ACTA2 gene mutation causes childhood-onset stroke disorder via smooth muscle cell dysfunction => blocked arteries. 📷 Anita Kaw & Suravi Majumder et al @McGovernMed in @NatureComms .➡️ with @AntDLewis

Model Jaw Drops: Jaw bone organoids created from human pluripotent stem cells provide 3D means to study jaw development & disease. 📷 Souta Motoike et al, Center for iPS Cell Research and Application, Kyoto University in @natBME .➡️

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Split Decision: Insight into the apparent paradox that Wnt/β-catenin pathway can induce stem cell differentiation or pluripotency. 📷 Kevin R. Yi et al @MinervaBio in @PLOSONE .➡️ with @AntDLewis

Organ Synthesiser: A mouse embryo model capable of progressing to organogenesis – created using es cells coaxed to embryo founder cells. 📷 Huanhuan Li, Wei Guan, Jiahui Huang et al Guangzhou International Bio Island in @CellCellPress .➡️

Following the behaviour of food-additive titanium oxide at destinations in the human body. 📷 John W. Wills et al @CamVetSchool in @NatureComms .➡️ with @AntDLewis

How the functional architecture of the zebrafish heart is shaped during development . 📹@tobyandrews et al @_Priya_R lab @TheCrick in @Dev_Cell .➡️

The brain's emotional pain pathway identified – new targets for developing pain medication. 📷 Sukjae J. Kang et al @salkinstitute in @PNASNews .➡️ with @rooph

Cytoskeletal microtubules bring myofibrils within muscle cells into close contact with mitochondria to provide energy for muscle building. 📷 Jerome Avellaneda et al @uniamu in @Dev_Cell .➡️

Blood Running Cold: Cryo-scanning electron microcopy of haematology samples. 📷 Irina Davidovich, Carina Levin & Yeshayahu Talmon @TechnionLive in @JofMicroscopy .➡️ with Lux Fatimathas

Make Some Peroxisomes! Provision of the right number of organelles called peroxisomes needed by a cell is regulated by PKC enzyme . Image made with @LeicaMicro microscopy. 📷 Anya Borisyuk et al @EPFL_en & @unisouthampton in @JCellBiol .➡️

Peripheral Vision: Entire peripheral nervous system of a mouse fluorescently imaged for the first time. 📹 Mei-Yu Shi, Yuchen Yao & Miao Wang et al, University of Science & Technology of China in @CellCellPress .➡️ with @rooph

Human foetal kidney-derived organoids grown for prolonged periods as faithful models of kidney development show Notch is developmental regulator. 📷 Michael Namestnikov et al Sheba Medical Center, Tel HaShomer, Israel in @embojournal .➡️

Look Again: A dense labelling system for more accurate 3D alignment after repeated tissue expansion & imaging. 📷 Hyunwoo Kim & Joon-Goon Kim et al @kaistpr in @PLOSBiology . ➡️ with @AntDLewis

Advanced machine learning + classical image analysis pipeline for gross & cellular high-throughput 3D screening of organoids. 📹 Hui Ting Ong & Esra Karatas et al @NUSingapore in @naturemethods .➡️

How streptococci bacteria infect the brain to cause meningitis revealed in zebrafish. 📹Sumedha Ravishankar et al @ucsdbiosciences in @PLOSBiology .➡️ with @AntDLewis

Pre-cancer cells secrete Netrin 1 that promotes sprouting & branching of nerve projections providing conditions ripe for cancer progression. 📷 Hiba Haidar et al @uniamu in @NatureComms .➡️

Insights into how TB bugs can evade vaccine-trained immunity. 📷 Kimra S. James et al @UUtah in @Nature_NPJ Vaccines .➡️ with @rooph

Epithelium repair is promoted by bursts of hydrogen peroxide from DUOX2 protein. 📷Maurice O’Mara, Suisheng Zhang & Ulla G. Knaus.@UCD_Conway in @NatureComms .➡️

Zelda's Link: The role of gene activity-switching transcription factor Zelda in controlling tissue regeneration. 📷 Anish Bose et al @UofIllinois in @ScienceAdvances .➡️ with @DrJohnAnkers

Cell migration–inducing protein (CMIP) controls contractility of blood vessel wall cells to maintain blood pressure. 📷 Ze Yuan et al, Tianjin Medical University, China.in @CircRes .➡️