Omer Ali Bayraktar
@bayraktar_lab
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Group leader at @sangerinstitute Neural diversity, spatial transcriptomics, glia, GBM https://t.co/AGAGRUasuI…
Joined April 2018
Which human brain circuits are implicated in neurodevelopmental conditions? We bridged human genetics, spatial transcriptomics and neurodevelopment to discover the convergence of autism-associated genes in the developing human thalamus! https://t.co/2GIBjLMz0w
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Happy to have helped with this great project on expression patterns of autism-associated genes in developing brain, led by @bayraktar_lab, showing surprising enrichment in the thalamus. https://t.co/HYfruOfej7... Genetics analyses in @SPARKforAutism by @mahmoudkokomusa.
Which human brain circuits are implicated in neurodevelopmental conditions? We bridged human genetics, spatial transcriptomics and neurodevelopment to discover the convergence of autism-associated genes in the developing human thalamus! https://t.co/2GIBjLMz0w
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Grateful to @hilsomartin, Tom Nowakowski and many other authors (which I could not @ because the auto suggests here are now terrible!)
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3) Our work suggests thalamocortical circuit development is a major hub of autism susceptibility & organoid/animal models of autism need to take this into account
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2) Hyper/hypo sensitivity are amongst core autism symptoms and sensory sensitivities can be highly distressing & impair social communication.
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Why is this important: 1) Thalamus is a brain region essential for sensory processing and social cognition. It is deeply & reciprocally connected with the cortex, where information from your senses is relayed to the cortex through the thalamus.
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After the thalamus, the germinal zones that house neural progenitors are most heavily implicated, especially interneuron progenitors! See the preprint for more!
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We implicated thalamic excitatory neurons in particular, and many of the thalamus expressed genes are involved in neuronal & synaptic function.
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While we expected the developing human cortex to be the most “important” region, we found the most prevalent expression of autism susceptibility genes in the developing human thalamus!
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Here, we mapped the expression of 250 known autism susceptibility genes in >10 million cells across the developing human forebrain using Xenium spatial transcriptomics
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by looking them up in single cell transcriptomic atlases of the developing human brain. However, neuroscience is very “cortex-centric” - it is the most accessible & widely studied brain region - neuroimaging & behavioural symptoms implicate other brain areas.
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When & where are these genes expressed during human brain development? These are key questions towards understanding the biology of profound autism. Previous work suggested that autism susceptibility genes converged in the developing human cerebral cortex...
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Autism is also highly heritable. In >10% of autistic individuals, rare & de novo coding genetic variants (i.e. leading to loss of protein function) predispose individuals to profound autism. We know of >200 “autism susceptibility genes” with such variants.
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First & foremost, autism exists across a wide spectrum. Our work is focused on profound autism that co-occurs with developmental and intellectual disability (e.g. non-verbal / minimal communication).
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Work by the awesome team of Alexander, @FaniMemi @koenrademaker. Explore the data interactively (>10 million cells spatially mapped across the developing human brain):
stageatlas.org
Single-cell and spatial transcriptomics datasets can be interactively navigated and downloaded on this portal.
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A new dimension of genomics is here. Spatial transcriptomics is transforming how we understand tissues – revealing where genes act, and why it matters. 🧬 Try our spatial-inspired game before reading the latest blog 📷 https://t.co/405vaAC4w3
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🚀 Looking for a Bioinformatician / Data Scientist to join our crew and explore regeneration through single-cell genomics & evolutionary biology! 📩 Questions? Contact us ✉️ 🔗 Apply here:
mpg.de
Job offers of the Max Planck Society and Institutes. You can combine the "jobtype" with either "research subjects" or "region". Confirm your choice with OK.
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Experts have found that chromosomes of the Atlas blue butterfly were split up over the last 3 million years, leading to 229 pairs. 🦋 This confirms that it has the highest number of chromosomes out of all animals, and now, researchers can explore why. https://t.co/HmqrB5mt2R
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🚨 2 × PhD positions @EPFL @epflSV! Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne 🇨🇭. Start Jan 2026. Send CV + motivation + 2 refs → fschueder@ethz.ch #PhD #Hiring #microscopy #SpatialOmics #DNAPAINT #FLASHPAINT
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We have developed MouseMapper AI, a deep learning ensemble for the analysis of whole-body systems, including the nervous and immune systems, to map disease/drug perturbations tissue by tissue, organ by organ, at the cellular level in 3D. MouseMapper uncovered obesity-induced
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