Nowakowski_Lab
@LabNowakowski
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Developmental neurobiologist, using integrative high throughput technologies to study how the cerebral cortex is constructed.
San Francisco, CA
Joined July 2018
Excited to share our review of brain development, focusing on what is known about the emergence of cortical areas. Great work by @crcadwell @mohammedmostajo , Aparna Bhaduri and Matt Keefe https://t.co/hNK9L747fN
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NIH looking to fill positions to Direct 14 of our Institutes and Centers. It's a once in a lifetime opportunity to advance science in your field on a national level.
The NIH has additional opportunities available for exceptional senior-level candidates to lead Institutes and the Intramural Research Program within the NIH. These leadership roles provide overall executive direction and scientific leadership for the Institutes mission and
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Scientists complete first drafts of developing mammalian brain cell atlases. Learn more: https://t.co/vRvqyLcySw
#studyBRAIN
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Less than two weeks left to register for the inaugural conference on Assembloids & Complex Cell-Cell Interactions @CSHL Check out the topics and amazing lineup of speakers! 👇
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What an exciting time for brain mapping 👇🏻👇🏻👇🏻
@E11BIO is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. We discovered
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Apply by Oct 15 - please spread the word!
Tenure-track faculty search of the @Ucsf_Biochem Department is open for applications! We are looking for creative, innovative scientists asking fundamental questions in any area of biology. Join our vibrant, collaborative, and supportive community! https://t.co/o8SJlLNNlg
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📢 We're hiring a PhD student! Join the @GLB_Lab (IN-UMH/CSIC; @NeuroAlc) to explore how spontaneous neural activity and genetic programs shape sensory cortical development. Funded by @AgEInves. https://t.co/VLbqCRKo0r
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@AdamMarblestone and I explore how we may design safer AI systems and improve brain health by applying new brain mapping technologies -- including new microscopy and AI tools from @E11BIO. Also check out the rest of this essay series on emerging technologies hosted by @IFP 👇
2. @AdamMarblestone & @Andrew_C_Payne on how to map the mammalian brain’s connectome to solve fundamental problems in neuroscience, psychology, and AI robustness:
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Congratulations Dena and team!!!
"We could all use a little more X!" Thrilled our new study is out. Aging "wakes up" the silent X chromosome in the female brain - and this contributes cognitive resilience. Spearheaded by @MargaretGadek in @ScienceAdvances Collaborators Berenice Benayoun, @BBParis1984
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We are looking for talented postdocs to join our team at @StanfordBrain @StanfordMed @StanfordNsurg! Join us to develop single cell sequencing- and imaging-based genomic tools to understand the cell communication across space and time! Please share with anyone interested!!
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We are accepting applications for speakers from Native American trainees - if you know of someone who would be a good fit, encourage them to apply here: https://t.co/0mDbkA1Msc PS: We have travel funds available! Plz share! More info in the thread.
We will be hosting 3rd Full Circle Symposium for Native Biologists hosted at UCSF in April 2025! We aim to build community and provide opportunities for Native biologists. If you are a Native biologist who is interested fill this out to stay up to date: https://t.co/0Z5TqcNfwk
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Super cool science from my colleagues at UCSF- mutational scanning uncovers mechanisms of pH sensing by GPCRs
Check out our work, where we discover how receptor GPCR senses pH! We develop foundational GPCR DMS tech dev + structural bio that will have impact across historically intractable receptor systems! Led by brilliant PhD student @matthewkhoward and Nick Hoppe w/ @AashishManglik!
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👇🏻👇🏻👇🏻
Our latest work in collaboration with the Bourhy Lab (Pasteur Inst.) in which we use scRNA-seq to characterize host-rabies molecular interactions across diverse human brain cell types. Recommended if you're interested in "system virology" or glial biology:
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Spotlight on Single-Cell Genomics! We (@ozgungokce , @bayraktar_lab, @naomi_habib, Genevieve Konopka, @LiddelowSA , and @LabNowakowski) collaborating with top neuroscientists to explore optimizing these technologies: 🔗
nature.com
Single-cell and single-nucleus genomics pave the way for a comprehensive understanding of the nervous system and its diverse cell populations. Realizing this...
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👇🏻👇🏻👇🏻
We are looking for a postdoctoral fellow to join us to study somatosensation development and function! I’m committed to the training and success of my trainees. Please help me spread the words!
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👇🏻
4/14 We used human hippocampus from patients who had brain surgery for refractory epilepsy. We sliced samples and transduced them on day 0, and our custom tissue-prep pipeline allowed for our high-density MEA recording experiments after up to 8 days in tissue culture.
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Excited to share new study from the lab, work led by @JohnPAndrews_MD and grateful for all the collaborators who made this possible including @ChangLabUcsf @ucscgenomics
Today in @NatureNeuro, researchers led by @LabNowakowski, @ChangLabUCSF & Mircea Teodorescu (@ucscgenomics) demonstrate the first use of optogenetics to modulate seizure activity at the network level in human brain tissue: https://t.co/GquVhx1axa
@JohnPAndrews_MD @UCSFstemcell
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Glad to share the peer-reviewed version of the @mgheffel manuscript now in @Nature. In collaboration with @lab_paredes , we studied the chromatin conformation and DNA methylation changes during human hippocampus and frontal cortex development.
nature.com
Nature - Using a single-nucleus multi-omics approach, a study jointly profiles the reorganization of the epigenome and the three-dimensional chromatin conformation during the development of the...
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Fate plasticity of interneuron specification https://t.co/rErAVgki8c
#biorxiv_neursci
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Congratulations to graduate students @dmshin14 and @MEUrbanek for their recent preprint describing nuclear sequencing compatible barcoded rabies libraries for circuit mapping. See twittorial and preprint
biorxiv.org
Single cell genomics has revolutionized our understanding of neuronal cell types. However, scalable technologies for probing single-cell connectivity are lacking, and we are just beginning to...
Very excited to announce the release of our preprint “High-Complexity Barcoded Rabies Virus for Scalable Circuit Mapping Using Single-Cell and Single-Nucleus Sequencing” on bioRxiv! 🧵
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