Gestwicki Lab
@GestwickiLab
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The Gestwicki Lab @UCSF uses #chemicalbiology and #biochemistry to understand the #proteostasis network. This account is student run.
Joined July 2019
Proud to share this publication by our postdoc, Shweta Devi! It offers new insights into the interaction capabilities of the TPR domain to EEVD-like motifs in nonchaperone proteins.
jbc.org
The protein phosphatase 5 (PP5) is normally recruited to its substrates by the molecular chaperones, heat shock protein 70 (Hsp70) and heat shock protein 90 (Hsp90). This interaction requires the...
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Excited to share the work done by @taiawu and Zach Gale-Day on DSFWorld: an online open-source software that streamlines the planning and analysis of DSF experiments!.
onlinelibrary.wiley.com
Differential scanning fluorimetry (DSF) is a method to determine the apparent melting temperature (Tma) of a purified protein. In DSF, the raw unfolding curves from which Tma is calculated vary...
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Interested in learning how dyes might help in characterizing protein activity? . We're excited to share the development of a protein-adaptive DSF platform (paDSF), a dye-based method used to interrogate stability, dynamics, and ligand binding!.
nature.com
Nature Biotechnology - A library of fluorogenic dyes enables the measurement of protein unfolding for a large range of proteins.
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RT @ChemicalBiology: First woman to graduate from MIT was a chemist. She applied chemistry to issues like nutrition - a pioneer ahead of h….
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We’re thrilled to have Nick joining us!.
An alum of Prof. Jeff Kelly's lab, Nicholas Yan looks forward to a postdoc position in @UCSF's @GestwickiLab and @SouthworthLab, where he'll use cryo-electron microscopy to explore the structural basis of small molecules that target amyloid fibrils. More:
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Congratulations to our amazing postdoc @proteins_emma on winning a poster award at the Protein Folding Dynamics Gordon Research Conference!!! It’s a well-earned testament to her brilliance & creativity!.
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Huge congratulations to @CarolynBertozzi !!! What a well deserved honor.
BREAKING NEWS: .The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
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RT @bignerdzzy: Jumping around the mutation alphabet to hit cancer! Our new work covalent targeting of KRAS G12S is online: .
thezlab.org
The Zhang lab uses chemical synthesis to enable the study and therapeutic modulation of disease-specific targets or processes, with a particular focus on those involved in immune signaling.
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RT @FrydmanLab: Chaperones are needed for so many processes! How do you make process-specific or disease-specific chaperone inhibitors that….
cell.com
Specific targeting of distinct Hsp70 sub-networks could be used to treat different diseases, such as cancer and virus infection, while minimizing side effects. Here, Shao and Taguwa et al. address...
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Another great collaboration out today!.
Chaperones are needed for so many processes! How do you make process-specific or disease-specific chaperone inhibitors that are not generally toxic? A great collaboration with @GestwickiLab shows the way.
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RT @apwiita: …and another 1! 2nd paper in 1 wk @idferguson. Collabo w @gestwickilab @CellChemBiol: allosteric HSP70 inhibitors overcome pro….
cell.com
Ferguson et al. find that a class of HSP70 inhibitors (JG compounds) have increased potency against myeloma cells resistant to proteasome inhibitors. JGs localize to mitochondria, inhibit the...
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It was fun to be a part of this exciting work!.
…and another 1! 2nd paper in 1 wk @idferguson. Collabo w @gestwickilab @CellChemBiol: allosteric HSP70 inhibitors overcome proteasome inhibitor resistance in #myeloma #mssm. #proteomics finds surprising mechanism: block HSPA9 & destabilize mitoribosome!.
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RT @bignerdzzy: I concur. I confirm that new PIs will do everything to make their mentees successful! I contend that other hashtags are als….
thezlab.org
The Zhang lab uses chemical synthesis to enable the study and therapeutic modulation of disease-specific targets or processes, with a particular focus on those involved in immune signaling.
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RT @MatthewRavalin: Happy to share the @biorxivpreprint for my first bit of work w/ @aliceyting. Together with @heegwangroh, we built a sim….
biorxiv.org
Many existing protein detection strategies depend on highly functionalized antibody reagents. A simpler and easier to produce class of detection reagent is highly desirable. We designed a single-co...
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Check out our latest review article on non-canonical Hsp70 interactions—out now in Cell Stress & Chaperones! With the recent explosion of studies mentioning them, @oletaknowsstuff & Jason thought this timely. We hope it inspires new important research!
link.springer.com
Cell Stress and Chaperones - Heat shock protein 70 (Hsp70) is a molecular chaperone and central regulator of protein homeostasis (proteostasis). Paramount to this role is Hsp70’s binding to...
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RT @MartinUCSF: Excited to co-direct the Tau Center Without Walls @tauCWOW with Alison Goate @SinaiBrain and @GeschwindLab, working with aw….
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RT @ReganVolk: Absolutely thrilled to have this work published with RSC! Thank you again to my mentor @BalynZaro and co-authors Sara, Kate,….
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That moment when @_heyheyMONET’s #PPGRetreat poster is so good you have to stop & check it out.
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RT @ucsfpharmacy: Congrats to Taia Sean Wu @GestwickiLab, winner of the @UCSF Chancellor Award for Public Service. @taiawu decided to pursu….
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