PiehlerLab
@PiehlerLab
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Excited about proteins, membranes, signaling and microscopes
Joined May 2021
Professorship at UOS in an excellent research environment: SFB 1557 https://t.co/VUBrVaetAQ, RTG 2900 https://t.co/88bGYpsGga Less than a week left to apply: https://t.co/7DhlReedez
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Terrific to write this preview in @CellCellPress with Samantha Joubran on an outstanding paper describing the structure of the THPO-MPL complex and its role in hematopoiesis from the Garcia lab: https://t.co/98zC8PmCNK
https://t.co/xo3CcANEzO
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Now online! Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis
cell.com
The thrombopoietin-MPL axis plays essential roles in hematopoietic stem cell biology and platelet production. Cryo-EM structure of the dimeric thrombopoietin-MPL receptor complex enabled design of...
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Our RTG "nanomaterials@biomembranes" made it into the "final 11" - many thanks to the terrific team!
11 neue Graduiertenkollegs #GRK erhalten #DFG-Förderung von rd. 76 Mio. € für Förderperiode ab Herbst 2023. Die Themen reichen von der Entstehungsgeschichte des Universums über die Qualität in der #Gesundheitsforschung bis zur Forschung an Nukleinsäuren.
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We, at the Weizmann Institute of Science, are ashamed of, and dismayed by the Israeli government, who is threatening to crush all the conditions for the existence of a healthy civil society, and to act contrary to the law and the court’s order. (1/6)
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🍰 Leptin is a hormone that promotes satiety. But how does it give the 'I'm full' signal? Alexandra Tsirigotaki, Kenneth Verstraete, Savvas Savvides, and colleagues @InflamResCen present the 3D structure of leptin as it binds to its https://t.co/2HI6CNoO1I
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Leptin receptor assembles into trimers: amazing structural work from the @SavvidesLab! https://t.co/kBw48mfsIv
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reHaloTag labeling: final version is now online: https://t.co/obii9agbFu: long-lived, works with traditional HTL dyes and is ideal for single molecule tracking! Happy to share the clones, soon available from Addgene.
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🔬 Drs. @Steven_C_Wilson and Nathanael Caveney (@CaveneyNA) at @StanfordMed used #cryoEM, single-molecule imaging, and cell-based signaling approaches to explore the structural basis for IL-17 family signaling. 📝 @Nature | https://t.co/nL9wpph2rz 💬 | https://t.co/QOZU6oMTI0
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Proud to share the structure of HOPS, a spectacular tethering and fusion complex! Super work by @DmitryShvarev and tw-less Jannis Schoppe and Caroline König. Great collaboration with @UngermannLab and first structure from our Glacios Elenor! https://t.co/nNM7xOoKkx
#cryoEM #UOS
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Finally, the exciting lattice light sheet microscopy results from the collaboration with the Reth lab. Congratulations to Deniz, Bugra and Michael: amazing imaging and analysis! https://t.co/JsCCN4QGiP
biorxiv.org
B lymphocytes recognize bacterial or viral antigens via different classes of the B cell antigen receptor (BCR). Protrusive structures termed microvilli cover lymphocyte surfaces and are thought to...
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A tremendous fight from Christoph - first with the experiments, then with the reviewers. Congratulations!
"Diffraction-Unlimited Photomanipulation at the Plasma Membrane via Specifically Targeted Upconversion Nanoparticles" - collaborative article by researchers of @UniOsnabrueck #CellNanOs & @UniJena
https://t.co/woSDDBIf77 /#NLAR
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Many thanks to @barisch_c, Michael Hensel and Rainer Kurre for another exciting imaging workshop! Beautiful electron microscopy and CLEM from Dominique Soldati-Favre, @EnningaL, and Kay Grünewald - and the cool CLEIM work from Pierre Santucci.
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