Lin Tian, PhD
@LinTianPhD
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Scientific Director @MPFNeuro | Developing optical & molecular tools for 🧠 research & 💊 discovery | Baseball mom, swim mom & dog mom
Jupiter, FL
Joined December 2017
Our sensor for serotonin, iSeroSnFR, has enabled us to gain a much deeper understanding of the psychoactive effects of psychedelics, allowing us a path toward developing more effective treatments for disorders like anxiety.
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Thanks to @DianaMKwon & @Nature for featuring our work in this piece on genetically-encoded sensors. The article does a great job highlighting their importance for both basic research and translational impact, such as in our lab's research on serotonin. https://t.co/epOuDrjn8e
nature.com
Nature - Tools that track specific molecules in neurons have enabled researchers to probe previously unexplored aspects of neurobiology — although important caveats remain.
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The Tian Lab is headed to San Diego for #Sfn25! Proud to have Postbac Fellow, @landondlee representing us this year––if you’re attending, be sure to stop by his poster to hear more about the science we've been developing this year! ☀️🧠
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@LakeConferences @AllenInstitute Thanks to Karel Svoboda for the invitation and for putting together a great symposium!
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How has the way we study neural coding and dynamics changed? At the recent @LakeConferences hosted by @AllenInstitute I was able to share ideas and research with others working toward new experimental & computational methods for studying these dynamic systems over time.
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Our latest led by @TVKamath with important contributions by collaborators including Nao Uchida, Mitsuko Watabe-Uchida and @LinTianPhD Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum: Neuron
cell.com
Kamath et al. examine the neural mechanism by which hunger makes animals take more risks. They show that hunger neurons in the hypothalamus suppress threat and salience-related dopamine signals in...
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This week is National Postdoc Appreciation Week, and we couldn't be prouder of our postdocs in the Tian Lab! ✨ Our postdocs drive forward research, plan and lead projects, mentor students, present and publish work, and much more. I am grateful for you every day! #NPAW2025
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Thinking about attending Sunposium 2026? Now is the time to act! The early bird registration deadline is September 19th. Curious what makes this conference so special? Our video will give you a glimpse: https://t.co/Qcn642UBqV Join us March 9–11, 2026, in sunny South Florida.
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💡 The future direction of these sensors goes beyond optimization. We want to combine sensor use with technology such as fiber photometry in order to measure the full range of dynamics such as tonic and phasic neuromodulator release. Learn more here⬇️
lintianlab.org
Lin Tian's Lab invents, optimizes, and shares innovative molecular tools and biosensors with the ultimate goal of uncovering new treatments for neuropsychiatric diseases.
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🔎 We optimize for signal to noise ratio, measuring intrinsic properties: dynamic range, dissociation constant (Kd), frequency & concentration of signaling molecules.
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At a recent lecture I gave at @CSHANews, I used our calcium indicator as an example to illustrate how we design these sensors. 📈 Optimization is key.
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The brain has complex dynamics that give rise to a range of states & behaviors. 🤔 How do we study this complex system? In my lab’s work, we design and optimize biosensors to measure brain activity at the molecular level.
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I attended the first ever Neurobiology of Psychedelics @GordonConf last month. I was impressed by how interdisciplinary the field is, from molecules to humans. We are just starting to understand the mechanisms of these drugs and how they can unlock future treatments.
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They celebrated with a poster session last week highlighting what they learned. We are so proud of them and their contribution to advancing brain research. Thanks also to their mentors, Yiwei Hua, Julie Chouinard, and Erin Scott!
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Congratulations to our three wonderful interns who joined us in the Tian Lab this summer, working on optimizing our PsychLight methodology to screen for potentially therapeutic compounds with similar mechanisms to psychedelics. https://t.co/PqYOOHCADr
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The Tian Lab looks forward to welcoming high school students each year as a part of @MPFNeuro's summer internship program! We’re thrilled to have Olivia & Nicole join us this summer and to be part of their journey as they explore what a future in neuroscience can look like.
Meet MPFI's 2025 High School Internship cohort! These seven talented students have been working alongside our researchers this summer on projects in neuroscience, programming, or mechanical engineering. Read more about these talented students in our latest blog post:
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I recently spoke about my lab's newest sensors at @EMBLEvents's European Light Microscopy Initiative meeting 🔦 🧠 Sharing progress with the community is key to moving science forward, which is why these sensors, and all our tools, are open source ➡️ https://t.co/eW1cr5wyNB
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What a joy to celebrate Nikki, @jin_jinyihanmg & @kiranlongiyer at @UCDavis commencement 🎓 As Chancellor May said, the world needs minds like yours more than ever & I’m so excited to see the impact you’ll make in the years ahead. Congratulations on this incredible milestone!
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Our next #InterfaceNeuroGT session highlighted cutting-edge techniques for measuring and manipulating sensorimotor and cognitive behavior — across species and across scales. Sponsored by @ParkinsonsGT and chaired by @DrACSinger.
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Please Share! Nominations are open for the Peter Gruss Young Investigator Award! This award celebrates early-career scientists who have made outstanding contributions to the scientific community through collaboration, creativity, and curiosity-driven research. Know someone doing
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