Kate Miroshnikova
@KateMiro1
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Bioengineer interested in mechanical forces & chromatin @WickstromLab @MPIAge @HiLIFE_Helsinki @OlinCollege @UCSF_BioE alum
Joined March 2020
Our study uncovering a new mode of how growth factors exert their effect on cell state via modulation of nuclear mechanophenotype is live - check it out! #mechanobiology #nucleus
How do #stemcells integrate information to make fate decisions? Check out our latest preprint where we find that growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to determine whether to retain or exit #pluripotency🧵👇 https://t.co/CB1vIDUFbX
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Excited to see this great collaborative work out 🤩🤩🤩 congratulations team!
#1 Happy to share our last work published in @NatureCellBio about a new cell cycle checkpoint that senses nuclear shape and mechanics to guarantee genome integrity https://t.co/npMBatW69k. Great work from @sol_herve and Andrea Scelfo in close collaboration with @KateMiro1.
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SAVE THE DATE! 📅 The Stem Cells and Cancer Conference will take place 28 Sept – 01 Oct 2025 in St Julians, Malta! 🇲🇹 Join @JonesLabUCSF, @PlathLab, @MariaPAlcolea & @KateMiro1 for this continuation of the GRC 'Stem Cells and Cancer' series. For more information & to register ➡️
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Looking for #mechanobiology enthusiasts for an exciting new project - apply and spread the word! 🤩
We are looking for a: POSTDOC (M/F/D) Interested in implementing cutting-edge technologies, developing new tools, and their integration with spatial transcriptomics and mechanical measurements? Then apply 'til Dec. 31, 2024! https://t.co/N1Z7cuibaL
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So excited to see this out! Congratulations team 🤩🎉🤩
Excited to share our latest work on an image analysis paradigm that combines cell state and morphology analyses of patient biopsies at single cell resolution to uncover clinically relevant head-and-neck #cancer phenotypes! @CellCellPress
https://t.co/ijdKjiwHXl tweetorial👇
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@IvaskaLab latest exciting findings in collaboration with @WickstromLab @KateMiro1 @scita_lab @KaroPunovuori driven by Jasmin Kaivola - Restoring mechanophenotype reverts malignant properties of ECM-enriched vocal fold cancer
biorxiv.org
Increased extracellular matrix (ECM) and matrix stiffness promote solid tumor progression. However, mechanotransduction in cancers arising in mechanically active tissues remains underexplored. Here,...
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Check out this interview from our rockstar postdoc @Clem_Villeneuve 🤩 Btw, she is on the job market, any institute would be lucky to have her!
Pathway to Independence – an interview with Clémentine Villeneuve Read this interview with our PI Fellow @Clem_Villeneuve to find out more about her research background, her hopes for the PI programme and her future research questions: https://t.co/quNzryJXzY
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@abbybuch @ASCBiology @LuskingL @Bahmanyarlab @DanStarrUCDavis On the plus side, @LuskingL @Ruprecht_Lab @KateMiro1 and I are organizing a FASEB nuclear #mechanobiology conference to be held in October 2025, which should offer a great forum for the latest science and networking. Stay tuned for more information to come soon!
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Beyond thrilled to present our first (!) work @TheCrick! A tour de force by @tobyandrews et al combining imaging, solid morphometrics, theory, perturbations to show how a developing heart grows and scales up its morphological complexity to keep beating... https://t.co/RghtQtmYxF
Pumped to share our latest and first (!) work from @_Priya_R lab @TheCrick! Using the powers of #zebrafish, we uncover how multiscale mechanochemical coupling drives morphological and functional maturation of the developing heart 🫀 Stay tuned for the🧵 https://t.co/0MxXSef9bJ
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Our start-up-to-be is looking for a CEO and co-founder! Are you passionate about improving cancer diagnostics and treatment and interested in working with cutting edge science and a young and dynamic team? This is for you👇 https://t.co/Zqwh1RINYi
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Looking forward to reading this 🤩 !!!
Now Online Mechanical state transitions in the regulation of tissue form and function https://t.co/mRg36bqkvA
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#1 Happy to share our work “Specialized replication mechanisms maintain genome stability at human centromeres” @MolecularCell from A. Scelfo, A. Angrisani and T. Wilhelm @institut_curie @CNRS where we provide the causes of centromere fragility. https://t.co/2nxkj1mFGm
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CluMPS: A reporter of small clusters. Now in print at @CellSystemsCP! A monumental/rigorous effort led by @confocalTom ( thread below). See also excellent press release from Penn Eng. @Ian_Scheffler
https://t.co/xLyZs6rZYu
https://t.co/AyURcETMy7
preprint on CluMPS now updated!: -sims/experiments of target/reporter concentration - CluMPS reporting on endogenous proteins, both unmodified and tagged -confirmation that small clusters are in fact small ( FCS with @MicelleYoucelle /Liz Rhoades https://t.co/WXhNIXoE1B
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Did you ever wonder how changes in physical properties of an organ across compartments and scales orchestrate its development? Check out this fantastic piece of work!. Congratulations to the whole team! @Clem_Villeneuve, @KateMiro1, @WickstromLab
nature.com
Nature Cell Biology - Villeneuve et al. report coordination of contractile forces during mammalian hair follicle development, with actomyosin contractility and mechanical forces from the epidermis...
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So happy to see this out 😍🤩😍Special congrats to my brilliant colleague and friend @Clem_Villeneuve for her outstanding science! Follow her for more amazingness to come 💪
Very happy to see our preprint on epithelial mechanics in hair follicle morphogenesis now published https://t.co/Or6vRbEkuK . Congratulations @Clem_Villeneuve @alihashmiii @IreneYlivinkka and team! @STEMMProgram @MPI_Muenster @helsinkiuni For a tweetorial see 👇
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Very interesting paper from @WickstromLab. Congratulations Sara and the team
nature.com
Nature Cell Biology - Villeneuve et al. report coordination of contractile forces during mammalian hair follicle development, with actomyosin contractility and mechanical forces from the epidermis...
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Congratulations @WickstromLab and team on this beautiful study!🥳🌟🥳 Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture | Nature Cell Biology
nature.com
Nature Cell Biology - Villeneuve et al. report coordination of contractile forces during mammalian hair follicle development, with actomyosin contractility and mechanical forces from the epidermis...
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Interested in nuclear #mechanobiology and attending the @ASCBiology/@EMBO #cellbio2023 meeting in Boston next week? Make sure to visit the "Nuclear Mechanobiology" subgroup session on Sat, Dec. 2, from 1:00 to 3:30pm with an excellent lineup of speakers. https://t.co/vbBvJAXjhE
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I am grateful and thankful to our collaborators, @RAHULSARATE15, @yura__song and Alejandro Sifrim for the bioinformatic analysis, @KateMiro1 and @WickstromLab for the mechanobiology analysis and @ImpensLab for the proteomic analysis.
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https://t.co/BpChjlNCsP A nice summary of our new paper @NatureComms explaining a paradigm shifting finding about #gastrulation: the #ectoderm does not lose the pluripotency signature, which enables maintenance of the exceptionally high stemness of #neuralcrest @NIDCR
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