Kepecs Lab
@KepecsLab
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1/ Why do late-stage cancer patients lose motivation & sink into apathy?.š„Our new Science paper shows cancer activates a cytokine-sensing brain circuit to lower motivation.Great work by Aelita Zhu @sarahstarosta @Pignatelli_Lab @JanowitzTobias &team!š§µ.š
science.org
Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical...
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#ChatGPT5 is a letdown, not because it's not AGI, but because it's slow and then shy about discussing molecular biology "for safety reasons" Just canceled; Gemini's looking better.
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Wow, this is truly exciting! Congrats to @KevinJTraceyMD and the whole team. .
Congratulations to everyone at Setpoint Medical, present and past, who worked for 18 years to bring a brand new idea for the first time into a clinical reality. This begins a new era for millions of patients needing new options.
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RT @manorlaboratory: Grateful to @megtirrell and @CNN for covering this story. My NIH grant to study hearing loss was abruptly canceled, thā¦.
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RT @kwanalexc: We worked so well as a team for the #GRCPsychedelics @VVyazovskiy @MelissaHerman4 @ViditaVaidya . and congrats to @TheBorisLā¦.
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Reducing animal use is a worthy goal but mechanistic discovery, the engine of biomedical progress, still requires animal models. Translation is vital and challenging and could be improved with these initiatives. Just donāt conflate the two.
While Iām a big fan of new technologies that help us study human biologyā¦thereās still no replacement for animal research! I wrote an article outlining this in @GENbio .
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Tbh, iāve been wary of scale-free avalanches etc bc 1/f noise often felt like self-organization trivia with no link to computation or behavior. This article starts to close the gap, casting criticality as a homeostatic target for dynamics. Convincing, must read & discuss!.
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Is criticality the common set-point of brain function? Must read Viewpoint by @KeithHengen & Woodrow Shew in @NeuronCellPress marshals a meta-analysis &.evidence that our brains aim for the brink of phase transition ācriticalityā as a built-in set-point for flexible computation.
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RT @kwanalexc: Canāt believe #GRCPsychedelics is happening in two weeks!. We reached capacity attendance ā sorry we could not accommodate eā¦.
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RT @dr_alexharris: This chart made by Peter Gleick shows the proposed cuts to science graphically. This is bad for America. Please ask Coā¦.
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RT @jonykipnis: The most vocal āprotector of minoritiesā, sitting on billions of private dollars, is the first to retreat because of the riā¦.
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Why does CAR T-cell therapy cause "brain fog"? .In a landmark study @michelle_monje et al. show white-matter inflammation drives cognitive deficits. Blocking these, either resetting microglia or dialing back their chemokine response restored myelin & rescued attention+memory!.
CAR T cell therapy can be life-saving, but like many other cancer therapies, can cause long-term ābrain fogā. We discovered the cellular dysregulation underpinning this and a strategy to rescue the cellular and cognitive dysfunction in mice.
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Meet the Area Postrema!.
Cancer muscle wasting-associated apathy is result of tumour-induced inflammation & brain circuitry interaction. š· Xiaoyue Aelita Zhu & Sarah Starosta et al @KepecsLab @Pignatelli_Lab @JanowitzTobias.@WashUMedNeuro in @ScienceMagazine .ā”ļø + @rooph
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RT @BPoD_s: Cancer muscle wasting-associated apathy is result of tumour-induced inflammation & brain circuitry interaction. š· Xiaoyue Aelitā¦.
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Beautiful study by my colleagues showing the synaptic mechanisms for ketamine "anti-anhedonic" effects. @FedeLucantonio and @Pignatelli_Lab.
Very proud to see this beautiful artwork, highlighting @FedeLucantonio's paper, made by our talented former lab member @qwinkledink on the cover of @NeuroCellPress ! š¤© Aleesha is now launching her career as a digital illustrator please, check her work!.
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We need bodyoids with brainoids inside!.
Controversial opinion. but organoids are not brains and if you want to understand cognition, you canāt study it in a dish.
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RT @_cingraham: Most people donāt understand how *new* most cancer treatments are. The treatment that cured my lymphoma was developed whenā¦.
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RT @SashaGusevPosts: Nobel laureate Bill Kaelin on Killing the Science Golden Goose. "This is especially worrisome because becoming a sciā¦.
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RT @WashUMedNeuro: Congrats to Hysell Oviedo, PhD, who has been installed as the Roger M. Perlmutter Career Development Assistant Professorā¦.
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RT @AToliasLab: After 7 years, thrilled to finally share our #MICrONS functional connectomics results!. We recorded activity from ~75K neurā¦.
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