Biomedical Picture of the Day BPoD
@BPoD_s
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Vibrant, daily intriguing images from global research. Supported by @LeicaMicro & @BiochemOxford. https://t.co/qQEfTVxfGb LINKS TO THE PAPER on https://t.co/j4sPLYzIIg
Oxford
Joined November 2011
Ion channel molecule PIEZO2's role in cardiovascular development revealed. Loss causes misshape & aberrant branching. 📷 Mireia Pampols-Perez et al Max Delbrück Center for Molecular Medicine in the Helmholtz Association in @NatureCVR .➡️
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Prostaglandin E2 promotes muscle regeneration in aged mice. 📷 Yu Xin Wang, @adepalla & Andrew T.V. Ho et al @StanfordMed in @CellStemCell .➡️ with @rooph
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Achieving super-resolution microscopy for deep tissue imaging by cost-effective adaptation of two-photon laser-scanning microscopes. 📹 Patrick Byers et al Multiphoton Imaging Lab, Munich University of Applied Sciences in @NatureComms .➡️
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Ticked Off: A gene called TNT underlies mitochondria-dependent gut muscle growth as ticks feed – a threat-limiting target. 📷 Zhengwei Zhong & Kun Wang et al @FudanUni in @CellReports .➡️ with @DrJohnAnkers
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Normal blood progenitors in the bone marrow polarise towards the stromal niche, but acute myeloid leukaemia cells, a form of BM cancer don't. 📷 @el_Khansa_S et al Thery Lab, Université Paris Cité in @emboreports .➡️
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Small But Mighty: Single-domain antibodies (nanobodies) derived from llamas against SARS-CoV spike protein are potent & neutralizing. 📷 Sieglinde De Cae et al VIB, Ghent, Belgium in @NatureComms .➡️ with @rooph
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See Organoids Organise: Tracking brain organoid development from fluorescent human induced pluripotent stem cells over weeks using live light-sheet microscopy. 📹 Akanksha Jain, Gilles Gut et al Treutlein lab @ETH_BSSE in @NatureComms .➡️
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Stain Removal: Biopsy details revealed using label/stain-free indicators detected by a multimodal imaging approach. 📷 Anthony A. Fung et al @ucsdbe in @NatureComms .➡️ with @AntDLewis
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Deadly Ascent: Breast cancer cells can spread by migrating along the outside (!) of blood vessels to the brain facilitated by Reelin-LRP8-CDC42 axis. 📷 Haofeng Huang, Min Zhang & Enyu Huang et al Guangdong Medical University in @EmboMolMed .➡️
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The brain keeps erroneous connections (green) separate from accurate synapses (purple) by forming a synaptically isolated subcircuit . 📹 Sean McCracken et al @washumedicine in @eLife .➡️ with @DrJohnAnkers
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Blockable offence – basal cell carcinoma's low response to immunotherapy is due to low HLA class I attenuated by epigenetic regulator FOXC1. 📷 Tomonori Oka et al @MGHCancerCenter in @CellReports .➡️
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Hostile Merger: HIV-infected T cells fuse with macrophages creating large cells where the virus thrives. Image made with @LeicaMicro microscopy .📷 Marie Woottum et al Institut Cochin, Paris in @PLOSPathogens .➡️with @AntDLewis
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Ideal Home: Location and the nature of the niche haematopoietic (blood-cell forming) stem cells occupy in the spleen identified. 📷Shubham Haribhau Mehatre et al @tvmiiser in @embojournal .➡️
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How p97/VCP enzyme disposes of harmful aggresome protein clumps – clues for tackling neurodegenerative disease . 📷 Maria Körner & Paul Müller et al, @Uni_WUE in @NatureComms .➡️ with @rooph
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Inducible genetic engineering tools in mouse embryonic stem cells to aid synthetic developmental biology research. 📷 @ssssoliman et al @UCSF in @Dev_journal .➡️
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Rete Petite: 'Forgotten' ovarian structure has a role in maintaining ideal ovary conditions.📹 Dilara Anbarci et al @DukeHealth in @eLife .➡️ with @DrJohnAnkers
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Xenopus frog study examines gene variant found in a child with mirror-image organ placement & other developmental defects, reveals role of Wnt11. 📷 Henrike Berns et al, Miriam Schmidts @WalentekLab University of Freiburg in & on cover of @DMM_Journal .➡️
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Meclonazepam - a new therapy for parasitic flatworm infection schistosomiasis . 📷 Clair R. Henthorn & Paul McCusker et al, @UWMadison in @PLOSNTDs .➡️ with @AntDLewis
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Flu virus spreads via tunnelling tubes it induces between cells: tube formation correlates with onset of apoptosis. 📷 @DanielWeirIAV et al @CVRHutchinson lab .@UofGlasgow in @PLOSPathogens .➡️
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Super resolution microscopy reveals details differentiating biocompatible polymers. 📷 Dongmin Lee, Uidon Jeong & Doory Kim @LABKIM238611 Hanyang University, Seoul, Republic of Korea in @ScienceAdvances .➡️ with @DrJohnAnkers
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