Rafael Kramann, MD PhD
@rkramann
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Chair Department of Medicine 2 @RWTH #Nephrology #Fibrosis #HeartFailure #MultiOmics #twindad @ErasmusMC @MDIBL Founder Sequantrix
Joined May 2012
At #KidneyWk? Celebrate and listen to the ASN-American Heart Association Donald W. Seldin Young Investigator Award winner, Rafael Kramann, who will speak on “Cell by Cell, Space by Space: Unraveling Fibrosis in the Kidney and Heart” on Friday, November 7. https://t.co/mTu6wPEgKz
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Great morning run at the Galveston beach ! Beautiful place !! It was really an amazing visit @utmbhealth can wait to see what comes out of this collaboration 🚀🚀🔥 Thanks again to the terrific team @utmbhealth and president @JochenReiser for the invite.
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Visiting @UTMB in Galveston-an inspiring institution with outstanding leadership under President @JochenReiser Exciting to see the strong vision for advancing translation & entrepreneurship in cardiovascular, kidney & metabolic health-delivering for patients in Texas and globally
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Sikander Hayat gives a great talk on our NephroAix LLM model for target discovery in CKD #kidneyWk @Sequantrix
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Warm congratulations to @rkramann for the Donald W Seldin young investigator award by @ASNKidney
@ERAkidney is super proud of you!!!!!!👏🏼👏🏼👏🏼
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Congrats to ASN award winners and ISGD committee members @KSusztak @rkramann @SannaCherchiLab, and Laura Mariani @MiKTMC — and to all this year’s award winners! We’re inspired by and grateful for you 🌟
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“Fibrosis is not just a bystander of kidney disease, it’s also a driver” says @rkramann in his lecture accompanying his Donald Seldin Award from @ASNKidney. Rafael shows us what’s possible once exceptional talent, hard work and humility meet each other to impact science and human
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Terrific talk by @turgay_saritas at #KidneyWk on conserved multicellular programs across kidney diseases 🚀🔥🔥
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Cells have life paths too! 🚀 PHLOWER decodes branching cell “journeys” from multimodal single-cell data and discovers what pushes them off track in kidney organoids. A new tool for mapping development with precision. @rkramann 🏆
nature.com
Nature Methods - PHLOWER leverages single-cell multimodal data to infer complex, multi-branching cell differentiation trajectories.
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Thrilled to share PHLOWER, which uses Hodge Laplacians to build trajectory-level embedding for inferring complex cellular differentiation trees from multimodal (RNA+ATAC) single-cell data. By @MingboCheng @jansen_jitske with @rkramann @KuppeChristoph
https://t.co/LTdYdkrp2Z 1/7
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Our new paper in @naturemethods led by @vanvanka123 @MingboCheng Jitske Jansen with @KuppeChristoph
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Exciting news from our spinout @Sequantrix 👇👇
Sequantrix announces a research collaboration with leading European biotech @argenxglobal to apply its AI-driven DiseaseDecoder platform in drug development initiatives. 👇
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💡 The integrated heart failure atlas offers: A harmonized snRNA-seq dataset Deep multi-omic & AI analyses A framework for therapeutic target discovery
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AI-driven drug discovery Our AI agent nominated ZLN005, a small molecule that boosts mitochondrial biogenesis. Experimental validation showed a protective effect in cardiomyocytes — illustrating the atlas’s translational power.
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Genetic insights via GWAS integration By mapping GWAS summary statistics onto the atlas, we linked calcium-handling pathways in cardiomyocytes to genetic risk — highlighting known druggable targets and prioritizing new ones.
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Cell type–specific analysis Using the atlas, we identified disease-associated cell states, performed pathway & cell–cell communication analyses — unlocking insights to accelerate target discovery.
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Human Heart Failure Atlas We integrated & harmonized single-nucleus RNA-seq (snRNA-seq) data from multiple studies - enabling cross-disease comparison and deep exploration of cardiac biology.
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