Isnard Pierre
@IsnardPierre1
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MD, PhD, Kidney Pathology, Institut Necker Enfants Malades, Paris, France
Joined November 2022
Our new paper in @naturemethods led by @vanvanka123 @MingboCheng Jitske Jansen with @KuppeChristoph
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Our new study in Science is out! CKD progresses slower in females. 🔹Estrogens boost female renal progenitors to produce new podocytes for pregnancy adaptation. 🔹Loss of this mechanism causes preeclampsia, maternal CKD risk & fewer nephrons in offspring.
science.org
The global burden of kidney disease displays marked sexual dimorphism. Lineage tracing and single-cell RNA-sequencing revealed that starting from puberty, estrogen signaling in female mice supports...
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Spatial-DMT is now published in @Nature ! For the first time, we can simultaneously map DNA methylation and RNA transcription in tissue context. Great collab with @zhouwanding lab. Big congrats to Chin @Chin72155594 , Hongxiang @HongxiangFu and team!
nature.com
Nature - DNA-methylation and gene-expression profiling of tissue sections at near single-cell resolution can be used to create detailed spatial maps showing how methylation and transcription...
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Very proud to have participated in this amazing work showing how we can combine the strengths of multiple spatial transcriptomics technologies! Congratulations to Qiao and to the wonderful leadership of Ben Humphreys!! https://t.co/8HvL9zNBxt
nature.com
Nature Communications - Kidney injury progression involves complex changes in cellular composition and spatial organization. Here, the authors use multimodal spatial transcriptomics to reveal...
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Antigens in membranous nephropathy: discovery and clinical implications
nature.com
Nature Reviews Nephrology - Since the discovery of PLA2R, several target antigens associated with membranous nephropathy have been identified. This Review describes the distinct clinical...
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Nature research paper: NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity https://t.co/oljbkCdBlA
nature.com
Nature - An NNMT inhibitor reduces tumour burden and metastasis in multiple mouse cancer models and restores immune checkpoint blockade efficacy by decreasing cancer-associated-fibroblast-mediated...
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Congratulations to @HumphreysLab, Chief, @WashUNephrology, on joining the editorial board of @jclinicalinvest as Associate Editor! #Nephstrong @WashUDeptMed
https://t.co/DzkrJmoggf
nephrology.wustl.edu
WashU Nephrology proudly congratulates Benjamin Humphreys, MD, PhD, Chief of the Division of Nephrology, on his appointment as an Associate Editor for the Journal of Clinical Investigation (JCI). A...
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Fibrosis: cross-organ biology and pathways to development of innovative drugs | @NatRevDrugDisc @rkramann
nature.com
Nature Reviews Drug Discovery - Fibrosis is a key characteristic of a range of chronic diseases that has been challenging to target with drugs. This Review highlights core pathways active in...
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Happy to share our recent work: TSC-associated tubulointerstitial kidney disease. https://t.co/kazDadH1k1 Thanks to @KIReports for publishing our work !
kireports.org
Tuberous sclerosis complex (TSC) is a rare autosomal dominant genetic disease caused by TSC1 or TSC2 mutations, leading to mammalian target of rapamycin (mTOR) overactivation.1 It is characterized by...
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Thrilled to share our work and truly honored to share senior autorship with @FabiolaTerzi ! Thanks @ScienceTM for publishing our work !
science.org
YAP overactivation in podocytes triggers proliferation of parietal epithelial cells, driving the development of crescentic glomerulonephritis.
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[PUBLICATION] Podocyte-specific YAP activation drives crescentic glomerulonephritis via cross-talk with parietal epithelial cells. 🌙 A study from the Terzi & Pontoglio labs now out in Science Translational Medicine @ScienceMagazine. https://t.co/Y8lsuCaZcW
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Multiomics single-cell optimal transport moscot.spatiotemporal An #OptimalTransport-based common coordinate framework to map & align #SpatialTranscriptomics with single-cell/-nucleus omics data scalable for millions of cells across multiple time points vs Tangram gimVI
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New technology in @AJPathology enhances cellular and molecular insights into #kidneylesions by combining traditional histopathology and #spatialtranscriptomics
https://t.co/dMGRtnQRxL
@ASIPath
@chhavic
@HumphreysLab
@IsnardPierre1
#molecularmicroscopy
#precisionpathology
elsevier.com
Elsevier’s American Journal of Pathology study combines traditional histopathology and spatial transcriptomics, advancing molecular microscopy
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Our spatial multi-omics technology that co-profiles five modalities is now published in Nature Methods @naturemethods! Huge thanks to @marekbartosovic, @DrMingyaoLi, and my amazing team, including postdoc @pengfeo and PhD student @LiranMao! https://t.co/QMBgTTiIqQ
nature.com
Nature Methods - Spatial-Mux-seq offers a multimodal spatial platform capable of profiling multiple molecular modalities, including the transcriptome, chromatin accessibility, histone modifications...
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TET2 germline variants impair DNA repair and activate cytosolic nucleotide sensors, promoting kidney disease. It's a novel risk gene identified via GWAS integration in over 800 loci. Genomics Research Innovations, PMID:39511169, Nat Commun 2024, @NatureComms
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Our most recent work out today @NatureCVR led by Tore Bleckwehl and @sikandhayat in collboration with @novonordisk @ivivek87 Simon Baumgart 👇👇👇
nature.com
Nature Cardiovascular Research - Bleckwehl et al. present a spatial transcriptomic map of atherosclerotic plaques across disease stages, revealing cellular recruitment and migration patterns and...
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The wait is over!! We are thrilled to announce that we have chosen Spatial Proteomics as 2024’s Method of the Year! 🥳 For more on Spatial Proteomics and a road map to this special issue, please see this month’s Editorial or read on in this thread. https://t.co/phXooJzJda
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