JelenaBezbradicaLab
@JelenaLab
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The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.@FabiAlexFischer
science.org
TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.
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Reminder: new #InflammaZoom free Webinar is today at 2 pm BST with James Murphy @pseudokinase from WEHI and Jonathan Maelfait from VIB Ghent. Register via Abcam link below. See you soon!
InflammaZoom is back on October 20. Tune in from 2:00 to 3:00 PM BST for a deep dive into innate immunity and inflammasome biology. Hear from James Murphy (WEHI, Melbourne, Australia) and Jonathan Maelfait (VIB-UGent, Ghent, Belgium). Register now: https://t.co/W0OdetaAY3
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#WeekendRead! #ToSenseOrNotToSense! #MysterySolved! Berouti, Wagner, Carell, @v_hornung &co show @CellCellPress that RNase T2 & PLDs generate #TLR7 & 8 agonistic ligands only if RNA does not contains pseudouridines explaining avoidance of self RNA sensing
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Looking forward to hosting James Murphy @pseudokinase and Jonathan Maelfait @InflamResCen as #InflammaZoom speakers on Monday October 20th. Register below via Abcam link for this free Webinar.
InflammaZoom is back on October 20. Tune in from 2:00 to 3:00 PM BST for a deep dive into innate immunity and inflammasome biology. Hear from James Murphy (WEHI, Melbourne, Australia) and Jonathan Maelfait (VIB-UGent, Ghent, Belgium). Register now: https://t.co/W0OdetaAY3
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Do not miss this! #inflammazoom is back in October 🎉 with James Murphy from WEHI and Jonathan Maelfait from VIB Ghent we are back with some really 🔥 stories!
InflammaZoom is back on October 20. Tune in from 2:00 to 3:00 PM BST for a deep dive into innate immunity and inflammasome biology. Hear from James Murphy (WEHI, Melbourne, Australia) and Jonathan Maelfait (VIB-UGent, Ghent, Belgium). Register now: https://t.co/W0OdetaAY3
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New review from our lab. Kudos to PhD student @SebGrant346534. 10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling - Journal of Biological Chemistry
jbc.org
Caspases are a family of cysteine proteases conserved across all metazoa which play critical functions that range from cell death, inflammation, and cellular differentiation. Caspases cleave a subset...
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Delighted to share that our study with @bioagelabs NLRP3 inhibitors is now online @JExpMed ! Together with @Geyer_lab @benedicte_py and @Innate_immuno we characterise BAL-0028 and BAL-0598. Excited to see the new NLRP3 biology they will reveal!
#NLRP3 is a target for anti-inflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @Rebecca_Coll et al. characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. https://t.co/w1xwgcU8wG
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Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflammation, dendritic cells, anti-tumor immunity and more. Kudos to Joon Choi for his exceptional work. @harvardmed @BostonChildrens
https://t.co/8J68zbKONa
royalsocietypublishing.org
Damage-associated molecular patterns (DAMPs) are self-derived molecules released during tissue damage that influence immune responses. Phospholipids, essential to cell membranes and lung surfactants,...
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Thanks for highlighting the preprint of our work, now online @CellCellPress
BRD4 acts as a pH sensor to tune inflammation
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📢 paper - a new class of RIPK1 inhibitors. Lots of with here, with structure of it bound to RIPK1, biochemistry and more! Was fun being part of this with Tate group and many others.
pubs.acs.org
Necroptosis is a form of programmed cell death that, when dysregulated, is associated with cancer and inflammatory and neurodegenerative diseases. Here, starting from hits identified from a phenoty...
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Discovery of a pH sensor that regulates inflammation. Zhou and Medzhitov provide a mechanistic tour-de-force in defining how BRD4 links changes in pH to inflammatory gene expression. Kudos to the authors on this exciting finding. https://t.co/DBfGC9mcPO
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#EpigeneticPower! Our #NewPaper @ImmunityCP shows that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2, blocking #IL10!
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Abstract submission deadline is getting close! Don't get out of this superb conference! Inflammation 🔥
🔥 Dive into the latest on inflammasomes, innate immunity & more at our event with @BSI_Inflam on 11–12 Sept in Manchester! Cutting-edge talks, career workshops & networking with experts. Abstract deadline: 15 July! ☑️ Submit your abstract & register: https://t.co/dZxCELfDR5
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Dive into cutting-edge innate immunity & inflammation science at our event on September 11! From immune cell roles to inflammasome signalling, discover advances shaping clinical care. Abstract deadline: 15 July Early bird registration ends: 27 August 🔗 https://t.co/dZxCELfDR5
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What a star! Huuuge congratulations @ClareBryant13 This was so deserved by years of rigorous science and selfless mentoring of others!
What a week: I was lucky enough to get an ERC Advanced Grant, a Wellcome Trust Discovery award, and my fab colleagues at Inflammazoom nominated me for this BSI award. Thank you so much
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🎉 Huge congratulations to Prof Clare Bryant on being elected a Fellow of the @acmedsci! @ClareBryant13
@MedCambridge
@Cambridge_Uni
#MedicalSciences #HLRI #Cambridge
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Scientists have discovered that the uptake of apoptotic neutrophils can switch alveolar macrophages to favor inflammation resolution over antibacterial responses in mice. Learn more in @SciImmunology: https://t.co/7HCP1dG45t
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What happens if inflammasome activity is not terminated in vivo? See below super cool work from @inflammasomelab @s_burgener
Fantastic work by @inflammasomelab showing in vivo the importance of regulating caspase-1 activity in inflammatory conditions! Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases
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Fantastic work by @inflammasomelab showing in vivo the importance of regulating caspase-1 activity in inflammatory conditions! Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases
biorxiv.org
Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is...
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🔥 Open postdoc position in human inflammation-driven control of infection! Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! Please RT (1/5)
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