Aashish Manglik
@AashishManglik
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@UCSF Associate Professor | G protein coupled receptor aficionado
San Francisco, CA
Joined June 2014
RT @aaronmring: You’ve heard of vibe coding—meet vibe protein design. Click, launch, and watch the binders roll in. That’s what we're unvei….
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I am so incredibly lucky to get to work with brilliant postdoc @JoseAVelilla2. Jose is taking on some of the most ambitious ideas that Mark and I dreamed of collaborating on for years - the @HHMINEWS Hanna Gray fellowship will enable him to dream ever bigger!.
Thrilled to share that I was named a Hanna Gray Fellow! It is an honor to join this community with so many of the superstars I admire. Very grateful to @HHMINEWS for their continued support and to my fabulous mentors @AashishManglik, Mark Von Zastrow, and @RachelleGaudet.
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RT @CorneliusGati: Excited to share our work on GPCR antagonism: Contrary to popular belief, inverse agonists can bind to and act via GPCR:….
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Please check out our recent work led by brilliant student @matthewkhoward jointly mentored with @willowcoyote. Willow and I are recruiting joint postdocs!.
Happy New Year! Excited to share the final version of our work where we combine deep mutational scanning, cryo-EM, and molecular dynamics to further resolve the mechanisms of pH sensing in GPCRs. 🧵(1/n).
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RT @IshanDeshpande: Thrilled to share our findings on NINJ1 autoinhibition, now online in @Nature. Big thanks to the amazing team @dixitvis….
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RT @DavideCalebiro: Two exciting #postdoc opportunities for #microscopy #developers and #biologists to join our team @COMPARE_UoBUoN @unib….
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RT @nicolemfish: Excited to share a new preprint about my postdoc work in the von Zastrow lab! Using conformational biosensors, we investig….
biorxiv.org
Many GPCRs initiate a second phase of G protein-mediated signaling from endosomes, which inherently requires an increase in G protein activity on the endosome surface. Gs-coupled GPCRs are thought to...
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RT @deboramarks: @ylecun @ATinyGreenCell Although you don't cite our critical paper (same time) where we showed you could fold into correct….
journals.plos.org
The evolutionary trajectory of a protein through sequence space is constrained by its function. Collections of sequence homologs record the outcomes of millions of evolutionary experiments in which...
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We are recruiting a young researcher to join our dynamic lab at UCSF - this is a great opportunity if you would like to get some research experience before graduate or medical school! Please RT!.
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RT @The_Ban_Lab: In our new study we reveal how NAC coordinates and regulates successive co-translational nascent chain ⛓️ processing on th….
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RT @UCSF: How do cells communicate? UCSF's @AashishManglik explored cellular communication through specialized protein receptors at the 29t….
ucsf.edu
Aashish Manglik delivered the 29th annual Byers Award Lecture titled “Signal Reception: Cracking Codes in Cellular Communication.”
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RT @hollyingrahamSF: Scientists Discover a New Hormone that Can Build Strong Bones | UC San Francisco . Thank you @LauraKurtzman for a gr….
ucsf.edu
A newly discovered hormone explains why females can maintain bone density during lactation, when calcium is stripped away to make milk. This discovery could one day have applications to treating...
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RT @Anat_Levit: Our new paper on structure-based discovery of novel CFTR potentiators via large-scale docking is out in Cell!. https://t.co….
cell.com
Large-scale library docking and structure-based optimization are used to identify CFTR modulators, which include a nanomolar potentiator with promising pharmacokinetics and inhibitors that bind to...
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RT @hhokamoto_en: I am truly honored to receive the @HFSP long term fellowship (LTF) 🥳.I'll be working with @AashishManglik as a postdoc @U….
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RT @rhuttenhain: So excited to see our work on "Profiling the proximal proteome of the activated μ-opioid receptor" using APEX-based proxim….
nature.com
Nature Chemical Biology - A proteomics and computational approach was developed to map the proximal proteome of the activated μ-opioid receptor and to extract subcellular location, trafficking...
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RT @aaronmring: Ever wonder how microbes interact with the host at a molecular level? Check out our latest paper in @nature with Noah Palm….
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RT @QBI_UCSF: Excited to welcome Carol Robinson, Dr. Lee’s Professor of Chemistry at @UniofOxford & Director of Oxford’s Kavli Institute fo….
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RT @Stanford_MCP: Today we remember and celebrate the life of Bill Weis. Our friend, colleague, & mentor. We scientists are lifelong lear….
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RT @UCSFHospitals: What's next for Dr. @AashishManglik, winner of the 2024 Bowes Biomedical Investigator award? The cell signaling expert s….
ucsf.edu
Biophysicist Aashish Manglik, MD, PhD, is the newly awarded 2024 Bowes Biomedical Investigator. With the award, he hopes to further the intersection of his GPCR research and neuropsychiatric diseases.
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