Bin Wu Lab
@binwu1
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Associate Professor of Biophysics @HopkinsMedicine
Baltimore, MD
Joined May 2010
RT @Weihan_Li_: My lab at Brown University is hiring a postdoctoral fellow! We develop single-molecule imaging technologies to dissect the….
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RT @JohnsHopkins: The latest designs of a new Life Sciences Building on the Johns Hopkins East Baltimore medical campus were recently share….
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RT @thewlaprize: Meet Jeremy Nathans, the 2024 World Laureates Association Prize (#WLAPrize) laureate in Life Science or Medicine. As a p….
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RT @CWolberger: We are hiring! Position open for a new assistant professor in the Department of Biophysics & Biophysical Chemistry in @Hop….
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RT @LCochella: Our department @JohnsHopkinsMBG ( is hiring!.Join us to start your independent lab in a collegial a….
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RT @deniswirtz: Bloomberg Philanthropies gives $1B to Johns Hopkins University. This gift makes the School of Medicine tuition-free for st….
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RT @CellReports: DNA break induces rapid transcription repression mediated by proteasome-dependent RNAPII removal
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We used very-fast CRISP to induce single DSB and observed transcription repression in minutes. The repression propagates along chromosome for hundreds of kb. Interestingly, the rapid repression doesn't depend on H2AK119 ubiquitination, but relies on proteasome to remove RNAPolII.
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Excited to share that our paper on transcription repression after DNA double-strand break is online. Great collaboration with @taekjip and @yliu_UofU, spearheaded by Shuaixin He @BiophysicsJHMed @BCMB_JHMI
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@Evident_LS @CWolberger @LCochella @jiexiao_lab @jmcoller @InoueLabJHMI Special thanks to the lab manager Darcey McDowell and the camp aids Kodi Harris, Fujr Osman and Hannah Wu.
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The students learned microscopes, DNA, crystal, worms, visual illusion, coral, cells, slimes. Thank you, @Evident_LS, Jeremy Nathans, @CWolberger, Bethany Gray, @LCochella , Josh Modell, Bear Huang, @jiexiao_lab , Caren Meyers, @jmcoller, @InoueLabJHMI and your amazing labs.
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We had a great week of Fun with Science Summer Camp. 16 5th and 6th graders from Baltimore area attended this annual event supported by @BiophysicsJHMed and Career for Science and Medicine. 11 Hopkins lab and @Evident_LS organized fun and engaging activities.
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RT @CWolberger: Baltimore middle schoolers learning about crystal lattices in Fun With Science Camp, an annual program run by @binwu1 in @B….
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RT @NatureComms: A Rapid Inducible RNA Decay system to study mRNA dynamics in P-bodies @binwu1 @LABlake93 @JohnsHopkins #RNA #singlemolecul….
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RT @LABlake93: Beyond excited for my PhD work to be out in press! This is my first first-author primary research article. Thankful for the….
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Interestingly, when imagining with high laser power or treating cells with oxidative stress, mRNAs are still recruited to PBody, but don't decay. This suggests that the function of PBody may be context dependent.
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We observed mRNAs induced to decay were recruited to PBody and rapidly disappear, presumably decayed there. With modeling, we showed that the decay is faster inside PBody. Alternative models requiring no decay or decaying with the same speed did not fit the data.
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We used a chemical induced dimerizer to recruit a decay factor onto RNA that causes rapid Inducible decay of RNA, which we called RIDR.
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Very excited to share that our paper about Inducible RNA decay and P-Body is published on @natcomms. This work was spearheaded by @LABlake93 @BiophysicsJHMed in collaboration with @InoueLabJHMI and @yliu_UofU.
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