Marco Pignatelli
@Pignatelli_Lab
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PI at @WUSTLmed, physician-scientist, synaptic physiologist interested in affective disorders. Personal, unaffiliated, account.
St Louis, MO
Joined April 2016
Why do individuals with late-stage cancer sometimes struggle with motivation and experience profound apathy? In this multi lab effort @KepecsLab @JanowitzTobias and my lab we are tackling this question 👇🏻 😊
science.org
Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical...
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Excellent write-up on some of our recent findings. @BBRFoundation . Researchers Trace How Ketamine Acts on Specific Brain Circuits and Synapses to Relieve Anhedonia | Brain & Behavior Research Foundation
bbrfoundation.org
Researchers have published a highly detailed account of a mechanism through which ketamine, a rapid-acting antidepressant, alters plasticity, or the strength of connections between neurons, and in so...
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👇🏻.
Please Share! Nominations are open for the Peter Gruss Young Investigator Award!.This award celebrates early-career scientists who have made outstanding contributions to the scientific community through collaboration, creativity, and curiosity-driven research. Know someone doing
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RT @dr_alexharris: This chart made by Peter Gleick shows the proposed cuts to science graphically. This is bad for America. Please ask Co….
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Norepinephrine signals through astrocytes to modulate synapses | Science. Congrats @papouinlab and co-authors 🥳
science.org
Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-le...
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Prefrontal encoding of an internal model for emotional inference | Nature
nature.com
Nature - Neurons in the rodent dorsomedial prefrontal cortex encode a flexible internal model of emotion by linking directly experienced and inferred associations with aversive experiences.
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Nice!.
🎉Thrilled that the lab’s first paper is out today in @Nature! Credit to the amazing @cesca_gst, @HernyMV and @YviJohansson. Thank you to everyone involved in this massive effort!
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RT @BPoD_s: Cancer muscle wasting-associated apathy is result of tumour-induced inflammation & brain circuitry interaction. 📷 Xiaoyue Aelit….
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Very proud to see this beautiful artwork, highlighting @FedeLucantonio's paper, made by our talented former lab member @qwinkledink on the cover of @NeuroCellPress ! 🤩 Aleesha is now launching her career as a digital illustrator please, check her work!.
aleeshashi.com
Illustrations by Aleesha Shi, watercolor and digital artist.
Our latest issue is out: The cover is for the study by Lucantonio et al. on ketamine's anti-anhedonic action. Artist credit: Aleesha Shi. Read the paper here: And a preview of this work by Colleen McClung:
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RT @ScienceMagazine: In a new Science study, researchers describe a neural circuit underlying cachexia-related apathy in a mouse model of c….
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Very nice study 😊.
This study identified a common brain circuit centered on the hippocampus's posterior subiculum linked to lesions causing secondary psychosis. @fredschaper_ @shansiddiqi.
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Very interesting ☺️.
New issue in Am J Psych @APA_Publishing focusing on schizophrenia. We report a decrease in synapse loss in schizophrenia-derived organoids by inhibiting KAT enzymes @KynexisTx
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Important study. 😊.
A multi-institutional investigation of psilocybin's effects on mouse behavior #biorxiv_neursci.
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RT @biorxiv_neursci: Synapses drive local mitochondrial ATP synthesis to fuel plasticity #biorxiv_neursci.
biorxiv.org
Our brain constantly forms new memories and stabilizes existing memories. To achieve such cognitive flexibility, the brain is wired by plastic synapses that are hotspots of energy consumption....
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Cool !.
Online now: An integrated microfluidic and fluorescence platform for probing in vivo neuropharmacology
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Beautifully written. Must read 👇. Check out this article:
cnn.com
Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concer...
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Nice !.
DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning.
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Cool !. EPSILON: a method for pulse-chase labeling to probe synaptic AMPAR exocytosis during memory formation | Nature Neuroscience
nature.com
Nature Neuroscience - Kim and coworkers describe a technique, EPSILON, to map AMPA receptor exocytosis, a proxy for synaptic plasticity, in mice. The authors demonstrated a correlation between AMPA...
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Very important body of work😍. Glutamate gating of AMPA-subtype iGluRs at physiological temperatures | Nature
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