
Toby Andrews
@tobyandrews
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Developmental Biologist | Postdoc @TheCrick Organ Morphodynamics Laboratory | PhD @Cambridge_Uni | Form, Development, Evolution
London, UK
Joined June 2016
Pumped to share our latest and first (!) work from @_Priya_R lab @TheCrick! Using the powers of #zebrafish, we uncover how multiscale mechanochemical coupling drives morphological and functional maturation of the developing heart 🫀. Stay tuned for the🧵 .
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RT @Dev_journal: Morphogens in the evolution of size, shape and patterning. In this Review, Lewis Mosby, Amy Bowen and @z_hvas @TheCrick @U….
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RT @jake_cs_: It was a lot of fun collaborating with @tobyandrews @_Priya_R on modelling mechanisms of organ-scale stretch. Check out Toby’….
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@jake_cs_ @mc_mcramel @Kirti_Guptatifr @briscoejames @_Priya_R @CALM_STP And get in touch with any questions, we'd love to hear what you think!.
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Big thanks and congrats to all authors, @jake_cs_ @mc_mcramel @Kirti_Guptatifr @briscoejames @_Priya_R, plus @CALM_STP, and the Crick aquatics team 🐟🐟🐟.
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@jake_cs_ found tissue stretch occurs in a non-linear manner, at a tipping point when a critical fraction of cells (~40%) has activated Notch and dampened actomyosin tension. This behaviour enables robust tissue growth in response to small changes in input signals (8/11)
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But then, how do variable cellular properties yield reproducible changes in organ shape, size and function? 🤔 . We teamed up with @jake_cs_ to answer this question using a 3D vertex model (7/11)
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RT @_Priya_R: We are recruiting! Fully funded post-doctoral positions are available. Interested in #morphogenesis #imaging #zebrafish? Join….
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How do embryos build organs with the right shape, size and function to keep our bodies ticking?🫀🫁👀. @_Priya_R and I give our take here, in a rollercoaster ride from local cell behaviors to organ-scale physiology and back .
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