Geschwind Lab @ UCLA
@GeschwindLab
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Integrative #Genetics, #Genomics, and #Bioinformatics, with basic and clinical #Neuroscience, of neurologic and psychiatric disease. Tweets from lab members.
UCLA
Joined September 2019
Thanks to Pico Caroni, @AllenInstitute and other organizers/sponsors for a great inaugural conference on the Neurobiology of Mental health. Fantastic program and setting in Thun, Switzerland. @LakeConferences
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New in @ScienceMagazine: Our paper mapping gene/isoform/splicing regulation at pop-scale during human #neurodevelopment. Major developmental shifts in #genetic reg., New colocalized risk genes at ~60% of #psych #GWAS loci. #PsychENCODE24
https://t.co/COilXdAAAh
science.org
Neuropsychiatric genome-wide association studies (GWASs), including those for autism spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the developing brain....
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Characterizing >100,000 sequences in primary neurons and organoids and deep learning to decode regulatory activity. Amazing work from @Chengyu_Deng_, @seawhalen, Katie Pollard, @LabNowakowski and others as part of #PsychENCODE in @ScienceMagazine. https://t.co/Y8oPRkqVVF
science.org
Nucleotide changes in gene regulatory elements are important determinants of neuronal development and diseases. Using massively parallel reporter assays in primary human cells from mid-gestation...
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This represents the culmination of years of work by the @NIMHgov #PsychENCODE consortium! furthering our understanding into the genetic and molecular mechanisms of neuropsychiatric conditionsš§ š§¬ Read more in @ScienceMagazine: https://t.co/cCinMGIRQ2
#Genomics #Neuroscience
science.org
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Proud of our UCLA CART colleagues!
A study co-led by researchers at UCLA CART has found distinct brain connectivity patterns in six-week-old infants at risk for developing autism spectrum disorder (ASD).
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Excited to announce our new pivotal work on autism in the latest #PsychENCODE collection, https://t.co/0YwmHtsxQP see also @MarkGerstein, @mikejg84 #autism #genomics
science.org
Genomic profiling in postmortem brain from autistic individuals has consistently revealed convergent molecular changes. What drives these changes and how they relate to genetic susceptibility in this...
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Our latest publication led by Yonatan Cooper identifying new dementia risk genes using MPRAs to screen noncoding GWAS variants of neurodegenerative disorders w/ functional validation in neurons and microglia @MartinUCSF @srikosuri @giovannicoppoIa
https://t.co/lTEZklEsCA
science.org
High-throughput functional analysis reveals cell-type-specific regulatory networks that mediate genetic risk for dementia.
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Our latest publication from Chris Hartl characterizing brain-wide and brain region-specific gene co-expression, providing a framework to contextualize neuropsychiatric genetic risk, supporting polygenic models of disease https://t.co/y34R5GYjQ1
@kasper_lage @alexisjbatte
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Dr. Geschwind recently served as a witness in a congressional hearing coordinated by Congresswoman Karen Bass. His testimony focused on introducing Autism Spectrum Disorder. Take a few minutes to listen to Dr. Geschwind's statement: https://t.co/05B7xbAOds.
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Announcing the 1st Annual Conference on Precision Psychiatry! Grateful to our amazing speakers @NIMHDirector @AllofUsCEO @WrayNaomi @royperlis @GregSimonKPWHRI @clesemartin @CRodriguezMDPhD @GeschwindLab
@tanzeemc @Stanford_PMHW + more! RT & Register here: https://t.co/8dZrg6u0HX
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Our paper looking at the long-term maturation of cortical organoids is out! https://t.co/odhiMtMOCh
#organoids #brainorganoids TL;DR - human cortical organoids start to resemble postnatal cortical development after 250-300 days of culturing
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Dr. Geschwind leads IPH and played a major role in securing this gift. We are very thankful to our donors, Dr. Allen and Charlotte Ginsburg! Read more:
newsroom.ucla.edu
The Ginsburg Center builds on teamwork among scientists and physicians to advance research, enhance patient care for genetic conditions.
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Thrilled to share that UCLA received a $29M gift to establish a center within the Institute for Precision Health (IPH). which will enable Scientists & physicians to work side by side to examine the role of genetics in disease and develop therapies that improve patientsā lives.
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Don't forget to join us for the Spring 2021 Seminar Series today at noon! Speaker is Daniel Geschwind, MD, PhD, from @UCLA. Here's the Zoom webinar link: https://t.co/jFzBpqmzHP
#WashUGen @GeschwindLab
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@UCLAHealth @GeschwindLab Making Sense of Sequencing: Exome Sequencing Analysis and What's Next. Listen to it here: https://t.co/R4xem2wSW0 Episode also available on @ApplePodcasts: https://t.co/vvIr3KpLhS
#geneexpression #genetics #genomics #sequencing #Findinggeniuspodcast
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Now out! From @GeschwindLab @UCLA : Abnormal social and repetitive behaviors and elevated striatal dopamine, a molecular hallmark of human psychosis, in a Maternal Immune activation non-human primate model
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Proud and excited to share our work on multi-omic integration in Autism! 1/4 https://t.co/nbSFz3ET06
nature.com
Nature Communications - Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions with repetitive and restrictive behaviours. Here the authors...
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My commentary on integrative genomics for the interpretation of genetic loci implicated in neurodevelopmental disorders is out today in @BiologicalPsyc1!! I had a lot of fun writing this and reflecting on all that Iāve learned from the great @GeschwindLab
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