Geschwind Lab @ UCLA
@GeschwindLab
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Integrative #Genetics, #Genomics, and #Bioinformatics, with basic and clinical #Neuroscience, of neurologic and psychiatric disease. Tweets from lab members.
UCLA
Joined September 2019
Thanks to Pico Caroni, @AllenInstitute and other organizers/sponsors for a great inaugural conference on the Neurobiology of Mental health. Fantastic program and setting in Thun, Switzerland. @LakeConferences.
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RT @mikejg84: New in @ScienceMagazine: Our paper mapping gene/isoform/splicing regulation at pop-scale during human #neurodevelopment. Maj….
science.org
Neuropsychiatric genome-wide association studies (GWASs), including those for autism spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the developing brain....
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RT @NadavAhituv: Characterizing >100,000 sequences in primary neurons and organoids and deep learning to decode regulatory activity. Amazin….
science.org
Nucleotide changes in gene regulatory elements are important determinants of neuronal development and diseases. Using massively parallel reporter assays in primary human cells from mid-gestation...
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This represents the culmination of years of work by the @NIMHgov #PsychENCODE consortium! furthering our understanding into the genetic and molecular mechanisms of neuropsychiatric conditions🧠🧬 Read more in @ScienceMagazine: #Genomics #Neuroscience.
science.org
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Proud of our UCLA CART colleagues!.
A study co-led by researchers at UCLA CART has found distinct brain connectivity patterns in six-week-old infants at risk for developing autism spectrum disorder (ASD).
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Excited to announce our new pivotal work on autism in the latest #PsychENCODE collection, see also @MarkGerstein, @mikejg84 #autism #genomics.
science.org
Genomic profiling in postmortem brain from autistic individuals has consistently revealed convergent molecular changes. What drives these changes and how they relate to genetic susceptibility in this...
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Our latest publication led by Yonatan Cooper identifying new dementia risk genes using MPRAs to screen noncoding GWAS variants of neurodegenerative disorders w/ functional validation in neurons and microglia @MartinUCSF @srikosuri @giovannicoppoIa .
science.org
High-throughput functional analysis reveals cell-type-specific regulatory networks that mediate genetic risk for dementia.
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Our latest publication from Chris Hartl characterizing brain-wide and brain region-specific gene co-expression, providing a framework to contextualize neuropsychiatric genetic risk, supporting polygenic models of disease .@kasper_lage @alexisjbatte.
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Dr. Geschwind recently served as a witness in a congressional hearing coordinated by Congresswoman Karen Bass. His testimony focused on introducing Autism Spectrum Disorder. Take a few minutes to listen to Dr. Geschwind's statement:
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RT @jorsmo: Announcing the 1st Annual Conference on Precision Psychiatry! Grateful to our amazing speakers @NIMHDirector @AllofUsCEO @WrayN….
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RT @Aaron_Gordon1: Our paper looking at the long-term maturation of cortical organoids is out! #organoids #brainorg….
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Dr. Geschwind leads IPH and played a major role in securing this gift. We are very thankful to our donors, Dr. Allen and Charlotte Ginsburg!. Read more:
newsroom.ucla.edu
The Ginsburg Center builds on teamwork among scientists and physicians to advance research, enhance patient care for genetic conditions.
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Thrilled to share that UCLA received a $29M gift to establish a center within the Institute for Precision Health (IPH). which will enable Scientists & physicians to work side by side to examine the role of genetics in disease and develop therapies that improve patients’ lives.
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RT @WashUGenetics: Don't forget to join us for the Spring 2021 Seminar Series today at noon! Speaker is Daniel Geschwind, MD, PhD, from @UC….
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RT @finding_genius: @UCLAHealth @GeschwindLab Making Sense of Sequencing: Exome Sequencing Analysis and What's Next. Listen to it here: ht….
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RT @BiologicalPsyc1: Now out! From @GeschwindLab @UCLA : Abnormal social and repetitive behaviors and elevated striatal dopamine, a molecul….
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RT @Gokul_Ramaswami: Proud and excited to share our work on multi-omic integration in Autism! 1/4.
nature.com
Nature Communications - Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions with repetitive and restrictive behaviours. Here the authors...
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RT @RebLWalker: My commentary on integrative genomics for the interpretation of genetic loci implicated in neurodevelopmental disorders is….
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