Can’t believe #GRCPsychedelics is happening in two weeks!. We reached capacity attendance – sorry we could not accommodate everyone. We look forward to seeing many of you at the meeting. w/ @VVyazovskiy @ViditaVaidya @MelissaHerman4

RT @VeronicaChelu: Excited to attend Neurobiology of Psychedelics GRC this week! Looking forward to deep dives into the mechanism of action….

RT @yonicoud: At #GRCPsychedelics ? .Don’t miss Daria Ricci’s (@daria__ri) poster (#29) tomorrow and Thursday! She’s a talented PhD student….

Thank you @NIMHgov @NIDAnews and #BrainInitiative for an informal panel at the #GRCPsychedelics to answer questions regarding grant funding. 🙏

Poster session in full swing. Lots of exciting unpublished work. #GRCPsychedelics

Good morning! An excellent panel today on the evolving theory for explaining psychedelic drug action #GRCPsychedelics

RT @BuzziBelle: Excited to be attending #GRCPsychedelics ! I’m presenting a poster Monday/Tuesday. Feel free to grab a business card from m….

RT @akaye: So excited to participate in this collection of scientists across the translational spectrum developing new treatments #GRCPsych….

RT @ClaireFoldi: We have (sort of) recovered from the jet lag & are now en route to the GRC #psychedelics conference!! See y’all soon 🤗 @Ky….

RT @JRichardPhD: Looking forward to next week's Gordon Research Conference. This will be my first time presenting an emerging transdiagnost….

RT @Xylo_Bio: 🧠 We're excited to attend the Gordon Research Conference on the Neurobiology of Psychedelics next week in RI!. We'll be prese….

RT @PraachiTiwari: Excited for this conference!!!! .#GRCPsychedelics .If you are coming, please drop by the poster and say hi. Also lookin….

RT @JHPsychedelics: Thrilled to connect at the Neurobiology of Psychedelics Gordon Research Conference (@GordonConf) next week! CPCR resear….

@OneMindOrg @ACSPublications @ACSChemNeurosci @Psyched_Alpha @mindmedco @Engrail_Tx @JHPsychedelics @SinaiBrain @Xylo_Bio @PsyPharmacists @CoherentCorp @GilgameshRX @UMconsciousness @UWTCRPS @RachelYehuda @ExistWell @zenbrainest @lab_nichols @akaye @KateNautiyal @ArgelAV @NUro_science @LabWalsh @ClaireFoldi @bita137 @KepecsLab @DR_WANG_SIBCB @WackerLab @john_mccorvy @LinTianPhD @GitteKnudsen2 @T___Kawashima @omarahmedlab @MayoOnTheBrain @DavidErritzoe @CRodriguezMDPhD @FredBarrettPhD @N_Gukasyan @NeuroBanks @amykooz @TheBorisLab and others I may have missed.

@OneMindOrg @ACSPublications @ACSChemNeurosci @Psyched_Alpha @mindmedco @Engrail_Tx @JHPsychedelics @SinaiBrain @Xylo_Bio @PsyPharmacists @CoherentCorp @GilgameshRX @UMconsciousness @UWTCRPS Great lineup of speakers from preclinical to clinical, drug discovery to plasticity, and animals to human research. 🔥. @RachelYehuda @ExistWell @zenbrainest @lab_nichols @akaye @KateNautiyal @ArgelAV @NUro_science @LabWalsh @ClaireFoldi @bita137 @KepecsLab @DR_WANG_SIBCB . .

Big thank you to contributors for supporting speakers and early-career travel awards. 🙏. @OneMindOrg @ACSPublications @ACSChemNeurosci @Psyched_Alpha @mindmedco @Engrail_Tx @JHPsychedelics @SinaiBrain @Xylo_Bio @PsyPharmacists @CoherentCorp @GilgameshRX @UMconsciousness @UWTCRPS

This work was spearheaded by PhD student Hao Wu. The #SCN2A community is incredible. We got interested after first hearing about the gene at the @SimonsFdn Investigator Meeting. Then Hao attended the @FamilieSCN2A #SCN2Aconference, which motivated us to pursue the study. 🙌.

During the adaptive matching pennies task, dendrites of IT pyramidal neurons have reward- and strategy-related signals, but were lost in Scn2a+/- mice, suggesting a potential dendritic basis for their inflexible decision-making.

As an aside: we think this behavioral paradigm is super cool, because we can program the computer to pursue other strategies too… for example another easier "alternate" strategy, and the mouse would adapt differently (!!).

Control mice would adjust to the competitive pressure, where Scn2a+/- mice showed cognitive rigidity and were unable to adapt.