Uri Manor 💔
@manorlaboratory
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Ass. Prof & Director UCSD Goeddel Family Technology Sandbox; CZI Imaging Scientist; Hard-of-hearing; Follows≠endorse; we ❤️ organelles/actin/cochlea/neurons
La Jolla, San Diego
Joined December 2014
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A much too flattering profile of yours truly. A testament to Vivien’s writing skills to actually make it sounds like I (1) am interesting and (2) know what i’m doing 🤣
“The whole concept of tools making life a better place is a
deep part of me,” says Uri Manor
@manorlaboratory
@salkinstitute
in a profile by
@metricausa
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Just a little reminder that this thing called The Vault is a real thing that exists in nearly all eukaryotic cells
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ICYMI: Cancer cells suck mitochondria out of immune cells via tunneling nanotubes. Such a visceral illustration of the evil that is cancer!
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Just received a rejection letter for a faculty application I submitted in 2015. Please allow me some time to reflect and recover from this devastating rejection. I apologize to all of my friends and family for this disappointing failure.
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This may be one of the most exciting and comprehensive reviews on mitochondria I've seen in a long, long time.
"Mitochondrial signal transduction", Picard and Shirihai
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It is impossible to put into words just how devastatingly tragic this is. Swati was a truly unique combination of brilliance, kindness, and generosity. Her absence is tragic enough. But to add to that her 11-mo son who will never get to grow up knowing her simply destroys me.
Our deepest condolences to the family, friends and coworkers of Swati Tyagi, PhD
@swatstyagi
. Swati, a postdoctoral researcher and rising star in the Hetzer lab, was tragically killed when a car struck her from behind while she was riding her bike.
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This is absolutely bonkers and so so so important for every animal researcher to keep in mind
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Seems like as good a time as any to share this GPT-4 image I generated using a grant abstract as the prompt. Maybe we’ll put it in paper!
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I’m willing to wager >50% of strong female STEM faculty candidates were rejected because weak men couldn’t imagine those women being as successful as male candidates who were weaker.
Our female colleagues didn’t make it because of bias; they made it *in spite of* bias.
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As of July 1st I have moved over to
@ucsdbiosciences
(and an
@HDSIUCSD
affiliate) as a tenure-track Assistant Professor and I will also be Director of the new Technology Sandbox - I am so so SO excited!!!
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Got our first big-boy NIH score: 17 (4%-ile). That’s...fundable, right?
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I love that to many (most?) labs, one of the major foci of our lab (actin cytoskeleton) is a “housekeeping gene” used as a loading control. Even better that it varies by 6x over time LOL. Thanks to
@PLURplus
for letting me share this
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If you'd like to hear the whole story as to how we got from the movie on the left to the movie on the right, come join me for a "tweetorial" starting now!
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My very first senior author manuscript. Equally important: My very first preprint! So stoked to finally be a direct participant in this long overdue process for accelerating biology.
Actin chromobody imaging reveals sub-organellar actin dynamics
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Our preprint hit 677 downloads in just 24 hours. A friend pointed out "deep learning" is a huge buzzword so of course it did. Which got me thinking - what would get max downloads? 1st try:
"Deep learning based CRISPR nanotechnology modulates phase separation in stem cells"
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Apparently lab mice breed way more in spring than in winter.
My question is: Since light/climate is controlled throughout the year, how do these mice know what time of year it is? Does anyone know?
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A lot going on these days, but as a start, I started a Twitch streaming channel (ManorLab). Once we get the kinks sorted out, I will start announcing on Twitter when there will be live streaming sessions, ranging from confocal to EM to image analysis training sessions
Salk’s Uri Manor to receive over $690,000 from Chan Zuckerberg Initiative to develop new open-source imaging tools and data sets while expanding educational outreach
@manorlaboratory
via
@salkinstitute
@ChanZuckerberg
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We had an absolutely insane sunset
@salkinstitute
today. Clouds rolling low over the ocean created beautiful textures I’ve never seen before.
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OMG OMG OMG it finally came in! And not a cent was shaved off our requested budget!!! I cannot express my gratitude enough to the reviewers and also the
@NIDCD
council for their support for my very first R01. Now let’s get to work!!!
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I pretty regularly share the super plots paper by
@samjlord
and
@MullinsLab
with new core users, lab members, and collaborators. It has one of my favorite figures of all time.
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We *finally* made organelle-targeted actin probes () available on
@Addgene
! I hope actin and organelle aficionados find these useful. Many thanks to
@cziscience
for supporting our open imaging science and tool-sharing efforts!
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Finally got an R01 score I can be proud of! Hopefully no surprises down the road and this gets funded.
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Senior PI giving comments on a figure made by an expert collaborator from a completely different field
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Y'all need more cochlea in your timelines. I typically favor stereocilia, but we have been spending lots of effort improving our imaging of these beautiful synaptic structures. This was captured and rendered using the
@OxInst
BC43 then rendered with
@ImarisSoftware
.
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someone wrote a yelp review for our lab building address and i cannot breathe
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@beatascienceart
wins 1st price for today’s
#CellBio2022
poster session. Absolutely stunning science art!
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so excited about the upcoming holiday break when everyone leaves town and I can have 3 or 4 microscopes all to myself
omg what is wrong with me
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Just a subtle reminder that I have a new email address so please contact me there!
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my 3yo’s school is closed until 4/20.
good part: my wife is a teacher there so she’ll be home too.
bad part: my wife is supposed to teach online during that time. 3yo will make that very difficult.
best part: she teaches *kindergarten*. how do you teach *6yo kids* online???
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gearing up for a night of imaging. it’s been way too long since i’ve been on campus to see a sunset or to see a sample at the scope.
#soblessed
#gratitude
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w00t!!! the new, vastly improved version is now available on
@naturemethods
here. a tweetorial delineating the improvements is forthcoming.
My very first senior author manuscript. Equally important: My very first preprint! So stoked to finally be a direct participant in this long overdue process for accelerating biology.
Actin chromobody imaging reveals sub-organellar actin dynamics
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Editing is 85% shortening sentences.
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We are officially in business wrt viral transduction of GFP-tagged proteins in cochlear hair cells.
It’s going to be a great year.
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Our new toy!!! So excited to bridge transcriptomics with imaging ❤️
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Just learned I got new funding to explore a completely new, but thrilling research direction that I cannot be more excited about!!! Two years ago I wasn't even aware of this molecular pathway and now I've got money to study it with the imaging tools we built.
#livingthedream
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Very cool:
Light Activated BioID (LAB): an optically activated proximity labeling system to study protein-protein interactions. | bioRxiv
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Today my wife donated this breast milk to fragile babies at
@UCSDHealth
hospital. Each bag is ~25 lbs!!!
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As a PI I swear that 90% of my time at the bench is spent trying to figure out where my people put everything
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Running a lab really feels like a rollercoaster between being completely on top of the world vs. facing impending doom, all hinging on whether grants get funded or not. This "winner takes all" tournament system has got to be reformed, IMO, especially as resources get tighter.
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Alright tweeps. Which one do you like better? Every time I think I've decided, I look again and change my mind.
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omg it’s finally out! so very grateful to have worked with the best team i could ever dream of:
@linjing_fang
@jeremyphoward
@sammy_wn
@GulcinPekkurnaz
and many others on/off twitter i couldn’t tag for some reason
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beautiful and important new paper by
@aaandmoore
, one of the best cell biologists and microscopists i know
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Just discovered this absolutely critical manuscript. Perhaps the most important manuscript ever written.
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This may be the single most wonderful visualization of real biological imaging data I have ever seen in my life
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Somehow just now learned about this amazing overview snapshot of the incredible diversity of mitochondrial structure in Cell by Walter Neupert:
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wooooooooooow ok this may be one of the coolest live cell imaging videos i’ve ever seen
Reaction diffusion observed on a fertilized egg cell.
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So proud of our new lab group photo! Sucks that it will probably be outdated soon enough (have I mentioned that we are hiring?!)
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I love how it's so painful to proofread something before submission but then after submitting it you can read and detect every single typo and error with laser focus
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OMG mitochondria FACS sorting!?!?!
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Single timepoint snapshots also don’t give them the recognition they deserve - look at those dynamics!
Textbook cartoons rarely give the powerhouses of the cell the recognition they deserve
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Small reminder that good things can happen. NOA should arrive in the next week or two and I could not be more excited!
Also just got news that a collaborative Alzheimer’s supplement is going to be funded. When it “rains” it pours!
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look look ma i’m in the newspaper!
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Just now updated with the percentile. This seems...promising?
Finally got an R01 score I can be proud of! Hopefully no surprises down the road and this gets funded.
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t-3 hours to my promotion seminar i received an email notification that a paper was accepted for publication - huzzah!!!
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I am predicting Biorender will amend their terms in the next few days. If you cannot preprint to
@biorxivpreprint
anything with Biorender figures in it, EVEN AFTER PAYING, I cannot see how they’ll ever stay in use, let alone in business.
@baym
@wc_ratcliff
@BioRender
@cshperspectives
I have explicit confirmation from Biorender that CC BY was not okay without explicit written permission obtained by writing to a specific non public email address. As of November 2023 no CC BY at all possible anymore.
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Stunning work clarifying how ER-mito contacts are organized by
@cjobara
and
@AbellJonny
and
@aaandmoore
in the
@JLS_Lab
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please RT: i have two open positions for inner ear research projects - one postdoc and one lab manager/tech. if you know anyone with experience with hearing research please send them my way! we will be doing gene therapy, fluorescence and EM imaging (including cryoEM), and more!
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Awesome tool everyone should use - simulates colorblindness to check your figures and make sure they are color blind friendly
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I am way too proud of the fact that I got away with making this my student ID photo (I think the woman making the ID cards that day was pretty hung over and didn't care to argue with me)
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In awe of the talent in my lab. The amazing
@popelectrical
made this Alice in Wonderland themed representation of Manor Lab research for an upcoming
@salkinstitute
art contest. Tons of tiny details and metaphors in here. Can’t wait to put this up in the lab.
#livingthedream
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Found this on my office door today. My people understand me so well.
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Absolutely insane to exclude David Baker from this award IMO
Great to see the people at DeepMind behind AlphaFold get the recognition of a Lasker Award! But award committees, don’t forget that David Baker at UW has been pushing this field forward for years, all in an open academic setting.
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I don’t know how it happened, but today I got notice of award from
@NSF
for a huge (24 PI!) NeuroNex grant probing synaptic weights with advanced imaging approaches with an insanely amazing group of scientists including the likes of
@BWJones
@stardazed0
and many others.
#blessed
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Watching one of my favorite people and scientists
@cjobara
from
@JLS_Lab
knock it out of the park with his beautiful work on ER-mito contact dynamics
#CellBio2022
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omg it’s a nuclear pore
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i really really really REALLY love my 3yo so damn much and this time with her is truly a blessing that i may never get again
but if she doesn’t make an imaginary friend soon i may go insane
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Interesting looking new paper investigating the relationship between mitochondrial morphology and ER-mito calcium exchange
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Just got some more amazing grant news and I couldn’t be happier. Also learned one of my favorite junior scientists got an amazing award (not announced yet) and sometimes it is hard to remain cynical. Failures greatly exceed the success rates, so gotta celebrate when it happens 🎉
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13 years ago today my Abba died. I cannot enjoy anything in life 100% because every single joy or success is tempered by the fact I cannot share it with him.
But still I work hard everyday to try to do something that would’ve made him proud. It makes me feel better.
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I love this way too much
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Lots of great news today. First we found out our Suborganellar Actin Chromobody paper was accepted to my favorite journal (preprint here: )
Then I learned our insane DL-based Kavli Innovation proposal was accepted (announcement: )
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Absolutely stunning segmentation and tracking performance here, and without any deep learning! Can't stop staring at these movies :)
So excited to share our work on tracking mitochondria and correlating metabolic activity :)
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I forgot about this! 10 years later my (now 18yo!) daughter came out & introduced me to her lovely girlfriend. My older brother was also gay & thankfully my parents showed us way back in the 80’s how truly stupid & regressive is homophobia. We’ve come far but still far to go 🏳️🌈
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Our beautiful baby is ready!!! What should we name her?
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Look at this amazing segmentation of mitochondria in skeletal muscle from a serial blockface SEM dataset. Who knew they are all interconnected like that? This is from our 3DEM guru Sammy Weiser Novak - one of the most talented people I've ever mentored.
#SoLucky
#mitochondria
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@dmbtrivia2
@magneticksara
@salkinstitute
i’m going to give a full response asap. but quickly for the record:
1) the (relatively) small amount of spike protein produced by the mRNA vaccine would not be nearly enough to do any damage
2) i happily got the mRNA vaccine, FWIW
3) i encourage everyone to get it
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I got to witness some amazing bioluminescence tonight. Reminds me so much of live videos of lamellipodia (some examples from the inestimable
@MAG2ART
in the thread below)
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Job alert (please RT)! I am honored to be working closely with
@DmitryLyumkis
on this super exciting project at the cutting edge of microscopy and viral cell biology. Please go to the link here if you're interested, and please spread the word!
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How many of y’all knew 95% of the serotonin in our bodies is in platelets, and 50% of platelets are in our lungs?!?
I’m still doing lots of reading but there is an incredibly compelling body of work indicating serotonin toxicity and platelets underlying severe COVID-19.
"Platelet-derived serotonin links vascular disease and tissue fibrosis"
5-HT2B activation by serotonin released from activated platelets promotes tissue fibrosis.
Blocking 5-HT2B prevents the effect in vivo.
Cyproheptadine blocks 5-HT2B
@farid__jalali
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Today my family staged an intervention regarding my peanut butter subscription at Amazon
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We are hiring a new Light Microscopy Specialist to join our growing team. Please spread the word!
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Apparently an
@eLife
editor removed an acknowledgement for our core funding from a manuscript. Apparently because they only parse out funding by investigator. Maybe eLife and other journals need a specific spot for core funding to make it easier to acknowledge these resources???
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