Moraga Lab
@LabMoraga
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The Moraga group studies cytokines and their central role in immune regulation. We combine protein engineering, structural biology & immunology in our research
University of Dundee
Joined May 2019
RT @BubeckLab: After a hard year, I’m glad to see this finally over the line. A real team effort from @YiboJin @scott_d_gardner @TomasV….
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RT @LabWaggoner: Disease-associated variant in IL6ST gene encoding for gp130 led to increased flexibility including motion within the cytok….
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Excited to share our newest full collaboration with @BubeckLab. We provide structural insights that help explain how mutations in gp130 that do not disrupt cytokine binding cause signaling defects and immunodeficiencies in humans. @UoDCellSigImm.
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RT @hitchcock_lab: 🚨2 Yr Postdoc Available🚨 .Jointly supervised with @scienceadvocacy working on normal and pathological HSCs, cytokines, m….
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RT @biorxivpreprint: Differential functional coupling in Gp130-JAK complexes expands the plasticity of the interleukin-6 signaling axis ht….
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Ever wonder why ancestral cytokine receptors, like Gp130, bind multiple JAKs, and whether the identity of the GP130-JAK complex instructs specific responses? Check our new work, in a full collaboration with the @PiehlerLab, for some answers.
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RT @FEBSJournal: 📜State-of-the-Art📜. Molecular and cellular factors determining the functional pleiotropy of cytokines . 🖋️ By Alison McFa….
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RT @DrJuanLMendoza: So excited for this session, I couldn’t sleep! Cytokines, engineering, structures, and therapies. Not a session to mi….
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RT @c_garbers: Interested in interleukin-6 and how you can therapeutically block its pro-inflammatory activities? See our latest review, ju….
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RT @DrJuanLMendoza: Join us for the ICIS-sponsored and organized session at Immunity 2023! Learn how both academic and industry members of….
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RT @CytokineSociety: Going to AAI? Please join us for the ICIS Guest Symposium "Understanding and Modulating Cytokine Activity through Stru….
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RT @IforRWilliams: NEW for 2023 on the @SciImmunology website is the dedicated CANCER IMMUNOLOGY block. 🔗➡️Scroll d….
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RT @ACIR_org: SPOTLIGHT: After showing that tumor-derived lactic acid limited IL-2 signaling, STAT5 phosphorylation, and antitumor activity….
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RT @chngin_the_wrld: Today's #shoutout to #womeninSTEM goes to SILVIA GAGGERO for her @SciImmunology paper w/ @at_Mitralab showing IL-2 is….
science.org
An engineered pH-selective IL-2 mutein augments cancer immunity in the acidic tumor microenvironment with limited systemic toxicity.
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RT @ScienceMagazine: A new study looks to make IL-2 therapy more effective in tumors, presenting a variant of the cytokine that retains its….
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RT @ScienceMagazine: A new study looks to make IL-2 therapy more effective in tumors, presenting a variant of the cytokine that retains its….
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RT @apoptosislab: Another straightforward reason why the Warburg metabolism causes immune suppression in the TME. IL-2 is inactivated by th….
science.org
An engineered pH-selective IL-2 mutein augments cancer immunity in the acidic tumor microenvironment with limited systemic toxicity.
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RT @SciImmunology: A new study looks to make IL-2 therapy more effective in tumors, presenting a variant of the cytokine that retains its b….
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