Dan Starr
@DanStarrUCDavis
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Professor, Cell Biologist, Nuclear Envelope Geek, Allen Distinguished Investigator, co-Director of PREP, and Author of Cell Biology Text, views are my own.
Davis, CA
Joined November 2013
Check out the latest from our lab by @hongyan_hao on the role of ANC-1 in C elegans out now in eLife
elifesciences.org
The giant KASH protein ANC-1 maintains the integrity of the cytoplasm to anchor nuclei, ER, and other organelles within the cell.
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It's been so fun working with @gwgl1979 the past 5 years!
Excited to be featured in @naturemethods on co-directing a lab with @DanStarrUCDavis @ucdavis. Thanks to Vivien Marx for the thoughtful piece on collaborative lab models.
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Therapeutic implications: target ribosome production pathways, not just nuclear proteins. @DanStarrUCDavis (6/6) #CellBiology #MuscularDystrophy #FrontierScience
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🧬BREAKING!🪱Plot twist: Cells aren't meditation pools, they're overcrowded concerts with VIP ropes everywhere! Our @ScienceAdvances study reveals worm cells are insanely crowded AND compartmentalized. Ribosomes = packing peanuts, ANC-1 = the bouncer!
science.org
Living tissues maintain unique intracellular biophysical properties under the control of cytoplasmic constraints and crowding.
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🧬Want the full story of our @ScienceAdvances paper without the science jargon? Our @ucdavis department broke down our "cells are crowded AND constrained" findings in plain English! Perfect explanation of why worm cells are nothing like cultured cells 🪱🌠 https://t.co/KdBOTDGCx3
biology.ucdavis.edu
In a new study published in Science Advances on September 10, a team of UC Davis researchers tracked the movement of fluorescent particles inside the cells of microscopic worms, providing unprecede...
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🚨Our fabulous graduate student Selin's paper on how the KASH protein UNC-83 regulates the activity of kinesin-1 to control developmental stage-specific nuclear migration is out! Another great collaboration between the Starr-Luxton and MOM labs @ucdavis. https://t.co/ODvXAICslh
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🧵 1/8: Excited to share our new paper on how heterochromatin (tightly packed DNA) helps cell nuclei migrate through tight spaces in #Celegans! Published in @genetics_asa #CellBiology #NuclearMigration
https://t.co/Su4OEbCu4w Congrats to 1st author Ellen and @DanStarrUCDavis!
pubmed.ncbi.nlm.nih.gov
Nuclei adjust their deformability while migrating through constrictions to enable structural changes and maintain nuclear integrity. The effect of heterochromatin anchored at the nucleoplasmic face...
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🧬 NEW RESEARCH ALERT! Starr-Luxton Lab grad student Selin discovered how cells control nucleus movement using KASH protein UNC-83 isoforms as molecular switches. Critical for organ development and preventing genetic disorders! 🧪🔬
biorxiv.org
Nuclear migration plays a fundamental role in development, requiring precise spatiotemporal control of bidirectional movement through dynein and kinesin motors. Here, we uncover a mechanism for...
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Ukraine, you are not alone. Many Americans, including me, stand with Ukraine and are completely embarrassed today. 🇺🇦🇺🇦🇺🇦
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https://t.co/BBiG2N9Tkr Just published! We uncovered a molecular machine that connects the cell's two major structural networks revealing how cells accomplish precise internal reorganization - a process disrupted in diseases ranging from cancer to multiple sclerosis.
science.org
Nesprin-2 Giant links the nucleus to the cytoskeleton, enabling actin transport and nuclear movement through kinesin-1 activation.
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Despicable. As families grieve, Trump should be leading, not lying. We put safety first, drove down close calls, grew Air Traffic Control, and had zero commercial airline crash fatalities out of millions of flights on our watch. President Trump now oversees the military and the
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DEI only existed because white people were racist. They had the opportunity to hire based on merit, and they hired their unqualified white friends every time. DEI isn’t racism. It’s a solution to historical racism.
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Why does RFK Jr. continue to spread the lie that the HPV vaccine causes cervical cancer when countries around the world have shown its effectiveness in preventing cancers? Because he makes money on lawsuits filed against the HPV vaccine manufacturers. 1/
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"I must be in the front row!" ~ Classic Miller Lite Beer commercial starring "Mr. Baseball" Bob Uecker (1984) #MLB #Legend #RIPBobUecker
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The magic of Major League doesn’t exist without Bob Uecker. His commentary was perfect and no other voice could have filled that role. A legendary commentator whose voice will be missed forever. Rest easy Bob.
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Big news! We’re thrilled to announce that #PMB member Dr. Aldrin Gomes has been named a Presidential Awardee for Excellence in Science, Mathematics, and Engineering Mentoring (PAESMEM). Congratulations to @gomes_lab on this much-deserved achievement!🌟🔬 https://t.co/TmzsId0Dnh
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🧵1/ Excited to share our latest review on how organoid technology is transforming pancreatic cancer research, published in Experimental & Molecular Medicine. Here's a breakdown of the key points.
nature.com
Experimental & Molecular Medicine - Pancreatic cancer is a challenging disease to study and treat. This article discusses how researchers have developed pancreatic organoids to better study...
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Extremely honored and humbled to be awarded the Presidential Early Career Award for Scientists and Engineers (PECASE). This is a testament to the work of the amazing people in my lab current and previous. @ucdavis @ucdavisbiology @CAMPOSUCDavis1
https://t.co/V7cu80f95w
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@ptaavreollquii @gwgl1979 @ptaavreollquii Halo! here is your unroll: https://t.co/EAQm5C6dcU Enjoy :) 🤖
threadreaderapp.com
@gwgl1979: How are cells in living tissues different from those in a dish? This question has puzzled scientists for decades. In our new preprint, we studied C. elegans roundworms to uncover how cells...
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How are cells in living tissues different from those in a dish? This question has puzzled scientists for decades. In our new preprint, we studied C. elegans roundworms to uncover how cells maintain unique internal environments. The results surprised us.
biorxiv.org
Understanding how cells control their biophysical properties during development remains a fundamental challenge. While cytoplasmic macromolecular crowding affects multiple cellular processes in...
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