Lin Tian, PhD
@LinTianPhD
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Scientific Director @MPFNeuro | Developing optical & molecular tools for 🧠 research & 💊 discovery | Baseball mom, swim mom & dog mom
Jupiter, FL
Joined December 2017
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Pinned Tweet
New paper out in
@NatureNeuro
!
Collaborating with several labs, we developed genetically encoded biosensors to track opioid pharmacology in the brain & provide powerful new tools for dissecting complex circuit-specific dynamics 🔧🧠
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Very fortunate to have worked with excellent graduate students to develop psychLight, a 5-HT2A receptor based sensor, to detect serotonin and predict hallucinogenic potentials. (1 of 2)
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Pleased to highlight 3 exciting new papers in our recently released News & Views article 💡 🧠
Phenomenal work by
@ChenLabNeuro
,
@MichaelLinLab
&
@AdamEzraCohen
!
Read the full article here ⬇️
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Excited to share, dLight1, our genetically encoded dopamine sensor with the world today!! Congrats
@tpatriarchi
!
@NIH
@BRAINinitiative
@NIDAnews
#dopamine
#fluoresence
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Here we used machine learning to guide directed evolution to design and radically change the ligand binding pocket for sensor engineering. Excellent team work with
@LoogerL
,
@VivianGradinaru
,
@superkash
,
@vyy_sf
! (1 of 2)
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A big thank you to
@naturemethods
and Vivien Marx for this opportunity to share my story and passion for what I do. I am very grateful for my mentors, collaborators, trainees and of course my family for making this all possible.
“Collaboration will lead you really to another layer of the science,” says
@LinTianLab
@ucdavis
. She talks about her new dopamine sensor, the link between neurochemistry and behavior, women in science, her time at
@HHMIJanelia
. With comments from
@LoogerL
.
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All materials are available at
@Addgene
and the
@neurophotonics
viral core!
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Thrilled to be visiting
@CSHL
as a lecturer for the course on Imaging Structure & Function in the Nervous System! 🔬🧠
It has been wonderful to catch up with colleagues and friends, including the brilliant
@denisejcai
.
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We’re thrilled to launch the brand-new Tian Lab website! 🧠🎉
Delighted to share this new home for our work as we settle into our new lab
@MPFNeuro
.
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The Tian lab is hiring!! We have NIH funded post doc positions available. If using and engineering new sensors excites you —get in touch!
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Great collaborative effort between all the labs —Thank you von Zastrow lab,
@berke_lab
@Wiltgenlab
and all the co-authors! This work further emphasizes that biology guides tool development. We are grateful for all the biologists who are willing to try our prototype sensors (1/2)
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The Tian lab is heading to
#SfN23
🧠🔬
Looking forward to poster presentations by Kwun Nok Mimi Man,
@jin_jinyihanmg
and
@kiranlongiyer
& talks by Nikki Tjahjono and
@JulieChouinard7
.
#SfN2023
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The 2022-2023 school year is off to an amazing start!
To celebrate, I’d like to spend a moment highlighting recent Tian Laboratory member achievements 🏆
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6m, 6s, 6f all available on addgene
congrats
@JoeyBroussard6
!
Ever wanted to try GCaMP imaging in axons, but worried about dim signal? Check out our work on development of an axon-targeted GCaMP: Congrats to collaborators from labs of
@leo_petreanu
and Na Ji!
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Great news! We are running a systems neuroscience search for two tenure track assistant professors. Application deadline Nov 1.
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After years of hard work and uphill battles dealing with hiPSCs, this is out! Our lab is not only interested in sensor engineering - we like astrocytes too! Congrats to graduate student
@_graceor
!!
#astrocytes
#iPSCs
#Downsyndrome
@NINDSnews
@NIH
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Double congratulations to the Tian lab’s graduate UC Davis Allen G. Marr Prize awardee for superior dissertation work, Dr.
@JasonCDong1
! We’re so happy to celebrate your achievements.
Read his pre-print on kLight to learn more about his recent work 🔗
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I’m hopeful for the therapeutic potential of
#psychedlicmedicine
& am proud of the innovative research happening at Davis.
Great summary – including our psychLight biosensor for 5-HT2A receptor activity by
@JasonCDong1
et al.
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Congrats to our stellar graduate student
@gracemizuno
for being awarded the Dean’s Mentorship award and the Barbara Horwitz and John Horowitz Molecular, Cellular and Integrative Physiology Award!!🍾 🎉
@UCDavisResearch
@UCDavisGrad
@ucdavis
@MCIPUCD
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A sweet and bitter moment as we celebrate
@gracemizuno
’s success and achievement in grad school at her Exit Seminar. A bright future ahead with unlimited surprises and opportunities as she leads
@SevenBiosci
! We will miss you so much but we are excited for your next venture!
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Our graduate student Grace Or has been selected for the Keller Fellowship: a UC Davis program for innovators and aspiring/early-stage entrepreneurs to expand their networks and move ideas out of the lab and into the world. Congrats
@_graceor
!!
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Our lab had such a fun time at
@UCDavisCNS
#NeuroFest
last Saturday! Great job
@JRoshgadol
, Nikki Tjahjono,
@JulieChouinard7
, Yihan Jin & Erin Scott presenting our ‘Shining Light on the Brain’ 🧠🔦 poster & demo at our biggest Neuroscience outreach event of the year!
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Gearing up for our minisymposium at
#SfN23
tomorrow!
Excited to share some new findings from our biosensors during this session!
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A special shoutout to the Tian lab undergrads 🌟
To celebrate their hard work and achievements, last week we hosted an Undergraduate Appreciation lunch.
Feeling grateful to have such an amazing group of students!
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Looking forward to learning a lot at the 2023 GPCR Workshop in Kona, Hawaii 🌴 Yihan Jin will be presenting our work on
#GPCR
-based sensors.
Thanks to the ConfometRx Research Foundation & the
@UCDavisCNS
Barbara Chapman Neuroscience award for supporting Yihan!
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Useful information to design and apply genetically encoded indicators. A wonderful collaboration with
@ryanjhcho
@VivianGradinaru
@JoeyBroussard6
and no Twitter Aaron Marley, Mark Von Zastrow
@UCSFMedicine
Katharina Merten Axel Nimmerjahn
@salkinstitute
and John William
@ngpohsu
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Enjoying the talks and spending time with friends & colleagues at
@MPFNeuro
#Sunposium23
!
So glad to hear about all the great science
@LinTianPhD
is getting up to! Say hi if you’re at
@MPFNeuro
#sunposium23
🌴🍊
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Great work
@mohebial
and
@berke_lab
!
From a technical standpoint this study demonstrates that all three techniques: FSCV, microdialysis (Kennedy’s lab) and optical imaging are indeed complimentary. Fun collaboration!
Our flagship new dopamine paper is out:
NAc dopamine release is not a passive readout of VTA dopamine cell firing,
but appears instead to be locally sculpted to create motivational signals.
Tremendous work by Ali, Jeff and our wonderful collaborators!
Josh
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Thank you to
@AmyPalmerZinc
& Serge Campeau for hosting me in Boulder this week! I appreciate the warm welcome from faculty & trainees in the
@CUBIOCHEM1
,
@CUBoulderBN
& Biophysics training programs.
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Thank you to everyone who has supported my journey thus far. I am deeply grateful for your support, guidance & friendship over the past 10 years.
I am looking forward to this next chapter and establishing the Tian Lab in Florida!
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Congrats to Nikki’s team for winning this year’s Tian Lab Halloween decoration contest 🎃🦇
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Delighted to be co-chairing the
@OpticaWorldwide
Biophotonics Congress in the Life Sciences! Join us to share the latest advances in
#optics
and
#photonics
🔦🌈💡
Please submit your paper by December 21st:
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Congrats to the
@KappaCon2023
ToniShippenberg awardees for their outstanding science and oral presentations
PhDs students:
@MarwaMikati
&
@JasonCDong1
PostDocs :
@Valen_Tina_MD
&
@outRaajeous
And thank you
@NeuroTejeda
for another outstanding KappaCon!!
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Neuroscience graduate student Erin Scott received an
@NIH
Ruth L. Kirschstein National Research Service Award (NRSA) T32 training grant.
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The city of Davis issued “shelter in place” today. Kind of expected. Lab is shutting down. Maybe we will discover something new in this difficult and challenging times.
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Great symposium today at the
#BRAINInitiative
investigators meeting. Special thanks to the speakers:
@ERSchreiter
@berke_lab
@Ryohei_Neuro
, Na Ji, Tianyi Mao and Loren Looger with support from Doug Kim and Ned Talley!
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Finally, The Tian Laboratory welcomed incoming Master’s degree students Yiwei Hua & Sherin Lajevardi who both joined the Molecular, Cellular and Integrative Physiology 👏🏼
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Congrats Dr. Broussard
@JoeyBroussard6
! Our first graduate student in the lab gave an excellent exit seminar today. Now, off to do great things in
@SamWangPhD
’s lab!
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Exciting collaborative effort with
@DEOlsonLab
, Dr. William Wetsel and Dr. Won Chan Oh! Congrats to
@JasonCDong1
,
@Calvin47068916
, and
@LeeDunl49298493
for this great work. Look forward to seeing
@SevenBiosci
use the sensor to push the boundaries of drug discovery. (2 of 2)
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Graduate student Yihan Jin received the 2022 Barbara Chapman Neuroscience Award.
This award will allow Yihan to explore off-site educational & training opportunities.
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Biomedical engineering graduate student Nikki Tjahjono was awarded an
@NIH
F31 fellowship, providing independent funding for her dissertation work.
Special thanks to the
@UCDavis
Predoctoral Training Program in Pharmacological Sciences &
@UCDavisBMEGG
.
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Also, great collaboration with
@rhodamine110
,
@DEOlsonLab
,
@jenn_prescher
,
@lesterha
, Veronica and many others. Great work from
@ElizabethKUnger
,
@AltermattMi
, Jacob, Aya, Ruqiang with contribution from
@JasonCDong1
,
@olivia_hon
,
@gracemizuno
and all others. (2 of 2)
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and troubleshoot with us! It’s a good red sensor to start but there is definitely room for improvement and we look to continue to engineer better sensors driven by the biological gaps. Big thanks to our funding agencies
@NIH
BRAIN Initiative (2/2)
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Huge congrats to our postdoc Tommaso Patriarchi on his publication acceptance titled "Nanodelivery of a functional membrane receptor to manipulate cellular phenotype" in
@SciReports
!!!
#nanodelivery
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It was a pleasure to chat with
@MerylDL
about psychedelics, drug discovery & psychLight for this story!
There's so much exciting
#mentalhealth
research on
#psychedelics
it's not surprising companies are jumping in to explore how to make them better as medicine. My latest article in
@NatGeo
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Thank you
@mxwbio
for featuring our Down syndrome MS in this month's must-reads!!
@_graceor
#DownSyndrome
#astrocytes
#calciumimaging
Members of the
@LinTianLab
et al. including
@_graceor
investigated Down syndrome astrocytes and their ability to inhibit neuronal excitability in a stem cell model. Read more about this in Maxwell's Monthly Must-reads:
@biorxiv_neursci
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Great
@ucdavis
representation this year at the
@BRAINinitiative
investigators meeting! This year we had 5 PIs with BRAIN Initiative grants and 7 trainees attend.
@_graceor
@thejenjay
@JasonCDong1
@tpatriarchi
@JoeyBroussard6
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Congratulations!! A great advancement to the field!
Online now at Nat Meth, our near-infrared intensiometric Ca2+ indicator, NIR-GECO1 (). Only possible thanks to great collaborators
@eboyden3
,
@jinzhanglab
,
@RazanskyLab
,
@ERSchreiter
,
@thughesgfp
,
@Kirylpiatkevich
,
@Abdelfattah__A
,
@rosunna
, and others!!
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Our study of Down syndrome astrocytes and its ability to inhibit neuronal excitability.
@_graceor
#CellPressNews
#DownSyndrome
#astrocytes
#iPSCs
Cell Press - Sneak Peek -
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Congrats to our postdoc
@ElizabethKUnger
for being named a 2018 Mistletoe Research Fellow!
@mistletoefound
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Great to be a part of this exciting work! And also with
@gracemizuno
. Looking forward to continue to optimize this sensor!
I'm thrilled that this work, led by
@sa_melzer
, and in collaboration with
@LinTianLab
is out! This has been a monumental effort overs years. Sarah is truly an amazing postdoc.
Bombesin-like peptide recruits disinhibitory cortical circuits and enh...
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Huge thank you to everyone who worked on this project with us!!
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Great resource for undergrads!
I've made my guide to reading scientific papers available as a downloadable PDF, since I've been overwhelmed with email requests for it. My apologies if you asked for a copy and didn't get a response. You can find it here:
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Glad to share our effort on engineering far-red fluorescent calcium indicators FR-GECO1a and FR-GECO1c. The new FR-GECOs have excitation and emission maxima at ~ 596 nm and ~ 644 nm, and excellent performance in cultured neurons.
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Excited to see
@SevenBiosci
and
@gracemizuno
use PsychLight for drug discovery!
Researchers
@LinTianLab
and
@DEOlsonLab
developed a PsychLight sensor that can be used in discovering treatments for mental illness and detect drug abuse. Learn more about how it identified a psychedelic-like drug without the hallucinogenic side effects:
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Well deserved! Congrats!
Congratulations
@VivianGradinaru
for winning the 2020
@Vilcek
Prize for Creative Promise in Biomedical Science
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Tommaso Patriarchi's Nanodelivery paper is now online! Congrats!!
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@carney_lab
@PhotonicsWest
Thank you, Randy! Actually just 10mins talk. I am part of 8 speakers :))
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@neurodaniela
@anne_churchland
@IlanaWitten
@KateWassum
@kaymtye
@KristinMBranson
@meganinlisbon
@triciajanak
@SaKrabbe
@stpntr
Honored and humbled to be on this list. inspired and motivated by all of you!
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@superkash
@naturemethods
@ucdavis
@HHMIJanelia
@LoogerL
Thank you, Tom. So much fun working with you on serotonin sensors.
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If you’re interested in doctoral-level opportunities, applications are also open for PhD positions!
For more info on the IMPRS PhD program & to apply, visit ⬇️
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@mohebial
@ElizabethKUnger
@LoogerL
Thanks, Ali. Hope it will be useful to image crosstalk between dopamine and serotonin combined with RdLight.
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Congrats to our graduate student
@_graceor
and post doc Liz Unger for being awarded a BRAIN initiative investigators conference trainee travel award!!
@BRAINinitiative
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@ryanjhcho
@naturemethods
@ucdavis
@HHMIJanelia
@LoogerL
Thank you, Ryan. Still miss those days working with you on dLight. Hope all is well!
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@RoseEDixon1
So sorry to hear that. Hope he recovers quickly and everyone has a safe trip home.
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@LoogerL
@ElizabethKUnger
Loren, Thanks for being a good mentor for me years ago and now an important collaborator!
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@jinzhanglab
@Facultyopinions
We’re honored and humbled. Thank you! This study is not possible without
@ElizabethKUnger
and a great team work.
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WOW! That's awesome!!!
Can’t wait for the
@USPS
2018 science-themed stamps, specially the
#bioluminescent
creatures series!! Featuring some amazing
#deepsea
animals including two
#polychaetes
!
#SciComm
#SciArt
#STEM
#STEMed
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@lienjao
@rhodamine110
@DEOlsonLab
@jenn_prescher
@lesterha
@ElizabethKUnger
@AltermattMi
@JasonCDong1
@olivia_hon
@gracemizuno
Thank you, Li-en!
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Very true.
“Never be afraid to recruit people brighter than you and...different than you. That is...incredibly powerful if you want to create a team that is really effective.”
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@lfsantana68
@lienjao
@rhodamine110
@DEOlsonLab
@jenn_prescher
@lesterha
@ElizabethKUnger
@AltermattMi
@JasonCDong1
@olivia_hon
@gracemizuno
Thank you, Fernando!
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In memory of Ben Barres, a personal tribute | Notes from the Quad
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So proud of you! Excellent work!
but sometimes I think that's all you need to keep a dream alive. Thank you
@NSFSBIR
for believing in the technology and this PhD graduate turned aspiring biotech entrepreneur. (3 of 3)
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@KharaRamos
thank you! we are grateful that BRAINI allowed high-risk, high-reward and multi-group collaborations that are otherwise difficult with other funding mechanisms.
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