
Tau Center Without Walls (CWOW)
@tauCWOW
Followers
119
Following
63
Media
2
Statuses
14
Using multiomics & functional genomics #CRISPR screens to study gene expression leading to novel therapeutic targets for treatment of #tauopathies
Joined May 2022
RT @MartinUCSF: Tenure-track faculty search of the @Ucsf_Biochem.Department is open for applications! . We are looking for creative, innov….
0
100
0
RT @MartinUCSF: Now out in @NatureSMB:. DELE1 oligomerization promotes integrated stress response activation . Work led by @_JieYang @Lande….
0
4
0
RT @FTDcwow: mutations in α-synuclein, TDP-43 and tau, oh my! Congratulations on the published work! 🥳 #ftdcwow #scienceatwork @AimeeKaoLab….
pubmed.ncbi.nlm.nih.gov
Together, this study provides evidence that pathogenic mutations in the N-terminal domain of α-synuclein (G51D, A53T), low complexity domain of TDP-43 (A315T, Q331K, M337V) and R1 and R2 domains of...
0
4
0
RT @MartinUCSF: Learning to control microglia using CRISPR. Thank you @NIH for supporting our work .(first author @DraegerNina, collaborati….
nih.gov
Researchers used CRISPR tools to identify genes controlling cells in the brain called microglia, which are involved in Alzheimer’s disease and other brain disorders.
0
8
0
RT @SinaiGenetics: Multiple tenure-track or tenured faculty positions at the Assistant, Associate, or Full Professor levels in Computationa….
0
15
0
RT @GeschwindLab: Our latest publication led by Yonatan Cooper identifying new dementia risk genes using MPRAs to screen noncoding GWAS var….
science.org
High-throughput functional analysis reveals cell-type-specific regulatory networks that mediate genetic risk for dementia.
0
25
0
RT @SinaiBrain: Just 2⃣ days left to submit your #MSNseminars applications! Senior postdocs in ALL fields related to #neuro are invited to….
0
16
0
RT @MartinUCSF: Check out this great Tweetorial by first author @DraegerNina to learn more about our paper "A CRISPRi/a platform in iPSC-de….
0
5
0
RT @MartinUCSF: Yay - Our paper is out in @NatureNeuro today:. A #CRISPR i/a platform in iPSC-derived human #microglia uncovers regulators….
nature.com
Nature Neuroscience - Dräger et al. establish a rapid, scalable platform for iPSC-derived microglia. CRISPRi/a screens uncover roles of disease-associated genes in phagocytosis, and regulators...
0
72
0
RT @MartinUCSF: Excited that we could contribute to this work led by @MarcoJost_ & @JswLab: . Maximizing CRISPRi efficacy and accessib….
biorxiv.org
CRISPR interference (CRISPRi) enables programmable, reversible, and titratable repression of gene expression (knockdown) in mammalian cells. Initial CRISPRi-mediated genetic screens have showcased...
0
8
0
RT @SinaiGenetics: ✴️Open Postdoc Position✴️The Goate lab concentrates on identifying human genetic variants associated w/AD & dissecting t….
0
11
0
Projects led by our PIs will use multiomics & functional genomics #CRISPR screens to understand molecular & cellular differences in gene expression & cell function due to H1/H2 haplotype inversion leading to new therapeutic targets for treating tauopathies
1
9
61
#Tau CWOW is a multi-site, interdisciplinary center connecting multiple levels of function: genotype, chromatin structure, RNA expression & splicing, and protein & cell biological consequences to elucidate mechanisms of tauopathies, funded by @NINDSnews
0
2
5