Roman Sankowski
@r_sankowski
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#stopTheWar🇺🇦 Physician scientist working in neuropathology @ PrinzLab opinions are mine #immunology #cancer #glioblastoma #immunotherapy #scRNAseq #neuropath
Freiburg im Breisgau
Joined November 2014
Our #OpenAccess paper on human CNS #macrophages went online today. It was a multi-year collaborative effort between clinician scientists from #Neuropathology #Neurosurgery #Oncology and #gynacology. It struck with the question: what are the phenotypes of human CNS macrophages? /1
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10 Python Books for FREE on this Christmas Eve 🎄
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Math for #MachineLearning and #Artificialintelligence — FREE 479-page PDF eBook on The #Mathematics & #Statistics Foundations of #DataScience here:👉 https://t.co/ldOEOioBu7 👈 ———— #AI #DeepLearning #ML ———— ➕ Also see this #NeuralNetworks book: https://t.co/jdR4E8cy1r ⬇️
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Biggest medical discoveries of the week (🧵) 1/8 AI for drug discovery Generative AI was used to produce selective protein antagonists of the pro-inflammatory TNF receptor, TNFR1, that do not bind TNFR2 (which is anti-inflammatory) This could improve the anti-inflammatory
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There were 4 new FDA approvals in November (🧵) 1. Zanidatamab, the first approved antibody that targets two epitopes in the same molecule (HER2) It got accelerated approval, for HER2-positive biliary tract cancer, based on this single-arm trial ( https://t.co/TyMMoD289U)
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⚡️📣After the success of our previous pathology foundation models UNI ( https://t.co/C3YXYFNkG4) and CONCH ( https://t.co/m2RRCfRsCu), we are now announcing TITAN ( https://t.co/5TvzirNHjC), a new state-of-the-art whole slide level foundation model trained on >330k pathology slides
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Another week another list of #research highlights by @SamuelBHume
Biggest medical discoveries of the week (🧵) 1/8 A malaria vaccine - attenuated P. falciparum arrested in the late liver stage - provided 89% protection in a trial of 9 people This could improve the modest, short-lived protection of current vaccines https://t.co/BktXfVBcLx
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Atlas of the plasma proteome in health and disease in 53,026 adults: Cell #paper
cell.com
A large-scale proteomics study involving 53,026 individuals maps 2,920 plasma proteins to 406 prevalent diseases, 660 incident diseases, and 986 health-related traits, identifying promising biomark...
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Identifying spatially variable genes by projecting to morphologically relevant curves | bioRxiv #paper
biorxiv.org
Spatial transcriptomics enables high-resolution gene expression measurements while preserving the two-dimensional spatial organization of the sample. A common objective in spatial transcriptomics...
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Honored to be recognized as #HighlyCited2024 - quite a validation for my early career as #clinicianScientist thank you to the funding agencies including Fritz Thyssen Stiftung @BMBF_Bund @EKFStiftung
7 Freiburger Wissenschaftler sind Highly Cited Researchers 2024, d.h. Autoren, die im vergangenen Jahrzehnt weltweit in ihren Forschungsfeldern am häufigsten zitiert wurden. https://t.co/eYMloT2N2S
#HighlyCited2024 @Uniklinik_Fr @cappenberg @meerpohl @r_sankowski @LSchwingshackl
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Adipose tissue retains an epigenetic memory of obesity after weight loss | Nature #paper
nature.com
Nature - Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially...
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Great #scientific #discoveries of the week
Biggest medical discoveries of the week (🧵) #1 - Evo: generative AI for biology From scratch, Evo could: Design a functioning CRISPR-Cas enzyme (top right figure) Predict gene essentiality at genome-wide scale (bottom left figure) Generate genome-length DNA sequences,
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Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord | bioRxiv #paper
biorxiv.org
Development of therapeutic approaches that target specific microglia responses in amyotrophic lateral sclerosis (ALS) is crucial due to the involvement of microglia in ALS progression. Our study...
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Mechanisms driving epigenetic and transcriptional responses of microglia in a neurodegenerative lysosomal storage disorder model | bioRxiv #paper
biorxiv.org
Lysosomal dysfunction is causally linked to neurodegeneration in many lysosomal storage disorders (LSDs) and is associated with various age-related neurodegenerative diseases[1][1],[2][2], but there...
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Biggest medical discoveries of the week (🧵) 1/8 In a world first, induced pluripotent stem cells restored vision in 3 patients with limbal stem-cell deficiency (LSCD) LSCD is loss of the stem cells that replenish the cornea, and can be caused by trauma, autoimmunity or
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Where the next #pandemic will come from - Global expansion of wildland-urban interface intensifies human exposure to wildfire risk in the 21st century | Science Advances #paper
science.org
Global WUI distributions in 2000, 2010, and 2020 uncover the surge of potential exposure risk to wildfire.
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Human DNA polymerase ε is a source of C>T mutations at CpG dinucleotides | Nature Genetics #paper
nature.com
Nature Genetics - A new method called polymerase error rate sequencing (PER-seq) can measure the nucleotide misincorporation rate of DNA polymerases. DNA polymerase ε mutants produce an excess...
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Origins and impact of extrachromosomal DNA | Nature
nature.com
Nature - A study examines the diversity of extrachromosomal DNA elements in cancer, and provides details on the frequency and origin of extrachromosomal DNA and its role in the development of...
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Automated real-world data integration improves cancer outcome prediction | Nature #paper
nature.com
Nature - A study generates a clinicogenomics dataset resource, MSK-CHORD, that combines natural language processing-derived clinical annotations with patient medical data from various sources to...
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