Can’t believe #GRCPsychedelics is happening in two weeks!. We reached capacity attendance – sorry we could not accommodate everyone. We look forward to seeing many of you at the meeting. w/ @VVyazovskiy @ViditaVaidya @MelissaHerman4

RT @JRichardPhD: Looking forward to next week's Gordon Research Conference. This will be my first time presenting an emerging transdiagnost….

RT @Xylo_Bio: 🧠 We're excited to attend the Gordon Research Conference on the Neurobiology of Psychedelics next week in RI!. We'll be prese….

RT @PraachiTiwari: Excited for this conference!!!! .#GRCPsychedelics .If you are coming, please drop by the poster and say hi. Also lookin….

RT @JHPsychedelics: Thrilled to connect at the Neurobiology of Psychedelics Gordon Research Conference (@GordonConf) next week! CPCR resear….

@OneMindOrg @ACSPublications @ACSChemNeurosci @Psyched_Alpha @mindmedco @Engrail_Tx @JHPsychedelics @SinaiBrain @Xylo_Bio @PsyPharmacists @CoherentCorp @GilgameshRX @UMconsciousness @UWTCRPS @RachelYehuda @ExistWell @zenbrainest @lab_nichols @akaye @KateNautiyal @ArgelAV @NUro_science @LabWalsh @ClaireFoldi @bita137 @KepecsLab @DR_WANG_SIBCB @WackerLab @john_mccorvy @LinTianPhD @GitteKnudsen2 @T___Kawashima @omarahmedlab @MayoOnTheBrain @DavidErritzoe @CRodriguezMDPhD @FredBarrettPhD @N_Gukasyan @NeuroBanks @amykooz @TheBorisLab and others I may have missed.

@OneMindOrg @ACSPublications @ACSChemNeurosci @Psyched_Alpha @mindmedco @Engrail_Tx @JHPsychedelics @SinaiBrain @Xylo_Bio @PsyPharmacists @CoherentCorp @GilgameshRX @UMconsciousness @UWTCRPS Great lineup of speakers from preclinical to clinical, drug discovery to plasticity, and animals to human research. 🔥. @RachelYehuda @ExistWell @zenbrainest @lab_nichols @akaye @KateNautiyal @ArgelAV @NUro_science @LabWalsh @ClaireFoldi @bita137 @KepecsLab @DR_WANG_SIBCB . .

Big thank you to contributors for supporting speakers and early-career travel awards. 🙏. @OneMindOrg @ACSPublications @ACSChemNeurosci @Psyched_Alpha @mindmedco @Engrail_Tx @JHPsychedelics @SinaiBrain @Xylo_Bio @PsyPharmacists @CoherentCorp @GilgameshRX @UMconsciousness @UWTCRPS

This work was spearheaded by PhD student Hao Wu. The #SCN2A community is incredible. We got interested after first hearing about the gene at the @SimonsFdn Investigator Meeting. Then Hao attended the @FamilieSCN2A #SCN2Aconference, which motivated us to pursue the study. 🙌.

During the adaptive matching pennies task, dendrites of IT pyramidal neurons have reward- and strategy-related signals, but were lost in Scn2a+/- mice, suggesting a potential dendritic basis for their inflexible decision-making.

As an aside: we think this behavioral paradigm is super cool, because we can program the computer to pursue other strategies too… for example another easier "alternate" strategy, and the mouse would adapt differently (!!).

Control mice would adjust to the competitive pressure, where Scn2a+/- mice showed cognitive rigidity and were unable to adapt.

Instead, we had mice play a matching pennies game with the computer. The new twist is that the computer changes strategies during a session – starting off with a strong predictive strategy, then mid-way switch to an easier win-stay lose-switch strategy that the mouse may exploit.

What does this mean for behavior?.It is tricky to find an appropriate behavioral task to evaluate autism mouse models. Previously a study with the Bender lab shows that these Scn2a+/- mice were surprisingly “normal” in a two-armed bandit task.

In Scn2a+/- mice, coupling between apical and proximal dendritic compartments were disrupted, indicating impaired signal propagation in the dendrites.

We used two-photon microscopy to visualize dendritic calcium transients. Using an electrically tunable lens, we rapidly scan different compartments of the dendritic tree in individual PT or IT pyramidal neurons in the medial frontal cortex.

SCN2A is a top risk gene for autism. But how does losing one copy of it affect dendritic function during flexible decision-making? 🧬🐭🧠🧪. Our study in preprint @biorxivpreprint - Supported by a @SimonsFdn SFARI Pilot Award 🙌.#SCN2A #cureSCN2A.

RT @Psyched_Alpha: Compass Pathways’ Psilocybin Clears First Phase 3 Hurdle. “Rest assured, we’ve got something pretty special here”, $CMPS….

RT @JSheltzer: Many incredible biomedical scientists have left academia for biotech/pharma. While also noting many caveats, I want to shar….

RT @realJoshSiegel: This extraordinary psychedelic precision functional mapping dataset is now fully/freely available to all!. All the info….