Christoph Kuppe
@KuppeChristoph
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Professor @RWTH, Nephrologist, Emmy Noether Group Leader. #CKD #glomerulus #FSGS #Heart #spatial multiomics.
Aachen, Deutschland
Joined January 2018
🎉 Happy to share our first 📜 2024!🔬 Our review article in @GenomeMedicine on the innovative use of spatial multi-omics. Discover how these technologies are unlocking new understandings of cardiovascular disease. 🚀 https://t.co/DjlEMgHeeD
@UniklinikAachen @SpringerNature @RWTH
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Our new study in Science is out! CKD progresses slower in females. 🔹Estrogens boost female renal progenitors to produce new podocytes for pregnancy adaptation. 🔹Loss of this mechanism causes preeclampsia, maternal CKD risk & fewer nephrons in offspring.
science.org
The global burden of kidney disease displays marked sexual dimorphism. Lineage tracing and single-cell RNA-sequencing revealed that starting from puberty, estrogen signaling in female mice supports...
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My opening comments at #LINO25. Let's make sure others enjoy and understand the benefits of science. https://t.co/IVmVaScVm0
timeshighereducation.com
Frances Arnold says US science is ‘paying the price’ for not explaining benefits of research funding for ‘far too long’
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Ultivue by Vizgen’s new ADC OmniVUE™ Panels integrate advanced InSituPlex® assays with the STARVUE™ image data science pipeline, bringing speed, scale, and pathology-grade precision to clinical and translational research. Learn more: https://t.co/Z6t66NrmyV
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Die EKFS ehrte heute im Rahmen des zweiten Alumni-Tags in Frankfurt am Main fünf herausragende Wissenschaftlerinnen und Wissenschaftler mit dem Publikationspreis 2025. Herzlichen Glückwunsch an @grieshaber, @SusanneLMeinert, Jan-Michel Heger, Felicitas E. Hengel, Marcel S. Woo
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Sicklinger & colleagues developed a new #ultrasound-guided method to induce #HeartAttacks in mice, allowing precise control & real-time monitoring without the need for invasive surgery. Learn more at https://t.co/yqrOd4AS7o
@volkersmirko @junedh_amrute @rkramann
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Just met Alex @biogerontology CEO at @InSilicoMeds at #AACR25 — exciting to exchange ideas on novel targets in fibrosis and ageing! Great discussions on novel mechanisms and #AIDrugDesign in organ fibrosis. Stay tuned for what’s next with @InSilicoMeds! 🤝
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A powerful moment at #AACR25 as attendees stand together to champion the lifesaving impact of cancer research.
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Genetic testing can help protect the lives of you and your family members; that's why we're giving away 5,000 FREE genetic tests. Learn more: https://t.co/lbpMG8X7br
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The identification of novel targets together with technological advances is transforming our ability to effectively modulate the tumor microenvironment https://t.co/2mQ02dLMHo
https://t.co/7HS4L5weFY
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📣 Angesichts wachsender Einschränkungen der Forschungsfreiheit in den USA startet die @EKFStiftung ein neues Förderprogramm mit 10 Mio. €: Ziel ist es, exzellenten Medizinforschenden aus den USA langfristig eine Perspektive in Deutschland zu geben. ➡️ https://t.co/7QXfxpGXQA
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Don't miss the lecture by @KonradHoeft at today's @WashUNephrology research seminar; 4/15/25, noon: "A multi-modal atlas of human heart failure with preserved ejection fraction". Dr. Hoeft is a postdoc fellow in the @rkramann lab @RWTH.
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🔥New Night Science paper!! Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
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Interested in single cell genomics but need help getting started? Check out the full agenda for our Single Cell Genomics Day on Friday 4/25. All talks will be live-streamed (no registration required) at https://t.co/JqaO6urVPF
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Great study @JAMAOnc @JAMA_current! thats excactly the kind of trials which matters most for our patients! Studies on treatment de-escalation with sparing radical surgery has to be systematically performed especially as efficacy of systemic therapies increase rapidly! For GU
For select breast cancer patients with complete response to neoadjuvant systemic therapy, radiotherapy alone without breast surgery may be feasible, as no tumor recurrences were observed at 5-year follow-up. https://t.co/CTooKo9AYB
@HenryKuerer HelenMJohnsonMD @SFShaitelmanMD
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Update of Her2neu testing guideline for breast cancer #USCAP25. Intention: Increasing use of trastuzumab deruxtecan. ADCs are shaping the field in warp speed. #pathology
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We use CITE-seq, Xenium, human PET imaging, and in vivo lineage tracing to identify FAP as a marker of modulated SMCs in human coronary artery disease and show that treatment with an anti FAP bi-specific T cell engager reduces plaque burden in vivo
biorxiv.org
Vascular smooth muscle cell (VSMC) and immune cell diversification play a central role in driving atherosclerotic coronary artery disease (CAD)[1][1]–[3][2]. However, the molecular mechanisms...
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Does autoimmunity underlie minimal change disease? @hengel_f @NicolaMTomas @Tobias_B_Huber & team reports a direct pathogenic role of anti-nephrin autoantibodies in the development of podocytopathy with a minimal change disease phenotype: https://t.co/EPqs7Fu96N
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“It is hard to put into words the extent of the damage being done to the US research enterprise, which is of almost incalculable value to both the nation itself and the wider world… An assault on science and scientists anywhere is an assault on science and scientists
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🎊Fantastic work!!! This pre-print by @LE_Laurent_ @S_LevequeFort et. al introduces Brightness Demixing for simultaneous 3-target imaging using 1 laser🤯 📷 Our #DNAPAINT ready 2ry antibodies & imagers were used for vimentin, clathrin,& tubulin imaging https://t.co/KlDDPoGI8k
biorxiv.org
Single-Molecule Localization Microscopy (SMLM) has revolutionized high-resolution imaging, but the simultaneous detection of multiple fluorophores traditionally relies on spectral-based separation,...
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