mbruchas
@mbruchas
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Neuroscientist, GPCRs, Food, Music, Wine, Beer, Travel, Books, Outdoors, BBQ, Video/Board Games, Hockey, Fußball. (views mine / not lab’s or University’s)
38.643373,-90.24488
Joined December 2008
Pls check out the lab's newest preprint. Dopamine release and dynamics from LC-Noradrenergic Neurons. https://t.co/73DWqb9Pgq
biorxiv.org
Arousal is essential for survival, and maladaptive arousal processing leads to an inability to focus, anxiety-like behavior, and dysregulated affective states. Norepinephrine (NE) is known to...
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Today, I'm excited to share my PhD work in @mbruchas's lab was posted to bioRxiv! In this work, we carefully examine under which conditions LC-norepinephrine neurons release dopamine, specifically in response to rewarding and aversive stimuli. Check it!
biorxiv.org
Arousal is essential for survival, and maladaptive arousal processing leads to an inability to focus, anxiety-like behavior, and dysregulated affective states. Norepinephrine (NE) is known to...
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So grateful to have @brittonrae5 on our team contributing her social media prowess to promote the DPN journal 😁
A HUGE thank you👏 to @brittonrae5, our Editorial Intern, for spearheading this effort to expand our social media presence!
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The last papers I worked on at Nature still coming out. This one from @michael_krashes 's group about parental behaviors is really elegant. One of the best ones I worked on at Nature https://t.co/8yH9NaTeJ9
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🥰 Self-supervised, label-free 3D cell imaging is here https://t.co/qjdAvbPLdX
#epfl #elife Congrats to @AChRD4 on this very cool first, first author publication 🏆! This started when he was a bachelor's student (and he's now completing his masters!). And many thanks to my
actu.epfl.ch
EPFL researchers introduce CellSeg3D, a self-supervised tool for 3D cell segmentation in fluorescence microscopy, eliminating the need for manual labeling and enhancing accessibility for various...
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Our new paper in collaboration with Bill Carlezon and @ErikMusiek on the effects of pain on sleep architecture is now out at @npp_journal . Work done by the amazing @DominikaJBurek and @khairunisa_ibk
https://t.co/SayKICzBYp
nature.com
Neuropsychopharmacology - Inflammatory pain in mice induces light cycle-dependent effects on sleep architecture
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Thrilled to announce that our paper is now finally out! 🎉We combine scRNAseq, 2p imaging, ephys, and behavior to understand the role of lateral septal Nts neurons in opioid withdrawal. Curious about the septum and addiction? Give it a read👇 https://t.co/3ZLg0EEStJ
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I’m excited to share a new paper from the lab. The study led by Xiaowei Gu reveals how the mPFC encodes complex emotional memories, using an internal model to infer emotional associations and memories via projections to the amygdala https://t.co/zkhSD98GlD
https://t.co/dgNBPSNj5l
nature.com
Nature - Neurons in the rodent dorsomedial prefrontal cortex encode a flexible internal model of emotion by linking directly experienced and inferred associations with aversive experiences.
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Please chk out the lab's newest paper, a labor of love it was. From @aluskin & @dilithium21, w/ @madisonmartin @Braininajarr @mouse_braind @GoldenNeuron @gstuber & others. We report a new road map for the LC-NE & peri-LC systems. Thx @NIMHgov @NIDAnews
nature.com
Nature - A set of neurons in the peri-locus coeruleus region controls arousal and avoidance states, providing an understanding of the neurobiological basis of arousal and exploratory behaviours.
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Excited to share lab's new paper co-led w/ @ProfJohnARogers where we merge localized pharmacology with photometric recordings in vivo " in @NeuroCellPress . Thx authors @PiantadosiSean @MingzhengWu @MingzhengWu @NeuroLuxInc @AvilaROAD @NUro_science @NIDAnews @NIMHgov @NIH BRAIN
Excited to share work from @mbruchas & @ProfJohnARogers labs led by myself, @MinKyuLeePhD and @MingzhengWu with critical help from @NeuroLuxInc, @AvilaROAD, @NUro_science, and Dr. Yonggang Huang. Work proudly supported by @NIDAnews, @NIMHgov, and the @NIH BRAIN Initiative.
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I’m excited to share the most recent study from the @mbruchas lab, which represents the culmination of my postdoctoral work, and serves as the platform for my future research programs investigating the in vivo role of the endocannabinoid signaling system! https://t.co/IzShlPjF68
biorxiv.org
Neuromodulatory signaling is poised to serve as a neural mechanism for gain control, acting as a crucial tuning factor to influence neuronal activity by dynamically shaping excitatory and inhibitory...
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Pls chk out the Bruchas lab's new preprint "Endocannabinoids facilitate transitory reward engagement through retrograde gain-control". Congrats @DavidJMarcus2 @cloverpharm @StellaLab11 @Graphtablet & many other colleagues.
I’m excited to share the most recent study from the @mbruchas lab, which represents the culmination of my postdoctoral work, and serves as the platform for my future research programs investigating the in vivo role of the endocannabinoid signaling system! https://t.co/IzShlPjF68
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The final paper of my PhD is up on BioRxiv!! I’m so excited to see this out in the world! We conducted multiple genetic manipulations to uncover which NAc cell pop is necessary for opioid receptor modulation of social behavior. *spoiler* it’s not the population you expect!
Mu opioid receptor expression by nucleus accumbens inhibitory interneurons promotes affiliative social behavior https://t.co/2QDYKQ1APn
#biorxiv_neursci
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@UW_NBIO is hiring two tenure-track assistant professors. Apply here: https://t.co/3C6i3RVyIT Come join us at @UW!
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Pls Chk out the lab's recent work from Eric Zhang (not on X), now in press & pre-printed. "Dentate Gyrus Norepinephrine Ramping Facilitates Aversive Contextual Processing". Thanks to @yulonglilab for the early collab using GRAB-NE2m. https://t.co/GCVbnoXXLl
biorxiv.org
Dysregulation in aversive contextual processing is believed to affect several forms of psychopathology, including post-traumatic stress disorder (PTSD). The dentate gyrus (DG) is an important brain...
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Strong endorse, super exciting research program. Chk it out!
Our lab is hiring a postdoc or staff scientist to join our NIH Pioneer Award-funded project on artificial hibernation. We welcome candidates with diverse backgrounds in neuroscience, metabolism, ultrasound, and related fields. #ResearchJobs #ArtificialHibernation #NIHPioneerAward
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Great Ph.D Pharmacology program, lots of exciting research, mentoring and cutting edge training. Application details below!
Please RT! We are officially accepting applications to the @UW Pharmacology PhD program! Are you excited about doing a PhD in a cutting-edge, multidisciplinary community that spans all levels of pharmacology? Come join us! Deadline is Dec. 1. https://t.co/kaUVZ5d1hY
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Come explore emerging research in brain-body communication @KeystoneSymp Interoception: Neural Sensing and Control of Organ Function, this April in Seattle! https://t.co/l6KIgl5sSd
#KSInteroception25
keystonesymposia.org
Join us at the Keystone Symposia on Interoception: Neural Sensing and Control of Organ Function, April 2025, in Seattle, with field leaders!
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Beyond thrilled to present our O-MAP—now *published* @naturemethods (!!!) O-MAP is a powerful new method for biochemically "dissecting" the subcellular microenvironment around an RNA of interest, using off-the-shelf parts and standard manipulations. 🧵 https://t.co/gBGsQ6dBs9
nature.com
Nature Methods - Oligonucleotide-mediated proximity-interactome MAPping (O-MAP) enables precise multiomic characterization of biomolecular interaction networks at target RNAs. Distinct O-MAP...
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Super exciting from the @ShechnerLab in @UWPharmacology. Check it out! Congrats all!
Beyond thrilled to present our O-MAP—now *published* @naturemethods (!!!) O-MAP is a powerful new method for biochemically "dissecting" the subcellular microenvironment around an RNA of interest, using off-the-shelf parts and standard manipulations. 🧵 https://t.co/gBGsQ6dBs9
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