JelenaBezbradicaLab
@JelenaLab
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The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.@FabiAlexFischer
science.org
TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.
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RT @jkagan1: Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflamma….
royalsocietypublishing.org
Damage-associated molecular patterns (DAMPs) are self-derived molecules released during tissue damage that influence immune responses. Phospholipids, essential to cell membranes and lung surfactants,...
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Blazing-fast image creation – using just your voice. Try Grok Imagine.
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RT @avi_cmbi: 📢 paper - a new class of RIPK1 inhibitors. Lots of with here, with structure of it bound to RIPK1, biochemistry and more! Was….
pubs.acs.org
Necroptosis is a form of programmed cell death that, when dysregulated, is associated with cancer and inflammatory and neurodegenerative diseases. Here, starting from hits identified from a phenoty...
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RT @jkagan1: Discovery of a pH sensor that regulates inflammation. Zhou and Medzhitov provide a mechanistic tour-de-force in defining how….
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RT @Lo_Zanzi: #EpigeneticPower! Our #NewPaper @ImmunityCP shows that endogenous oxidized lipids decide whether host survives or dies during….
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RT @SamuelLaraR: Abstract submission deadline is getting close! Don't get out of this superb conference! .Inflammation 🔥.
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RT @bsicongress: Dive into cutting-edge innate immunity & inflammation science at our event on September 11!.From immune cell roles to infl….
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What a star! Huuuge congratulations @ClareBryant13 This was so deserved by years of rigorous science and selfless mentoring of others!.
What a week: I was lucky enough to get an ERC Advanced Grant, a Wellcome Trust Discovery award, and my fab colleagues at Inflammazoom nominated me for this BSI award. Thank you so much
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RT @HLRI_Cambridge: 🎉 Huge congratulations to Prof Clare Bryant on being elected a Fellow of the @acmedsci!. @ClareBryant13 .@MedCambridge….
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RT @ScienceMagazine: Scientists have discovered that the uptake of apoptotic neutrophils can switch alveolar macrophages to favor inflammat….
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What happens if inflammasome activity is not terminated in vivo? See below super cool work from @inflammasomelab @s_burgener.
Fantastic work by @inflammasomelab showing in vivo the importance of regulating caspase-1 activity in inflammatory conditions! . Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases
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RT @dave_boucher: Fantastic work by @inflammasomelab showing in vivo the importance of regulating caspase-1 activity in inflammatory condit….
biorxiv.org
Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is...
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RT @FrickelLab: 🔥 Open postdoc position in human inflammation-driven control of infection! . Join me at the University of Geneva, Switzerla….
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RT @OstuniLab: Happy to share our latest reflections @TrendsImmuno on our favourite cells: IL-1b+ macrophages 🔥🔥🔥.Molecular, spatial, temp….
cell.com
While highlighting the complexity and heterogeneity of tumor immune microenvironments, the application of single-cell analyses in human cancers has identified recurrent subsets of tumor-associated...
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RT @Lo_Zanzi: #WeekendRead! #LiveForever! @MierShawig @Asma_Farhat2 @SylviaKnapp_Lab &co show @SciImmunology that aged bone marrow, not hos….
science.org
Hematopoietic aging drives lung fibrosis and profibrotic macrophage influx, stalling their maturation via reduced Treg-derived IL-10.
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RT @Rebecca_Coll: We are recruiting a student for a really exciting PhD project on understanding how high plasma suPAR predicts poor outcom….
findaphd.com
PhD Project - Understanding how high plasma soluble urokinase plasminogen activator receptor (suPAR) predicts poor outcome in patients with ARDS. at Queen’s University Belfast, listed on FindAPhD.com
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RT @rogerjspreston: Pleased to share our latest paper in @ScienceAdvances on myeloid cell ‘trained hypercoagulability’! 🚀 Project led by @A….
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Another great story from @jkagan1 and team! On principles of self/non-self pattern recognition by LPS receptor Caspase-11.
What do Pablo Picasso and Charles Janeway have in common? Both were interested in patterns of life. Janeway was focused on pathogen associated molecular patterns (PAMPs) that are detected by our immune system. But what are these patterns he refers to?.
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Beautiful collaboration with @_kaiwenchen @domdenardo Benjamin Demarco, Felicia Chan and Michelle Yeap.
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