Sergi Regot
@RegotLab
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Developing biosensors to study signaling dynamics and cell fate during collective cell behavior
Baltimore, MD
Joined April 2019
The @RegotLab is searching for talented #postdocs! If you or someone you know is interested in #SignalingDynamics please apply and share #postdocjobs #Hiring #Biology #PhD #AcademicTwitter
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I’m happy to share that I’ve been selected as a 2025 HHMI Gilliam Fellow. This fellowship will support my PhD research at Johns Hopkins, where I study whole-genome doubling in tumor evolution. https://t.co/iDQRJrsXtZ
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Connor's paper is out in Science! Thanks to all the present and former lab members for making this possible. If you are interested in the mechanisms behind stress induced endocycling or the role of CDK4/6 in maintaining G2 arrest, check it out: https://t.co/jNRSQhfGCh
science.org
Cell cycle events are coordinated by cyclin-dependent kinases (CDKs) to ensure robust cell division. CDK4/6 and CDK2 regulate the growth 1 (G1) to synthesis (S) phase transition of the cell cycle by...
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Excited to share my latest research work just published online today in @NatureCellBio! We find oncogenic Kras mutation induces abnormal tissue architecture through converting pulsatile into sustained ERK signal activation. @nyscf @YaleGenetics
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@NatureCellBio @nyscf @YaleGenetics I am very grateful to all the co-authors, especially my incredible mentor Valentina Greco @valentatormenta, our wonderful collaborators Sergi Regot @RegotLab, Hironobu Fujiwara @HiroFujiwara and H. Amalia Pasolli @APasolli.
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Cell signaling investigators, submit your cutting-edge research by May 12! @albecklab, @Mia__Sung, @steve_cappell, and @schmittwitt_ are looking forward to featuring you at #DECSRC for a short talk or poster session. View the details and save your space: https://t.co/fD5pXmXT5f
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Congrats to our amazing graduate student Connor Mckenney on his recent poster presentation at the Conceptual power of single cell biology conference!!
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Why are senescent cells irreversibly arrested in the cell cycle? Today in @CellReports we report in a study led by talented postdoc @Afifi_MM that the transcription factor MYC is constantly degraded, keeping the cells locked in a non-proliferative state.
cell.com
Afifi et al. use time-lapse imaging, high-throughput single-cell analyses, and quantitative measurements to investigate the irreversibility of cellular senescence. Senescent cells enter and maintain...
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Congrats to our great graduate student @AdlerGuerrero on presenting his poster/talk on how sustained ERK signaling leads to whole genome doubling through mitotic bypass at the Gordon Research Conference for Cell Growth and Proliferation.
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Congrats to our great graduate student Connor Mckenney on winning the @JohnsHopkinsMBG Journal Club Award this year!! 📖🧬
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A book in genetics for kids. What’s wrong with this picture?
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Really cool new report in @CellSystemsCP by @RegotLab and @amyfpeterson from @JohnsHopkinsMBG. https://t.co/RtYHVuFFXZ Since the cool thing these days with #peerreview is to experiment, my first-round review of the paper is also published and linked in the 🧵below
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Excited to share our preprint about "Bursting Translation on Single mRNAs in Live Cells" https://t.co/9Vf0Y5SAJW by Nathan Livingston @nliving93 and Jiwoong Kwon, in collaboration with @JianLiu_Lab, @GreenLabJHMI and @taekjip
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Are all phase-separated compartments functional, or are some “accidental condensates”? Check out our new preprint with @PAskjaer to find out more: https://t.co/t8mjKMh0fX
biorxiv.org
Nucleoporins (Nups) assemble nuclear pores that form the permeability barrier that separates nucleoplasm from cytoplasm. Nups have also been observed in cytoplasmic foci proposed to function as pore...
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Excited to share the preprint of my latest work. Wonder how oncogenic Kras disrupts tissue architecture? We find it does so through converting pulsatile into sustained ERK activation! Thank my mentor @valentatormenta, collaborator @RegotLab and other authors!
Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation https://t.co/Ikt17eogYV
#bioRxiv
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😄Super happy to share our paper to the public! Thanks for everyone supporting me and my mice willing to tell me the 'secret' of hair follicle! This work answers the importance of the beautiful niche architecture (See movie) to stem cells and organ function! Welcome feedbacks.
Reorganizing Niche Architecture Still Preserves Organ Function in the Hair Follicle https://t.co/CEbxQ4qSth
#bioRxiv
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The @RegotLab is searching for talented #postdocs! If you or someone you know is interested in #SignalingDynamics please apply and share #postdocjobs #Hiring #Biology #PhD #AcademicTwitter
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