Renato Ostuni
@OstuniLab
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Ultra-Professor at San Raffaele Institute, Milan. Immunity, Cancer, Genomics, Gene Therapy, and Ultra-Running. Here and "there" at https://t.co/vllLM9lUHt
Milano, Lombardia
Joined December 2017
Happy to share our latest reflections @TrendsImmuno on our favourite cells: IL-1b+ macrophages 🔥🔥🔥.Molecular, spatial, temporal, functional properties in cancer and beyond. it's all in there from the awesome @NCaronni, @lt_federica and Luca Frosio.
cell.com
While highlighting the complexity and heterogeneity of tumor immune microenvironments, the application of single-cell analyses in human cancers has identified recurrent subsets of tumor-associated...
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This is a milestone resource! Everything you need to know about interferons by @Lo_Zanzi &team💣💣💣.
#InterferonPower! Thrilled for our latest work @CellCellPress! With @dfrboehmer, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free link 👉
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RT @lai9uan: Hot off the press in@ImmunityCP! 🔥 Proud to share our new perspective — a collaborative effort with fantastic colleagues — pro….
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Out in @ScienceTM! The Naldini lab delivers another masterclass of stem/immune cell gene engineering to deliver cytokines in the TME and boost CAR-T cell activity in glioblastoma. Kudos to @f_rossari @giorgiaalvisi and Nadia Coltella for this important study🔥.
🧵1/.🚨 Just out in Science Translational Medicine @ScienceTM our latest work @NaldiniLab:.We show how tumor-targeted cytokines can rescue CAR-T function and recruit endogenous T cells to fight glioblastoma, the toughest brain cancer. 🔗👇 Here's a thread:.
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RT @f_rossari: 🧵1/.🚨 Just out in Science Translational Medicine @ScienceTM our latest work @NaldiniLab:.We show how tumor-targeted cytokine….
science.org
Tumor-targeted cytokine delivery by TAMs establishes a private cross-talk that rescues CAR T cell function and engages host T cells to treat GBM.
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Neutrophil aficionados, this is THE meeting! Don't miss it🎯.
The wait is over, it’s back! 🧪 .Granulocyte Meeting 2025 | 15–18 Sept | Shanghai. Big science. Big names. Big City. Don’t miss it. 🔗 #Gmeeting2025 #Granulocytes #ThePowerOfMany
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Check this out! Great stuff, as usual from the @iannaconelab.
1/ 🚨 Hot off the press in @NatImmunol: CD4⁺ T cells can license Kupffer cells to rescue dysfunctional CD8⁺ T cells in the liver. Hepatitis B virus (HBV) infection is just the proving ground—this is a paradigm shift in tissue immunity. 🧵(1/11).2/
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Great piece @MiriamMerad @WSJ "separate beneficial inflammation, the one that protects us from microbes and from tumors, from the pathogenic inflammation that is enhancing cancer progression, promoting atherosclerosis, promoting damage in the older brain".
wsj.com
Inflammation fuels the high rate of cancer in people over 50, researchers find, leading them to test anti-inflammatories like allergy drugs to fight it.
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Not just mitosis - the centromere as a site of immune activation 🔥🔥🔥. Viral proteins alter centromere organization and local amplification of DNA -> this is recognized by nuclear cGAS-STING. beautiful stuff by Nicolas Manel lab in @CellPressNews .
cell.com
Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune surveillance mechanism in the...
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The field of exercise-immuno-oncology is taking off. out now in @NEJM "A 3-year structured exercise program initiated soon after adjuvant chemotherapy for colon cancer resulted in significantly longer disease-free survival".
nejm.org
Preclinical and observational studies suggest that exercise may improve cancer outcomes. However, definitive level 1 evidence is lacking. In this phase 3, randomized trial conducted at 55 centers, ...
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We are looking for 1 mid-career scientist (and postdocs) willing to join us as SR-Tiget in Milan. Basic and translational immunology, gene and cell therapy, genome/protein tech, computational biology. all welcome 💚🤍❤️ .check the Call, pls RT!.
fondazionetelethon.it
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RT @LiabeufDylan: Thank you @OstuniLab, Filippo and the Italian Outdoor Fest. for organising such a cool and informative event! . Last kms….
berlin-barcelona.com
The Berlin-Barcelona Health Awareness Challenge encompasses a series of compelling interviews with individuals making significant contributions across sports, science, and advocacy.
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📌Join us at the Italian Outdoor Festival this Sunday!. Will speak with @LiabeufDylan ( and ultrarunning legend Filippo Canetta about #immunology #running #exercise #Wellness #scicomm . @MyUniSR @SanRaffaeleMI @Fondaz_Telethon .
berlin-barcelona.com
The Berlin-Barcelona Health Awareness Challenge encompasses a series of compelling interviews with individuals making significant contributions across sports, science, and advocacy.
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RT @ferrari_sam93: 🚨 What if a single DNA typo could inflame the body and outcompete healthy blood cells?. 🧬 This happens in #VEXAS syndrom….
nature.com
Nature Medicine - Analyses of single-cell transcriptomic data from patients with VEXAS syndrome combined with xenotransplantation experiments in a mouse model of the disease provide insights on the...
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RT @LabWaggoner: Review @TrendsImmuno @NCaronni @OstuniLab.IL-1β+ macrophages and the control of pathogenic inflammation in cancer. https://….
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and here's the Sharelink with full access:
Happy to share our latest reflections @TrendsImmuno on our favourite cells: IL-1b+ macrophages 🔥🔥🔥.Molecular, spatial, temporal, functional properties in cancer and beyond. it's all in there from the awesome @NCaronni, @lt_federica and Luca Frosio.
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RT @MatthewD_Park: A must-read review on the recent developments in the field that refine our understanding of IL-1 in cancer development a….
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RT @TrendsImmuno: IL-1β+ macrophages and the control of pathogenic inflammation in cancer #immunology
https://t.co/….
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RT @MiriamMerad: Thank you Renato for a clear and timely review highlighting how IL-1β⁺ macrophages contribute to disease both locally by f….
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RT @Lo_Zanzi: #MustRead. For #TumorImminologyLovers & more, check this fantastic review @OstuniLab @NCaronni &co @TrendsImmuno all about #I….
cell.com
While highlighting the complexity and heterogeneity of tumor immune microenvironments, the application of single-cell analyses in human cancers has identified recurrent subsets of tumor-associated...
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