods often struggle to balance accuracy and computational...
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Integrated Tn-seq and MAGE-assisted rapid genome engineering targeting in Escherichia coli: Trends in Biotechnology
cell.com
We developed an integrated platform that combines in situ transposon mutagenesis, biosensor-guided selection, and multiplex automated genome engineering. This approach significantly accelerates the...
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Multifunctionally diverse alkaline phosphatases of Alteromonas drive the phosphorus cycle in the ocean | Nature Communications
nature.com
Nature Communications - This study shows that Alteromonas is a key driver of phosphorus recycling in the ocean and that its alkaline phosphatases are multifunctional—with different families...
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Strain displacement in microbiomes via ecological competition | Nature Microbiology
nature.com
Nature Microbiology - Mathematical modelling and experimental tests reveal principles that govern displacement of a resident strain by an invader in microbial communities.
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Streptococcus pneumoniae epidemiology, pathogenesis and control | Nature Reviews Microbiology
nature.com
Nature Reviews Microbiology - In this Review, Henriques-Normark and colleagues explore recent insights into Streptococcus pneumoniae epidemiology, clinical disease and pathogenesis, as well as new...
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Genetic population structure of Haemophilus influenzae at local and global scales | Nature Microbiology
nature.com
Nature Microbiology - Large-scale sequencing and population genomic analyses reveal frequent transmission, a highly admixed global population structure and evidence of pervasive negative selection...
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Growth-coupled microbial biosynthesis of the animal pigment xanthommatin | Nature Biotechnology
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Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation | Science
science.org
Enteric neurons are essential regulators of intestinal physiology, yet their responses to varying microbial and immune environments along the intestinal tract and or during challenges remain poorly...
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A high-quality genomic catalog of the human oral microbiome broadens its phylogeny and clinical insights: Cell Host & Microbe
cell.com
Oral microbiome shows rising importance in human health. Cha et al. present the human reference oral microbiome (HROM), comprising 72,641 high-quality genomes from 3,426 species, including 2,019...
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A full life cycle biological clock based on routine clinical data and its impact in health and diseases | Nature Medicine
nature.com
Nature Medicine - The biological clock model LifeClock predicts biological age across all life stages from routine clinical data, revealing distinct pediatric and adult disease risk patterns.
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Overcoming barriers to the wide adoption of single-cell large language models in biomedical research | Nature Biotechnology
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Escherichia coli with a 57-codon genetic code | Science
science.org
The near-universal genetic code uses 64 codons to encode the 20 canonical amino acids and protein synthesis. Here, we designed and generated Escherichia coli with a 4-megabase synthetic genome in...
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Democratizing protein language model training, sharing and collaboration | Nature Biotechnology
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Phages with a broad host range are common across ecosystems | Nature Microbiology
nature.com
Nature Microbiology - Proximity-ligation-based sequencing from 111 samples and 5 environments reveals that a substantial proportion of phages infect multiple species.
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