stephen o'rahilly (its pronounced O-RA-hill-EEE)
@StephenORahilly
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Physician-scientist interested in the causes and adverse consequences of obesity. Director MRC Metabolic Diseases Unit, University of Cambridge. Views mine.
Cambridge, England
Joined May 2011
RT @BevJacksonAuth: Fantastic piece by @HadleyFreeman on Scotland’s madness:. “But, of course, ‘hate speech’ in this particular context mea….
thetimes.com
Nicola Sturgeon still can’t bring herself to say a convicted rapist is a man
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RT @JohnBoyneBooks: I've remained silent over the last week with regard to the @PolariPrize as I wanted to get my thoughts in order. Many….
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Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism: Cell Metabolism
cell.com
Hansford et al. show that GIPR, a target of new weight-loss drugs, is found in brain cells called oligodendrocytes. GIPR helps these drugs access the brain and boosts weight loss. Without GIPR in...
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It does seem extraordinary that this story is not generating greater interest in Australia. The judgment will have huge human rights implications.
Australians are not hearing too much about this case. It’s one of the most important cases out there and no one is hearing about it. Please share the story. If this gets a lot of attention others will want to cover it.
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RT @DalgetySusan: On 15 August it’s 4 years since Taliban re-took Afghanistan and began its systematic oppression of women. We must all do….
scotsman.com
As Susan Dalgety listens to young Afghan women describe how they have been all but erased from society, she begins to cry. But her tears soon turn to anger
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RT @jk_rowling: Being a woman isn't an essence, it's a material, provable fact. I'm not a female human being because society or history mad….
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Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine Early days, but this looks pretty exciting.
nejm.org
The need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically m...
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Shared with you by a Times subscriber. Enjoy this article for free. I encourage anyone interested in humanity and decency to read this beautifully crafted piece. @VictoriaPeckham.
thetimes.com
Case of Sandie Peggie reveals a working-class woman being hounded by doctors and managers for wrongthink on trans ideology
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and are in the late stages of planning a trial of metformin in prevention. UK science can be proud of its critical contributions to this underresearched area.
As the author #abistephenson appears to be UK-based she will be pleased to know that, in collaboration with @DrFejzo , UK scientists led on making some of the key discoveries she mentions in her piece, are currently contubuting to trials of a novel GDF15 blocking therapy/.
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As the author #abistephenson appears to be UK-based she will be pleased to know that, in collaboration with @DrFejzo , UK scientists led on making some of the key discoveries she mentions in her piece, are currently contubuting to trials of a novel GDF15 blocking therapy/.
Thanks to #abistephenson for sharing her terrible experience of this disorder so affectingly.
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Thanks to #abistephenson for sharing her terrible experience of this disorder so affectingly.
theguardian.com
The long read: The Victorians called it ‘pernicious vomiting of pregnancy’, but modern medicine has offered no end to the torture of hyperemesis gravidarum – until now
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Britain is not a broken society via @ft Worth a read as an antidote to gloom.
ft.com
The country has serious problems but the right’s vision of it has become hysterical
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Insightful and cogent as always.
A large number of people (mostly men, in my experience) who're sympathetic to some of women's opposition to gender identity ideology, nevertheless think it's cruel to point out that a trans-identified man looks like a man, and unkind not to 'respect' his pronouns. They think
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RT @aifbw: This explains it very well. I love the "How very dare you. " comment from Upton. Well he is going to have to toughen up if….
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I would be interested to know the best evidence that GLP1RAs improve insulin sensitivity in humans independently of their effects on energy balance. Pls share relevant PMIDs.
@sciqst @StephenORahilly Definitely. Reduced inflammation and improved insulin sensitivity are key ways GLP-1s support overall metabolic and liver health.
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This is stunning.
Marvin Gaye’s voice isolated from music. «I heard It through the grapevine», 1967.
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Or maybe just the signature of unloading fat from the liver by successfully putting people into negative energy balance and keeping them at a stable healthier balance ? Jury is still out I think.
The anti-inflammatory power of semaglutide (Ozempic) seen by its normalization to healthy of a 72 protein signature tied to MASH liver disease.@NatureMedicine
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via @ft. This identifies the biggest problem with post grad uk med specialist training. Its duration. An international outlier, particularly damaging for those trying to become clinician-scientists.
ft.com
An overly long NHS training period is partly what’s causing the strikes and exodus of medical staff
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RT @SexMattersOrg: Sex Matters’ CEO Maya Forstater (@MForstater) responds to NHS Fife tribunal statement:
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