Stefanie Wculek
@SWculek
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*Innate* immunologist - Dendritic cells, neutrophils, macrophages and their metabolism Junior Group Leader @IRBBarcelona
Joined September 2019
Interested in how innate immune cells adapt to survive and thrive in different environments? We are looking for a #postdoc (fully ERC-funded) to strengthen our team @IRBBarcelona! Reach out to me and apply at
recruitment.irbbarcelona.org
Created in 2005 by the Generalitat de Catalunya (Government of Catalonia) and the University of Barcelona, IRB Barcelona is a Severo Ochoa Centre of Excellence—a seal that was awarded in 2011. The ...
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#InterferonPower! Thrilled for our latest work @CellCellPress! With @dfrboehmer, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free link 👉 https://t.co/gYwGir0npB
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This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
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I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) https://t.co/Tr0nHLXRzz
nature.com
Nature - Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
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🙏 for wonderful summary @manuelansede 🙏 @FundlaCaixa @CaixaResearch for funding (1M€) 🙏 @AgEInves @CienciaGob for Severo Ochoa to initiate the project and additional funding 🙏 @ERC_Research ERC-CoG ERC-POC @CNIC_CARDIO
https://t.co/1f7c6fnC69
nature.com
Nature - Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the...
Revolution in medicine: A molecule produced by gut bacteria causes atherosclerosis, responsible for millions of deaths. The discovery, by @SanchoLab, opens the door to new treatments beyond reducing cholesterol
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🙏 @manuelansede por el fantástico artículo! 🙏 @annalaura_mstrn & Iñaki Robles-Vera @Teriyaky_852 por liderar el proyecto 🙏coautores que han hecho posible el trabajo 🙏@FundLaCaixa @CaixaResearch principal financiador 🙏 @AgEInves @CienciaGob @ERC_Research apoyo adicional
Revolución en la medicina: una molécula producida por bacterias del intestino causa la aterosclerosis, culpable de millones de muertes. El descubrimiento, del @SanchoLab, se acaba de publicar en la revista @Nature 👇
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💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. https://t.co/ZazBw50FFC
#OpenAccess at @Nature
@CNIC_CARDIO
#microbiome #CVD
nature.com
Nature - Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the...
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🧬 Major milestone for CNIC research! Three projects involving @CNIC_CARDIO @SaludISCIII have been awarded @ERC_Research Advanced Grants 2024, bringing in a total of €5.25 million ♥️MINTRAF, led by José Antonio Enríquez @GenoxphosLab del @CNIC_CARDIO y el @CIBERFES, will
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Congrats to my close friends at @CNIC_CARDIO in a brilliant and deserved success!!! Exciting projects ahead! 👏🏻👏🏻👏🏻👏🏻👏🏻
🧬 Major milestone for CNIC research! Three projects involving @CNIC_CARDIO @SaludISCIII have been awarded @ERC_Research Advanced Grants 2024, bringing in a total of €5.25 million ♥️MINTRAF, led by José Antonio Enríquez @GenoxphosLab del @CNIC_CARDIO y el @CIBERFES, will
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EVIDENCE OF SOMATIC EVOLUTION IN tRNA genes!!!! This finding could revolutionize what we know about cancer and somatic evolution in aging. Coming from the wizard of tRNA himself, Lluis Ribas, and genomeologist extraordinaire Fran Supek! https://t.co/1wUvfDVBZ0
biorxiv.org
Transfer RNA genes (tDNAs) are essential genomic elements that safeguard translational fidelity. Using the T2T version of the human genome we have mapped the position of human tDNAs and analyzed...
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🔬 1/4 Cancer research advances faster when connected globally. The Scientific Foundation (@contracancerINV ) joins @TheMarkFdn to support a major international project on colorectal cancer metastasis. 👇 #Cancer #Oncology #research
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We are looking for 1 mid-career scientist (and postdocs) willing to join us as SR-Tiget in Milan. Basic and translational immunology, gene and cell therapy, genome/protein tech, computational biology... all welcome 💚🤍❤️ check the Call, pls RT! https://t.co/1KrNePVKP2
fondazionetelethon.it
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Absolutely thrilled to share with you the final version of EPIclone, out now (open access) in @Nature. This has been an amazing collaboration with the lab of Lars Velten (@larsplus) at @CRGenomica
https://t.co/BI12Ir7fyz
nature.com
Nature - The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell...
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We’re excited to announce Hongbo Chi, PhD, as the new Chair of the St. Jude Department of Immunology. His leadership will advance our mission to find cures for catastrophic childhood diseases.
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Interdisciplinary immunologists at all levels WANTED! Faculty recruitment at Institute for Immunology, Tsinghua University, Beijing. PLEASE SPREAD THE WORD!
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Heras-Murillo et al. treated mice with tumor cell lysate-loaded syngeneic splenic selected cDC populations. https://t.co/wiubHL5MTr @CNIC_CARDIO @SanchoLab
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🚨Put a dendritic cell (DC) in your tumor #immunotherapy! cDC1-based vaccines induce strong effector & memory anti-tumor T cell response. Improved immune memory prevents tumor relapse! @CNIC_CARDIO @AgEInves @contracancerINV @FundlaCaixa @WorldwideCancer
https://t.co/cQYphYAoxX
nature.com
Nature Communications - Dendritic cells (DCs) induce infection-protective immune memory, which has yet to be exploited for cancer therapy. Here we show that type 1 DC vaccines quantitatively and...
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Led by Nacho Heras-Murillo @NachoHM3 & cosupervised by Steffi @SWculek: Thx cols @DrIgMelero @madelpozo67. Thx to support by @CNIC_CARDIO @IRBBarcelona @AgEInves @ComunidadMadrid @contracancerINV @ContraCancerEs @FundlaCaixa @WorldwideCancer
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Immunotherapy with cDC1 induces immune memory and limits tumor relapse @NatureComms @SanchoLab @SWculek @NachoHM3
https://t.co/hz242ZSiCV
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📢 Our department is looking to host a junior research group! We welcome expressions of interest from cancer researchers aiming to apply for funding through Ambizione, SNSF Starting Grants (StG), or ERC Starting Grants. Check the conditions here https://t.co/sdDvVMUFoP
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CellPhoneDB v5 is officially published! https://t.co/gsGRTokngA Very happy to have played a small role in it by developing some tools to help visualise the complex cell-cell interaction data!
nature.com
Nature Protocols - CellPhoneDB combines a curated database of receptor–ligand interactions with methods to infer cell–cell communication from single-cell expression data. This protocol...
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