Omer Ali Bayraktar
@bayraktar_lab
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Group leader at @sangerinstitute Neural diversity, spatial transcriptomics, glia, GBM https://t.co/AGAGRUasuI…
Joined April 2018
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. atlassing & predict plasticity w. snRNA/ATAC+deep learning 🧵
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RT @FSchueder: 🚨 2 × PhD positions @EPFL @epflSV! Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & sp….
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RT @erturklab: We have developed MouseMapper AI, a deep learning ensemble for the analysis of whole-body systems, including the nervous and….
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RT @mo_lotfollahi: (1/12) Over a year ago, we launched a new project to explore whether the tissue microenvironment could predict cellular….
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RT @AkbarSAhmed: NEW—"A lot of children have passed the point of no return. The gut lining has started to auto-digest & will no longer [ab….
huffpost.com
"In August and September, there are probably still going to be ... large numbers of deaths because children have already passed the tipping point," Mark Brauner, who volunteered in Gaza last month,...
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RT @JeremyKonyndyk: As a longtime humanitarian who has battled famines and hunger crises, I fear that starvation in Gaza has now passed the….
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RT @dilekopter: Happy to share our new study from my PhD on the spread of farming across Anatolia and into the Aegean and then into Europe.….
science.org
West Anatolia has been a crucial yet elusive element in the Neolithic expansion from the Fertile Crescent to Europe. In this work, we describe the changing genetic and cultural landscapes of early...
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RT @hana_aliee: I'm honoured to join @CRUK_CI and @Cambridge_Uni as a Junior Group Leader of AI for Cancer. My group will focus on reasonin….
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RT @DervisSalih1: We are happy to be seeking three post-docs across Edinburgh Napier, Glasgow & UCL in an exciting project to investigate m….
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RT @sangerinstitute: Huge congratulations to Sam Behjati who has been elected as a Fellow of the Academy of Medical Sciences 🎉. Sam’s work….
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RT @bayraktar_lab: How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 studies, we trace #glioblastoma het….
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RT @ahmet_rifaioglu: Great effort by @bayraktar_lab, @StatGenomics & @MoritzMall labs in unravelling GBM cell state variability and spatial….
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RT @MoritzMall: What keeps cancer cells in check—and can we tame hem? In 2 collaborative preprints, we trace glioblastoma cell transitions….
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Grateful to >60 authors for their amazing work + @WellcomeLeap (special thx to @jrswedlow for leading DeltaT!) & @cziscience for their support. @emblebi @cricklab @Cambridge_Uni @DKFZ @sangerinstitute.
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Finally, you can access & navigate almost all of our GB single cell and spatial data in our portal @ built with webatlas2 (.
gbmspace.org
Single-cell and spatial transcriptomics datasets can be interactively navigated and downloaded on this portal.
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There are many implications & LOTS of detail in the preprints (e.g. mesenchymal cancer states is really a gliosis/hypoxia response & GB tumour subtypes are likely confounded)
biorxiv.org
Glioblastoma (GB) is one of the most lethal human cancers, marked by profound intratumoral heterogeneity and near-universal treatment resistance. Cellular plasticity, the capacity of cancer cells to...
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Taken together, these 2 studies start to unveil what I call the “rules” of glioblastoma. Despite their incredible complexity, these tumours are governed by specific cellular & tissue mechanisms. We believe/hope this understanding will be a foundation for new therapies
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In GB, as opposed to unrestrained plasticity of cancer cells, we predict transition highways and barriers aligned with paper 1. And we mechanistically validate a transcriptional repressor safeguarding neuronal like cancer states!
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scDORI enables us to examine GRNs in a continuous manner across cellular trajectories. Hence, you don’t just map GRNs / TF regulators, you can actually infer cell plasticity and predict the future state of a given cell
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Here we developed a new deep learning based GRN inference framework: scDORI. See the thread from @manusaraswat10 for more details but few highlights here
🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktar_lab , @OliverStegle and @MoritzMall groups. Preprint at end🧵👇
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