Yi Xiao
@yixiaobio
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NCI K99 fellow in the McBrayer lab @CRI_UTSW | PhD in Biochemistry @MPI_MolGen #cancer_metabolism
Dallas, TX
Joined April 2010
My postdoc preprint is online now! We revealed GSX2 as a target of mutant IDH in glioma. Check full text below.
Mutant IDH silences GSX2 to reprogram neural progenitor cell fate and promote gliomagenesis https://t.co/ChSlnKkMTG
#biorxiv_cancer
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Happy 103rd birthday to theoretical physicist Chen Ning Yang (楊振寧). Yang shared the 1957 #NobelPrize in Physics with Tsung Dao Lee for investigating the parity laws, which led to discoveries regarding the elementary particles. Learn more: https://t.co/P0yJroukCb
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Excited to share another piece of my postdoc work, together with colleagues, we revealed an unappreciated signaling metabolite that stimulates neuronal activity in the glioma microenvironment and promotes glioma growth!
Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth https://t.co/6PJ2BzTuri
#biorxiv_cancer
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Today's #MondayMotivation is courtesy CRI's McBrayer Lab: Congrats @milan95 for successfully defending your dissertation! Dr. Savani's family and lab mates joined to celebrate. Next steps: publishing his #research & finishing his M.D. @UTSWMedCenter 🎉 #relentlessdiscovery
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We report a new role for HIF in the regulation of endogenous retroviruses! It was a big collaborative effort to explore the HIF-mediated transcription, expression, and HLA presentation of ERVs in kidney cancer and leveraging them for immunotherapy https://t.co/0Qpox9xWG2
cell.com
An upregulation of the HIF2 transcription factor, which is a hallmark of the most common form of human kidney cancer, drives the expression of multiple relatively intact endogenous retroviruses,...
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Another great day for #relentlessdiscovery & #CancerResearch: @SamMcBrayer received $1.19M to study developmental origins of IDH-mutant glioma in adolescents & @M_Agathocleous received $900K to study the role of glutathione in leukemia development from @CPRITTexas.
BREAKING NEWS: #CPRIT approved $68 million in grants to advance the state’s fight against cancer, including CPRIT Scholar recruitment awards, core facility support and clinical trial funding. #TexansConquerCancer READ: https://t.co/TuLZkccxiF
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Congratulations to @rumya_r @mircoscopy @DStrebinger @blake_lash @cyrusbiotech and colleagues on an exciting study combining AI and protein engineering to minimize the immunogenicity of Cas9 and Cas12a nucleases. These approaches have the potential to improve the safety and
1/ Thrilled to share an advancement in gene therapy from my PhD in @NatureComms! We've developed a new approach to reduce immune responses while maintaining efficiency—paving the way for safer, more effective therapies. Big thanks to @zhangf & @mircoscopy! https://t.co/eXZkpgiMXq
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Join us! My lab @UMassChan is seeking postdocs and research associates who are passionate about how changes in metabolism and epigenetics contribute to cancer development and immune system evasion. DM me for a chat and apply at https://t.co/VlYVMhYDVD (postdoc position)
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Collab🚨: CRI's McBrayer Lab contributed to a discovery published in @ScienceMagazine from @MangusoLab & Bardeesy Lab at @MGHCancerCenter that defines a new #cancer-causing mechanism associated with IDH1 mutations (the most commonly mutated metabolic gene across cancers). From
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New in @sciencemagazine! Our study reveals how mutant IDH1 inhibition activates tumor immunity by inducing dsDNA sensing. Read more: https://t.co/LrtJCwUOh5
#CancerResearch #Cholangiocarcinoma #IDH1 1/n
science.org
Isocitrate dehydrogenase 1 (IDH1) is the most commonly mutated metabolic gene across human cancers. Mutant IDH1 (mIDH1) generates the oncometabolite (R)-2-hydroxyglutarate, disrupting enzymes...
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OUT NOW in @Cell_Metabolism: CRI's @RJDLab, Dr. Zheng Wu & colleagues have have identified a new way to disrupt lung cancer growth. Read more:
cri.utsw.edu
Scientists have identified a new way to disrupt lung cancer growth in research from Children’s Medical Center Research Institute at UT Southwestern (CRI) published in Cell Metabolism. Their work...
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Congrats Xun and @MishraLab! Beautiful study, very happy to be able to contribute!
OUT NOW in @ScienceMagazine: @MishraLab, Dr. Xun Wang & colleagues have discovered a metabolic inflexibility in the liver that demonstrates one way regenerative cells root out damage. Read more: https://t.co/wz9oyTWBiK
#relentlessdiscovery
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MultiRNAflow: integrated analysis of temporal RNA-seq data with multiple biological conditions https://t.co/HzcLljp1T9
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We are 60 years young and look forward to the next 60 years of molecular genetics at@MaxPlanckPress! We are celebrating with a scientific symposium and a ceremony on 30/31 May. Celebrate with us and register by April 30! Please share! #MPIMG60years
https://t.co/7oD9TZYXO2
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Gliomas are among the most lethal and treatment-resistant human cancers. Listen to Sam McBrayer, an Assistant Professor at CRI, share how he and his lab are studying the way metabolism controls cell fate and cell function in the setting of #BrainCancer.
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Tracking cell-type-specific temporal dynamics in human and mouse brains
cell.com
A comprehensive view of single-cell transcriptome and chromatin accessibility dynamics of brain newborn cells provides insights into aging-associated shifts in cell-type-specific proliferation and...
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Excited that veloVI is out @naturemethods! Led by @adamgayoso & @PhilippWeiler7 w awesome @YosefLab, we combine deep generative modeling with a mechanistic single-cell transcriptional model for better RNA velocity analysis with uncertainty quantification. https://t.co/EaBpcqwexi
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RNA polymerase II associates with active genes during DNA replication
nature.com
Nature - Protein complexes containing RNA polymerase II and immature RNA are associated with active genes immediately after replication, suggesting that transmission of active transcriptional...
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Hey #sciencetwitter #mito #cancer ppl - pls RT - we've got two posts open in @mito_oncogene lab @CRUK_BI @UofGCancerSci for postdoc fellows! One computational one wet lab - something for everyone :) check out https://t.co/Qy34IEDPWf & https://t.co/UUqMYo1gAV for more info. 👍🙂
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A short take on how computational approaches leverage multimodal single cell (RNA+ATAC) for inference of regulatory networks and a brief review of recent ground-breaking work by Dictys, SCENIC+ and MIRA by @lucapinello @steinaerts @CistromeDB et al. https://t.co/uf1KFUK9qB
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