Dave Root
@NeuronRoot
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Neuroscientist at CU Boulder 🦬
Boulder, CO
Joined July 2011
Going to mostly move to the other place but we're looking to hire an electrophysiologist, please get in touch if interested
jobs.colorado.edu
CU Boulder Jobs
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The Elsaafien laboratory is actively #hiring! We are looking to recruit a postdoctoral fellow with a background in autonomic neuroscience and cardiovascular disease: https://t.co/jpbXvvcVZ4 Send inquiries to: khalid.elsaafien@lsuhs.edu @APSPhysiology @American_heart
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Please chk out the lab's newest paper, a labor of love it was. From @aluskin & @dilithium21, w/ @madisonmartin @Braininajarr @mouse_braind @GoldenNeuron @gstuber & others. We report a new road map for the LC-NE & peri-LC systems. Thx @NIMHgov @NIDAnews
nature.com
Nature - A set of neurons in the peri-locus coeruleus region controls arousal and avoidance states, providing an understanding of the neurobiological basis of arousal and exploratory behaviours.
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📢 New paper : Amygdala hyperactivity is a hallmark of anxiety, but how it happens remains a mystery. Using a mouse model of social stress, we uncovered key mechanisms behind this shift. Amazing collaborators in Bordeaux, Baltimore, and Buenos Aires 🧠⚡ https://t.co/JT1Fzy6oII
biologicalpsychiatryjournal.com
Brain defensive mechanisms evolved to maintain low levels of state anxiety. However, risk factors such as stress exposure shift activity within defensive circuits, resulting in increased anxiety. The...
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Excited to share our single-cell study on aging mouse brain published in Nature today! We found an aging hotspot in specific hypothalamic cell types involved in energy homeostasis, which show both decreased neuronal function and increased immune responses.
nature.com
Nature - A comprehensive single-cell RNA sequencing study delineates cell-type-specific transcriptomic changes in the brain associated with normal ageing that will inform the investigation into...
New brain aging study is out today in | @Nature The largest single-cell RNA seq dataset of mouse brain aging reveals incredible insights and could pave the way for future therapies to slow or manage the impacts of the aging process. 🧵 #studyBRAIN
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Excited to share my profile on @storiesofwin after a wonderful conversation with @DrNancyPadilla about my path in neuroscience & what’s ahead for our lab at @MPFNeuro! Feeling honored to be featured alongside so many inspiring women in the field 🧠✨ https://t.co/fG1eRpf8ke
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13 years ago, I was dying from OUD. The 12 steps saved my life, without any need for a belief in god. I learned a way of living that provided freedom from my addiction and the prison of emotional entanglement. If you’re struggling, my DMs are always open. 🙏
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It is more important than ever to spend time talking to people about science. Communicate its value, and its objectivity. Talk to your neighbors, your bartenders, your barbers, your congressmen. Talk kindly to people whose political views differ from yours. Protect science.
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🚨 New Research Excited to share my PhD work now published in @Cell_Metabolism In this study we explore the role of the gut microbiota in regulating the complex interaction between stress and circadian rhythm link: https://t.co/0HLMptKb7t Follow the 🧵 for the key findings
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"Cinematic start to science" :). Had a lot of fun with this interview!
What if traumatic memories could be erased? In a Q&A, Beckman Director Steve Maren (@StephenMaren) reflects on his cinematic start to science, explains his fascination with the amygdala and explores on emotional memories both personal and scientific. 💬 https://t.co/MIAVNkJ75r
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My PhD work is finally out in @NeuroCellPress! "Heightened lateral habenula activity during stress produces brainwide and behavioral substrates of susceptibility" w/ amazing team @IlanaWitten @ZimmermanNeuro @lindsaywillmore @Neurrriot @alexpan_neuro
cell.com
Zhukovskaya et al. show that during social defeat, stress-susceptible mice have higher initial activity in LHb. Closed-loop LHb activation during defeat produces lasting behavioral and neural...
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New preprint w/ @lab_plotkin about cholinergic interneurons causing local serotonin release in striatum and how this is related to obsessive-compulsive disorder https://t.co/h1W6zaC61J For the story, read on 1/9
biorxiv.org
Striatal cholinergic interneurons (CINs) activate nicotinic acetylcholine receptors (nAChRs) on dopamine axons to extend the range of dopamine release. Here we show that synchronous activation of...
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Does Drug Intake Despite Adverse Consequences Really Measure Compulsivity? There’s a big debate in addiction research: is drug use despite adverse consequences (like punishment) a standalone measure of compulsive behavior, or just part of a larger addiction profile? This new
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God grant me the confidence of the dude that tried to mansplain "The Handmaids Tale" to Margaret Atwood.
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Synchronous activation of striatal cholinergic interneurons induces local serotonin release https://t.co/sqEfQDwzbE
#biorxiv_neursci
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Pls Chk out the lab's recent work from Eric Zhang (not on X), now in press & pre-printed. "Dentate Gyrus Norepinephrine Ramping Facilitates Aversive Contextual Processing". Thanks to @yulonglilab for the early collab using GRAB-NE2m. https://t.co/GCVbnoXXLl
biorxiv.org
Dysregulation in aversive contextual processing is believed to affect several forms of psychopathology, including post-traumatic stress disorder (PTSD). The dentate gyrus (DG) is an important brain...
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Last chance! The deadline to submit an application for the ACNP Early-Stage Investigator Assistance Program is TODAY, October 31st, at 5:00 pm Central. As a reminder, you must already have an in-person invitation or be registered to attend the meeting in person to apply. For more
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Risk avoidance behaviors and relief by alcohol are driven by imbalance of brain dopamine receptors in mice
communities.springernature.com
Alcohol use disorder is frequently comorbid with anxiety disorders. Our recent study, published in Nature Communications, applies mouse models to explore the relationship between alcohol use and...
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