Colm O'Rourke
@ColmJJORourke
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Translational (epi)genomics in chemoresistance & metastasis of hepatobiliary cancers.
Joined November 2019
The NHS-Galleri trial results came out last Friday. 142,000 participants. 3 years. The most ambitious cancer screening trial ever run. The headlines: primary endpoint missed. That's a fact, and it matters. But I believe the headlines are missing the deeper story in these data –
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Excellent summary by @angRchen! Oncology fellows & junior faculty interested in clinical trials (including critical appraisal of trial data) should read this article that summarizes all the issues with the @NatureMedicine Immunotherapy time of day trial: https://t.co/M9ZjAj5M2A
Study on timing cancer treatments to the morning comes under fire
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Online now: Tumor microenvironment transcriptional activity enables robust stratification of chemotherapy response in triple-negative breast cancer
cell.com
Dai et al. demonstrate that tumor-specific total mRNA expression (TmS) outperforms existing classifications in stratifying triple-negative breast cancer chemotherapy responses across diverse popula...
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New online! Evolving roles of liquid biopsy in precision medicine for colorectal cancer: from single-gene analysis to broad genomic profiling
nature.com
Nature Reviews Clinical Oncology - Analysis of tumour tissue to guide the clinical management of patients with cancer poses several challenges. This Review outlines the potential of liquid...
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Online Now: Dissecting genetic and immune drivers of heterogeneous responses to neoadjuvant immunochemotherapy in gastric cancer https://t.co/r0bGnjJRwq
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🌟New Resource article Read about the pancancer landscape of cancer-specific cell-free DNA methylation and fragmentomic features from plasma samples from 1,294 patients ✒️Yong Zeng, @MatLupien, @PughLab, Housheng Hansen He & colleagues https://t.co/niJ57sU9N2
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PERSPECTIVE hot off the press @NatureCancer ! 'Setting higher standards for reports of microbial species in human cancers' 🔗 https://t.co/681K08lTYA ✒️By Steven Salzberg, Jacques Neefjes & Niranjan Nagarajan and co-authors #tumormicrobiome
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New online! Reconsidering adjuvant and perioperative immune-checkpoint inhibition: de-escalation, expansion and personalization
nature.com
Nature Reviews Clinical Oncology - Adjuvant therapy with anti-PD-L1 antibodies and other immune-checkpoint inhibitors (ICIs) is an established standard of care for many patients with surgically...
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TIGIT’s immuno-oncology teachings https://t.co/lgGz6Ipcwj Drug developers spent billions of dollars on clinical trials of TIGIT-blocking cancer immunotherapies, but have little to show for it. What went wrong?
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I wrote about the ambiguity in prognosis of a stage IV cancer diagnosis nowadays and the bravery our patients exhibit when they navigate that ambiguity every day. @NEJM
https://t.co/6AaujMRKJw
nejm.org
Survival in patients with cancer, affected by myriad factors, is notoriously difficult to predict. But while oncologists find it hard to communicate the uncertainty, patients are the ones who must ...
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Online Now: Chemotherapy triggers immune evasion by fostering LEPR+ Kupffer cell differentiation in liver metastases https://t.co/Ia759Mod6s
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Delighted to announce the 11th edition of our ImmunoSchool, focused on inflammation and aging and how modulation of inflammation can promote healthy longevity. Open to trainees and faculty. FREE & online, March 23–25. https://t.co/AYJX7PYVY8 Register:
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Modeling the evolutionary dynamics of clonal hematopoiesis -- @S_Marzban et al, Nature Genetics https://t.co/ZDzi6BCqGW
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Preview @ImmunityCP by @ajaeger40 TCRAFT: A Rosetta Stone for T cell receptors https://t.co/2nkCZEjvWp on @MEBirnbaum
https://t.co/VLF4LNMSWm
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Radiation as an immune modulator: mechanisms and implications for combination with immunotherapy | Nature Reviews Cancer
nature.com
Nature Reviews Cancer - Radiation therapy induces immune responses both systemically and within the tumour microenvironment. In this Review, Darragh and Karam present preclinical and clinical...
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The ageing immune system as a driver of systemic ageing
nature.com
Nature Reviews Immunology - Ageing of the immune system is now realized to drive systemic ageing, and there is interest in targeting immune ageing in order to promote healthy ageing. Here, the...
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🔬As neoadjuvant therapy expands, consistent pathologic response scoring is critical. 🆕 consensus guidelines establish a single pan-tumor system—with strong reproducibility (ICC >0.86)—to guide clinical care & research. 📖 Published in @Annals_Oncology 🔗 https://t.co/r2FY8JkqFC
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🧬Functional liver genomics in cancer cachexia (@CellCellPress)! https://t.co/xOe64f1VFb ☝🏼Tumor presence reprograms the liver transcriptome & epigenome 💥REV-ERBα emerges as a key regulator of hepatic remodeling 🎯Hepatocyte-specific REV-ERBα restoration → reduced peripheral
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🔥now fully published🔥 Clinical practice and implications of biomarker testing in biliary tract cancer: An observational study @JHEP_Reports
https://t.co/AGLiaNu63m 👉Our findings reinforce the value of targeted treatments and underscore the predictive and prognostic
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