Our Disease Mechanisms Focus Issue is out now 📗🪰 Articles in this issue combine fundamental structural insight with mechanistic implications for disease. Read the issue here ➡️ https://t.co/49B2cPFtmR

We are pleased to highlight this new article from our recent Structural Insights into Disease Mechanisms focus issue 🧪🧫 📗 The CRISPR-Cas9 knockout DDC SH-SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a

Honored that our @FEBSJournal paper was spotlighted!🤩🙏 Led by @TalBenZuk this study reveals how a PRKAR1B mutation in patients disrupts PKA regulation, causing NLPD-PKA, a neurodegenerative disease we recently named. Thanks to the patients and our wonderful collaborators

We are pleased to spotlight a new #OA article from our Disease Mechanisms focus issue 🧠 Allosteric modulation of protein kinase A in individuals affected by NLPD-PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed Read the article here ➡️

🔬 The authors assess advances in CX3CL1 research, including its mechanism of action, and explore its implications in physiological and pathological scenarios from the perspective of skeletal muscle function and other key metabolic organs. @FEBSJournal | https://t.co/3afOsBePWQ

Phylogenetic reconciliation provides new insights into the evolutionary diversification of the glutamine synthetase gene family in seed plants https://t.co/z8EQxpiK9u @FEBSJournal

New State-of-the-Art-Review from our recent Structural Insights into Disease Mechanisms focus issue 🪰🧪 📗 In vivo and in silico models of #drosophila for #parkinsonsdisease Read the review #openaccess here ➡️ https://t.co/ZsVWr2vahp

Excited that our work led by the Dere Lab is now published! This study is the first to identify KDM4A as a centrosome protein, revealing its chromatin-independent function in maintaining centrosome integrity and genomic stability. #microscopy @FEBSJournal https://t.co/VGkq6wKX7t

Excellent review in the @FEBSJournal "Emerging roles for integrated stress response signaling in homeostasis" Shyama Nandakumar, Lydia Grmai, Deepika Vasudevan https://t.co/IcVrdLpd62

🩺 Małgorzata Kosla and her husband Piotr established the PACS2 Research Foundation when their daughter was diagnosed with this ultrarare syndrome. In this interview, we discuss the family's journey to obtain a diagnosis, and ongoing projects spearheaded by the Foundation ➡️

Excited to share our new paper“Fractalkine is a key player in skeletal muscle metabolism and pathophysiology” in @FEBSJournal Thanks @GSwalsingh82435 @PunyadharaP @sadayappanlab for contribution. https://t.co/REVhWslhc2 Thanks @DBTIndia @KIITUniversity @achyuta_samanta

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Increased chromatin accessibility underpins senescence https://t.co/fRq1erZk8V @FEBSJournal

Neutron diffraction reveals protonation states in pyridoxal-5′-phosphate-free and glycine external aldimine-bound serine hydroxymethyltransferase https://t.co/JJyM15fVbu @ORNLNeutrons @FEBSJournal

I love stories. Especially the ones with a twist at the tail—or should I say... 3′end? In our latest review, @Erson_BensanLab, @ibrahimozgul_ and I dive deep into the neglected isoforms in cancer. @FEBSJournal @FEBS_Letters

Excited to share our new paper in @FEBSJournal Our finding describes the ambiguity of Histidiol dehydrogenase activity in Pseudomonas. A novel Zn binding site and an evolved architecture of the active site are demonstrated in the structure. @CSIR_IND https://t.co/ISj73tLjOM