Impens Lab
@ImpensLab
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We study host-bacteria interactions using Listeria and MS-based Proteomics with a focus on Ubiquitin-like modifications (e.g. ISG15) and MHC complex peptides.
Ghent, Belgium.
Joined October 2021
RT @Patrick14342109: 🚀 Boosting bacterial immunopeptide discovery! Our bioinformatics workflow integrates 4 search engines with follow-up….
pubs.acs.org
Mass spectrometry-based discovery of bacterial immunopeptides presented by infected cells allows untargeted discovery of bacterial antigens that can serve as vaccine candidates. However, reliable...
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RT @Patrick14342109: Happy to share our immunopeptidomics pipeline using four search engine with follow-up rescoring to boost confident IDs….
biorxiv.org
Mass spectrometry-based discovery of bacterial immunopeptides presented by infected cells allows untargeted discovery bacterial antigens that can serve as vaccine candidates. Reliable identification...
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Excited to share our latest MCP article uncovering > 6,000 MHC class I immunopeptides in Listeria-infected mice, including 12 Listeria peptides and a potent CD8+ T cell epitope. Many thanks to all co-authors for the excellent work! Read more at
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RT @AnStaes: Here it is: our paper on the benefit of using in silico predicted libraries in DIA 🎉🎉🎉😎🙏. @KrisGevaert….
pubs.acs.org
Data-independent acquisition (DIA) has become a well-established method for MS-based proteomics. However, the list of options to analyze this type of data is quite extensive, and the use of spectral...
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RT @AnStaes: Proud to have it out there! The setup that boosts our throughput!💪😎
pubs.acs.org
With current trends in proteomics, especially regarding clinical and low input (to single cell) samples, it is increasingly important to both maximize the throughput of the analysis and maintain as...
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RT @RemautHan: Meet SlyB, a lipoprotein that forms stress-induced #lipidraft in the bacterial outer membrane. Off the hands of the great @….
nature.com
Nature - SlyB, a lipoprotein in the PhoPQ stress regulon in Gram-negative bacteria, forms stable stress-induced complexes with the outer membrane proteome.
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RT @VIBLifeSciences: 👏Congratulations to @kkariko & @weissmanlab on becoming #NobelPrize laureates. A lifetime achievement celebrating the….
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We are looking for a #postdoc position in #immunopeptidomics @ VIB & UGent with proteomics/peptidomics expertise to develop novel antibacterial #vaccines, see A warm call to proteomics postdocs to apply!.
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RT @VIB_CMB: Research on #Moyamoya disease @ImpensLab: "Rare diseases result from dysregulated, often yet unknown molecular pathways. Inves….
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We are very excited and extremely grateful to receive this #ERCCoG grant from @ERC_Research. It is a recognition for the whole team and we thank @VIB_CMB @ugent @ugent_fge @VIBLifeSciences @FWOVlaanderen and many others for their continuous support!.
🎊 More wonderful @ERC_Research news! @ImpensLab has received an #ERC Consolidator grant for his research on #Moyamoya disease (#MMD). With this grant, the Impens Lab hopes to provide unprecedented insight into MMD-related immune responses! 👉
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Another wonderful story from the Radoshevich lab. A must-read (and watch!) for all Listeria and comet tail aficionados.
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RT @VIBLifeSciences: 💉 Francis Impens and team (@ImpensLab @VIB_PRC @VIB_CMB) design an mRNA vaccine against Listeria and open the door for….
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Finally published! .Thank you all co-authors for their priceless contribution!. Here we designed mRNA vaccine formulations against Listeria using immunopeptidomics. Looking forward to continue our efforts to tackle other intracellular bacterial pathogens.
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Happy to share our new review on Moyamoya disease and RNF213, a disorder for which the etiology is still unknown. Here, we examined the recent body of literature suggesting immune-related insults as a trigger for Moyamoya disease onset.
cell.com
Moyamoya disease (MMD) is a rare cerebrovascular disorder with unknown etiology. MMD is characterized by progressive narrowing of arteries of the brain and the formation of a compensatory network of...
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RT @vibbioinfocore: First day of the 4-day BePA Proteomics Summer School @ VIB starting with interesting talks on Proteomics applications a….
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Very happy to share our work on mRNA vaccine formulations against Listeria. MS and immunopeptidomics hold great promise to uncover antigens for next-generation vaccines, especially for intracellular bacteria. Incredibly grateful to all co-authors for their dedication and efforts!.
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