Andrew Luskin
@aluskin
Followers
199
Following
287
Media
2
Statuses
88
RT @mouse_braind: Thrilled to announce that our paper is now finally out! 🎉We combine scRNAseq, 2p imaging, ephys, and behavior to understa….
0
20
0
RT @Nature: Nature research paper: Heterogeneous pericoerulear neurons tune arousal and exploratory behaviours.
nature.com
Nature - A set of neurons in the peri-locus coeruleus region controls arousal and avoidance states, providing an understanding of the neurobiological basis of arousal and exploratory behaviours.
0
24
0
@dilithium21 @mbruchas @_MadisonMMartin @kelseybarcomb @mouse_braind @gstuber @GuLiangcai Institutes include @UWAnesthPainMed, @UWPharmacology, @UWproteindesign, @seattlechildren, @UWPsychology , @UWBiochemistry, @CUAnschutz, @BioStructureUW - thank you all for making this possible!.
0
0
8
@dilithium21 @mbruchas @_MadisonMMartin We worked on electrophysiology with @kelseybarcomb and Chris Ford; single-cell sequencing with @mouse_braind and @gstuber, spatial sequencing with Xiaonan Fu, Li Sun, Lei Gao, and @GuLiangcai; and 3-D imaging with Alexandria Murry and Sam Golden.
1
0
9
This was a huge collaboration with co-first @dilithium21, PI @mbruchas and the rest of the lab, including @_MadisonMMartin, Kasey Girven, Taylor Blackburn, Bailey Wells, Sarah Thai, Ether Li, Akshay Rana, and many more.
1
0
6
Based on this data, we looked at subpopulations of peri-LC neurons, and we found that they have different activation patterns and different effects on the LC, showing that they can contribute to different facets of cognitive arousal.
1
0
6
We performed single-nucleus sequencing and spatial RNA sequencing of the LC and peri-LC and discovered a rich variety of neurons in both regions, uncovering pathways important for sleep disorders, opioid use, mood disorders. .
1
0
9
Strangely, the peri-LC is activated by many of the same stimuli as the LC itself, and we suspected that just like the LC, the peri-LC is not one simple structure.
1
0
7
The LC core is wrapped in a group of mostly inhibitory neurons called the peri-LC. The peri-LC inhibits the LC, causing pauses and bursts in LC firing, and it affects arousal-related behavior, including exploration, feeding, anxiety, and pain response.
1
0
7
But how is the LC itself controlled, and how are these heterogenous circuits and firing patterns established and coordinated?.
1
0
6
Recently, researchers have found that the LC is highly diverse and has different firing patterns that have distinct effects on other brain regions, tuning the rest of the brain up and down.
1
0
6
The LC is a tiny blue crescent in the brainstem that releases most of the norepinephrine across the brain - it is a central controller of cognitive arousal, affecting everything from anxiety to sleep to mood to attention.
1
0
8
New paper on arousal in the brain! What controls the controller?
4
18
76
RT @rcatsimon: Excited to share that my graduate dissertation work is now finally live on bioarxiv! Take a look if you're interested in lea….
biorxiv.org
Because opioid withdrawal is an intensely aversive experience, persons with opioid use disorder (OUD) often relapse to avoid it. The lateral septum (LS) is a forebrain structure that is important in...
0
20
0
RT @iamhans: New paper alert! Our work on the extra-amygdalar panic circuit has been published @NatureNeuro. Congrats to co-first authors @….
nature.com
Nature Neuroscience - Panic disorder is characterized by uncontrollable fear accompanied with unique somatic symptoms. Kang, Kim et al. identify a pontomesencephalic PACAP pathway that plays a...
0
39
0
RT @PiantadosiSean: Happy to share my @mbruchas lab work in @NeuroCellPress. Holographic stimulation to manipulate amygdalar valence ensemb….
0
71
0
RT @DGlaucomflecken: @Lymphoma_Doc Please forgive me, I was mercilessly ridiculed by an IRB at a very early age.
0
5
0
RT @josueregalado96: How do we stay motivated as we learn, such as when we study for a test? 📝😰. Our new paper, now on biorxiv, suggests th….
0
24
0