Payam A. Gammage
@mito_oncogene
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Group Leader @CRUK_SI . Mitochondrial genetics, genome engineering, cancer metabolism. Lab supported by CRUK, ERC & NCI. EMBO 'Young' Investigator.
Glasgow, Scotland
Joined February 2019
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Pinned Tweet
And now the final version
@NatureCancer
! 🥳
Some updates... 1/6
tldr; mtDNA mutations, found in ~50% of all cancers, are immunomodulatory - we can mimic the effect to make non-mtDNA mutant cancer sensitive to immunotherapy drugs.
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Proud to present the very first paper from Mitochondrial Oncogenetics
@CRUK_BI
in collaboration with the fantastic
@EdReznik
@alexgorelick
@sloan_kettering
@NatMetabolism
TL;DR - mtDNA mutations in cancer matter. Quite a lot. Passengers? On yer bike. 1/9
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A BIG thank you to
@ERC_Research
for supporting my group
@CRUK_BI
@UofGCancerSci
with an ERC Starting Grant! I’m humbled by the vote of confidence. For those interested in PhD or Postdoc positions aiming to unravel the mystery of
#mtdna
mutations in
#cancer
, watch this space… 😊
🎉ERC Starting Grant competition results are out!
Over €619 million for the best ideas of young leading researchers - and the 1️⃣st set of grants awarded under 🇪🇺
@HorizonEU
.
Find out who, where and why 👉
#EUfunded
#FrontierResearch
#ERCStG
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Genuinely blown away by the news I’ll be joining the latest crop of EMBO Young Investigators! A big thank you to everyone in our lab, collaborators, colleagues and funders - wouldn’t have happened without you 🙏
@CRUK_SI
@CRUKresearch
@UofGMVLS
@theNCI
@ERC_Research
Congratulations to the 26 new Young Investigators joining our network of 700+ current and former awardees – Welcome! 👏
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Super exciting news to start our year:
@EdReznik
from
@MSKCancerCenter
and us lot
@CRUK_BI
are making it official… with our first joint grant! An NIH MERIT (R37) award no less - thank you
@theNCI
for the vote of confidence. 7 years of transatlantic team science, here we come!
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Hey Twitter - please RT 🙏- thanks to
@ERC_Research
, the Mitochondrial Oncogenetics Lab
@CRUK_BI
@UofGCancerSci
is expanding! We’re looking for a permanent, senior member of the lab (Associate Scientist) to broaden and manage this expansion 1/4
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Hey everyone - Pls RT - we’ve got a great position open for a talented postdoc scientist to join us
@CRUK_BI
@UofGCancerSci
to study the impact of tumour mtDNA mutations on mitochondrial protein synthesis! Interested? Just get in touch🙂
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For those interested in assessing mtDNA mutation-mediated metabolic dysfunction in cancer cells and beyond, mTUNE cell lines derived in our lab using
#mtZFNs
are now available on collaborative or commercial terms through Ximbio.
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Dear
#ScienceTwitter
- Pls retweet - our lab is growing! There will be 3 postdoc jobs up in the next month, & we’re open to all sorts! There are computational, metabolic, functional genomic & in vivo projects - whatever you’re into, if you like
@mitojobs
pls get in touch! 😊
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Pls RT - we've got an exciting opening in our lab for a Postdoctoral Scientist to study the role of mtDNA mutations in tumour initiation and progression using unique in vivo models - if this sounds interesting please get in touch!
@CRUK_BI
@UofGCancerSci
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A little delayed with all the celebrating 🥳 but I want to offer my congratulations to
@mahnooorm
on her successful PhD viva
@CRUK_SI
earlier this week! Hard to quantify just how much she has accomplished and grown as a scientist in the last four years. Chapeau Mahnoor!🎩
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A big welcome to our new postdoctoral scientist, Andrew Shaw, and PhD student, Mahnoor Mahmood. Both of them will be working on big questions/challenges of mtDNA biology in cancer and mitochondrial genome engineering. Thumbs up if you’re excited to be
@CRUK_BI
!
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#happychristmas
#happylab
#happypeoplemightfinallyunderstandmytshirt
@CRUK_BI
@mahnooorm
@Eli_Tolla
@CatarinaMCor
@TaitMulder
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Looking for a fully funded PhD scholarship in cancer genetics & metabolism? Boy, do
@owen_sansom
& I have the thing for you! tl;dr mtDNA mutations are context-dependent drivers of cancer - but nobody knows how/why. Want to help find out? drop us a line 🙂
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Just out - an update on the state of the art and the road towards the clinic for mitochondrial genome engineering tools. A big thank you to all involved!
@mito_gene
@CRUK_BI
@MRC_MBU
@MitoResearch
@helsinkiuni
@CRUKGlasgow
@UofGCancerSci
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Just back from our first lab retreat at the beautiful Loch Lomond - science, sunshine, Scotland. What more can you ask for! Big thank you
@TaitMulder
for pulling it together. Question now is, where are we going next year…? 😉
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Hey
#sciencetwitter
#mito
#cancer
ppl - pls RT - we've got two posts open in
@mito_oncogene
lab
@CRUK_BI
@UofGCancerSci
for postdoc fellows! One computational one wet lab - something for everyone :) check out & for more info. 👍🙂
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Just following up on our recent paper describing the role of recurrent mtDNA mutation in cancer - here are a couple of pieces, from
@CRUKresearch
and
@NatureCancer
, for the non-expert audience:
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If being part of a fun & friendly team doing exciting work at a leading cancer research institute sounds good to you, please get in touch! 😊
Payam Gammage's (
@mito_oncogene
) lab is looking for a Senior Scientific Officer to join their team looking at mitochondrial DNA mutations in cancer
👉Find out more and apply here:
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Important Scientific Update: there is a pot of gold in the
@CRUK_BI
bike shed. On your marks, get set….go!
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What a day in the lab - a big day of expts and that sunset (including some successful cloning by me!
#stillgotit
)
@CRUK_BI
#whosaysscotlanddoesnthaveitall
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And what better way to celebrate all the recent good news than getting out as a lab (in Edinburgh 😱)
#R27
@mahnooorm
@CatarinaMCor
@TaitMulder
@PexiMexi
et al
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Them: ‘How could you justify getting that projector in your living room - you’re just playing Mario Kart insanely big aren’t you 😉’
Me: ‘No really, it’s for lab meetings….!’
@mahnooorm
@Eli_Tolla
@CatarinaMCor
et al
@CRUK_BI
#R27
#Morgansfinallabmeeting
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If you want to spend your PhD
@CRUK_BI
working on the interplay of mitochondrial biology and cancer immunology at a world class cancer research institute, go check out our joint project with
@Robertslab1
on offer through the UofG MRC DTP!
@UofGMVLS
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Sharing this picture I just found in my phone as it’s
#tbt
- just over a week ago, after a great couple of days together
@CRUK_BI
#mitomeetglasgow
@auroradevea
@rhodophila
@tennantlab
@LabPrudent
@KoryLab
@LucasBSullivan
- we’ve definitely got to do it again! 😊
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Some light weekend reading for those interested 😉. What we at
@CRUK_BI
&
@MSKCancerCenter
think about mtDNA mutations in cancer, the history of the field, and future directions.
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Dear
#sciencetwitter
friends - please retweet - the first of our promised
@mitojobs
, a 6 year postdoc position hosted by yours truly
@CRUK_BI
and
@EdReznik
@MSKCancerCenter
#mitochondria
#CancerResearch
1/3
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Pre-print alert! In collaboration with the brilliant
@alexgorelick
,
@EdReznik
& colleagues, we're very proud to present:
Respiratory Complex and Tissue Lineage Drive Mutational Patterns in the Tumor Mitochondrial Genome
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Big congratulations to the winner of the Problems in the Powerhouse: Mitochondrial Dysfunction in Cancer FEBS Molecular Oncology poster prize, Ross Eaglesfield!
#mitomeetglasgow
@KostasTokatlid
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eternal kudos to anyone who can make a coherent scientific narrative from what is currently on my whiteboard 😂
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And a very warm welcome it is, thank you!
We are sending a warm welcome to Payam Gammage who recently joined the Beatson Institute to start his Mitochondrial Oncogenetics group
@mito_oncogene
Find out more:
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We’re looking for a postdoctoral scientist to join our team working on an exciting project looking at the role of mitochondrial DNA mutations in cancer. Please share/RT or get in touch with me directly for more info!
📌 Are you interested in mtDNA and Cancer?
We are looking for Postdoc to join
@mito_oncogene
lab to study the impact of mtDNA mutations on tumour biology.
#AcademicJobs
#postdocjobs
⏰ Apply by 22nd October
More info here:
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Just under 1 week to go - if you're interested to discover what mtDNA mutations are doing in the ~70% of cancers they pop up in, get in touch!
We’re looking for a postdoctoral scientist to join our team working on an exciting project looking at the role of mitochondrial DNA mutations in cancer. Please share/RT or get in touch with me directly for more info!
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Definitely a
#proudpi
moment!
#mahnoorhatesbraf
What a great talk by Mahnoor on mtDNA mutations and metabolism in melanoma on the closing session for the 1st day of
#MitoMeetGlasgow
! I’ve learned so much from
@mahnooorm
these first few months since joining
@mito_oncogene
lab, super inspiring to hear about her exciting results!
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New kit just landed in the Mitochondrial Oncogenetics Lab - watch this space!
#genegun
#needtoreadtheriskassement
#mahnoorlookstoohappy
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If you’d like a little more discussion of the background and future directions resulting from our recent collaborative work with the
@EdReznik
lab - check this out 👍
Mitochondria are well known to be implicated in cancer, but very little is known about the role of mitochondrial DNA (mtDNA) in the disease. Dr Payam Gammage from
@CRUK_BI
thinks this is set to change. Read more: 1/3
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Just 3 days left to apply! Come join us and work at the fascinating intersection of mitochondrial genetics, metabolism and tumour biology at an amazing cancer research institute
@CRUK_BI
in beautiful
#Scotland
🏴
Hey everyone - Pls RT - we’ve got a great position open for a talented postdoc scientist to join us
@CRUK_BI
@UofGCancerSci
to study the impact of tumour mtDNA mutations on mitochondrial protein synthesis! Interested? Just get in touch🙂
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Are you passionate about understanding the role of mitochondrial dysfunction in cancer? We are a small, young and dynamic group working to discover more about these fascinating organelles, and we're hoping to find a permanent staff scientist to join in!
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Really proud of ours and
@FrezzaLab
’s recent review on mtDNA mutations in cancer being recognised by
@F1000Prime
! Hope it continues to be of use as this new/old field re-emerges
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connecting flight travel anxiety level 100: unlocked.
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Not quite out of date yet ;)
Mitochondrial DNA: the overlooked oncogenome?
Read the 2019 review from Payam Gammage and
@FrezzaLab
, part of our
#Cancer
#Metabolism
series:
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Dear
@GOVUK
- please can you stop trying to instigate the next phase of post-Brexit
#UKbraindrain
. Time is running out for you to retain some of the best scientists the UK can find!
#erc
#horizoneurope
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Hi all - happy to have joined the tweetosphere! First up is an exciting opening for a keen postdoctoral scientist to work on the role of mtDNA mutations in cancer:
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Embarrassingly accurate 😂
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When months of tenacity and troubleshooting finally pays off (twice) just as you’re heading off for Christmas break!
#scienceaintsobad
#workhardplayhard
#earlychristmaspresents
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What a cool animation - a bit unrepresentative in terms of the kinetics (relative rates of electron transfer, Q diffusion and proton translocation) but a nice educational aid for those who want to see C1 in action.
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It’s true! If you want to be part of our mission to understand the role prevalent
#mtDNA
mutations play in
#cancer
#metabolism
- apply below! 😊
Cutting-edge PhD studentship available with
@mito_oncogene
@owen_sansom
@CRUK_BI
looking at the impact of mitochondrial DNA mutations on cancer metabolism. To apply:
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Busy day on twitter here - pls RT - we are looking to recruit a talented, motivated Senior Scientific Officer (permanent staff scientist) to support the group + work on the role of mtDNA in cancer, here
@CRUK_BI
. Please see ad/get in touch if interested!
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An important first step into the unknown for the field of Mitochondrial Oncogenetics. Congratulations
@LauraGreaves81
@owen_sansom
et al!
Delighted to share our new paper in
@NatureCancer
which was at least 7 years in the making! Such a brilliant team effort, many thanks to all involved.
@JuliaCWhitehall
@DrPerscitus
@JLeslieScience
@AngPH09
@ndperkins
@Heer_Lab
@owen_sansom
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Making it happen behind the curtain, we’re very grateful to have Kate! 😊
From International Day of Women and Girls in Science
#IDWGS2021
to International Women’s day
#IWD2021
, we introduce you to some of the
#InspiringWomen
@CRUK_BI
.
Meet
@KSchraut
, one of the Project Coordinators at the Institute.
#WomenInScience
#WomenInSTEM
#IWDGS
#IWD
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Just landed
@CRUK_BI
- droplet digital PCR - for those of us who *really* want to know our copy numbers (and probably some other, non-mitochondrial stuff...)!
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Happy new year Twitter - if what is left of my New Year’s Eve dinner is anything to go by 2022 is looking to be good one! Cheers! 👍
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Beautiful work, and a major outstanding question of mitochondrial protein synthesis put to bed. Congratulations to all involved
@A_Amunts
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Undeniable, and not just in the USA. UK academy needs to wake up to its increasingly uncompetitive and unsustainable offering at all levels of the scientific career ladder
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A little treat for all the Glasgow mitochondriacs - please RT - very pleased to announce that we will be hosting Distinguished Speaker Dr Richard Youle for a seminar at 12:00 on Monday 30th September
@CRUK_BI
@CRUKGlasgow
- get it in your calendar!
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Fascinating images and observations! Excited to see what is discovered as the full relevance to organelle biology is dissected.
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If you’re interested, or know someone who might be, please get in touch!
The
@mito_oncogene
lab
@CRUK_BI
is offering a permanent, senior research position - Associate Scientist.
A great opportunity for someone looking to develop academic independence under some direction and develop their own ideas.
Curious? Follow the 🧵👇
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Thank you! What a great visit 😊
Welcome to
#PayamGammage
@mito_oncogene
, our
#MitoClub
guest today at
@MPIAGE
Host:
#ThomasLanger
@langer_lab
@CECAD_
#crc1218
#mito
#mitortg
#mitochondria
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Really looking forward to having you here
@tommacvicar
- the
@CRUK_BI
mito takeover continues 😎
@MitosRUs
I’m so grateful for this amazing opportunity to start my research group
@CRUK_BI
. Can’t wait to get going in December!
Many thanks to the reviewers and to all who have supported me over the years. Looking forward to sharing more details very soon!
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@FrezzaLab
@ItaiYanai
I think it’s easy for PIs to forget just how uncertain their postdoc years actually were. We look back and see all the freedom and time spent on science which we no longer have and focus on the rosy parts while forgetting the difficult parts. All stages have challenges.
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It’s the last chance saloon for abstracts and registration tomorrow! 🤠
Ecstatic to announce our mitochondria and cancer meeting - Problems in the Powerhouse: Mitochondrial Dysfunction in Cancer, CRUK Beatson Institute, Oct 24/25 this year, please share widely - details, registration, abstract submission 👇
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Turns out the type of mtDNA mutation, not the sheer number of mutations, determines fitness and longevity in drosophila.
#mitogenomeengineering
serves up some answers, and a whole bunch more questions! Great paper and collaboration with the
@whitworth_lab
@MRC_MBU
Check out our new collaboration paper from
@whitworth_lab
with
@Erikafvb
@mito_gene
@mito_oncogene
and our group
@cam_mito
. mtDNA mutations quality and not quantity shapes phenotype.
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As ever - if you would like to read an engaging, amusing and lucid tweetorial about our recent paper,
@EdReznik
’s is the one to go for 🙏
There comes a time in a PIs life where they rip free of the chains that bind them, and simply say all the things they want to say about a great paper. So here we go, a new paper driven by
@mahnooorm
and led by
@mito_oncogene
and I: Prepare to be annoyed
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🚨Final call for abstracts and registration for Problems in the Powerhouse: Mitochondrial Dysfunction in Cancer - 24th/25th🚨
Fantastic programme of invited speakers, short talk and poster slots available - don't miss out!
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Great news for our Institute, and for science in Scotland 👍🏴
#InTheNews
: Scottish research to get a major boost, thanks to our largest ever investment in Scotland of up to £123m.
This will bolster Scotland as a global hub for research on a competitive world stage and help recruit talented researchers from around the globe.
Read more 👇
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This is an amazing development. Hats off - nanopore applications just getting better and better
Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing
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From International Day of Women and Girls in Science
#IDWGS2021
to International Women’s day
#IWD2021
, we introduce you to some of the
#InspiringWomen
here
@CRUK_BI
.
Meet
@mahnooorm
, one of the PhD students at the Institute.
#WomenInScience
#WomenInSTEM
#IWDGS
#IWD
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Idea for improving pace & quality of publishing: make it possible to submit the same paper to more than one journal. This would: 1) incentivise journals to work faster/more efficiently; 2) create market pressures to introduce e.g. paid for peer review; 3) speed + quality ⬆️ 1/2
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Come work with Ed! He’s great at trapeze AND immunology. Win-Win, right?!
Interested in dendritic cells and how they shuttle antigen to lymph nodes? We're looking for a senior scientific officer at the Beatson Institute.
Bonus points if you also are up for lab trapeze
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A milestone moment for bioenergetics. Congratulations
@SazanovL
The coupling mechanism of mammalian respiratory complex I
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This advice is the exact opposite of where I was at when I chose to do a PhD & I explicitly state this when I give career talks now. It’s gone pretty well for me academically since and I think there’s room for diversity in how people approach major career choices. My two cents.
1/ Why do I want to do a PhD?
✅ I enjoy research and see myself pursuing an academic career
✅ I want to develop expertise in critical thinking, coding, project management, writing
❌ It sounds cool
❌ I like the idea of becoming a ‘Dr.’
❌ I don’t know what else to do
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Cheque's in the post
@AnhHLe2702
;-)
Payam is the nicest PI ever and you get to work on super cool projects that really are at the forefront of modern cancer biology, AND the Beatson is just the best place to be, amazing facility and the nicest people. Cannot recommend enough!!!
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She also enables our group's ongoing 3D printing hobby/addiction! Hooray for Nikki!
From International Day of Women and Girls in Science
#IDWGS2021
to International Women’s day
#IWD2021
, we introduce you to some of the
#InspiringWomen
@CRUK_BI
.
Meet
@NikkiRPaul
, one of the Scientific Officers within
@BairBeatson
.
#WomenInScience
#WomenInSTEM
#IWDGS
#IWD
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Candid, lucid and valuable thoughts on scientific careers from someone who helped guide me along the path not so long ago. Well worth a read.
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This tweet is perfect
“Thanks everyone for comments on the draft, here it is revised with all your edits.”
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This question and the ensuing comments/answers have triggered me, big time 😂
Do you consider mitochondrial DNA to be part of a eukaryote's genome?
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I remember seeing this TED talk as an undergrad in the late noughties and suddenly realising exactly why I had so profoundly disliked my high school education. A great thinker, speaker, and an inspiration. Thanks for the confidence SKR. You'll be missed.
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Thanks
@CRUK_BI
- to anyone interested in our science, we’re looking forward to hearing from you!
The
@mito_oncogene
group is looking for a keen researcher to join them as a permanent Senior Scientific Officer to drive projects on the role of mitochondrial DNA in cancer.
Applications close on Fri 21st Feb:
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A pleasure to have been involved # in our own small way with this. A pretty fascinating discovery, all told. Bravo
@SarahPalmer17
Jim Norman lab
@MitosRUs
et al! 👍
Thanks so much to everyone who contributed to this story
@CRUK_BI
and beyond! it is fantastic to see it out for everyone to read at last.
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👌👌👌👌👌
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Thanks
@FrezzaLab
for a great collaborative review! Mitochondrial DNA: the overlooked oncogenome?
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Had been on the lookout for a new reference for mitochondrial RNA processing dynamics... What lovely work.
@fiddle
lab, iteratively providing the next high watermark in mito gene expression research since the mid 2010’s 👍
Another new preprint! “Regulatory principles of human mitochondrial gene expression revealed by kinetic analysis of the RNA life cycle.” Let us walk through a day in the life of a mitochondrial RNA.
@ErikMcshane
led this beautiful study. (1/n)
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Welcome Erika!
Delighted to welcome
@Erikafvb
from Cambridge
@MRC_MBU
to our group at
@UofGIMCSB
@UofGMVLS
. Erika will work on our
#MitoROS
@BBSRC
project in collaboration with
@ChemBioGlasgow
to uncover the mysteries of
#ROS
and
#mitochondria
#biogenesis
and function.
@mitowomen
rock!
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A great piece on our recent collaborative work. Thank you
@sloan_kettering
@alexgorelick
@EdReznik
#mitochondria
#somuchmorethanthepowerhouse
If there's one thing you remember from high school science class, it's probably that the
#mitochondria
is the powerhouse of the cell.
But MSK scientists have found that it may actually hold important overlooked clues about cancer.
@EdReznik
@NatMetabolism
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If you’d like to listen to a pun laden conversation ostensibly about PhD’s, but that is actually about dream jobs (WWE wrestler -
@immuno_ed
) and sandwich artistry, this should keep you entertained for an hour or so.
EPISODE TEN!!!!
Welcome Ed and Payam as our very first guests! They talk to us about their career, what a PhD is and advice for anyone wanting to do one. Enjoy lots of laughs and wisdom from our favourite scientists!
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Hey
@NatMetabolism
- I’ve got some surprising news for you 😂😉
Who is your Twitter twin? 👯
@mito_oncogene
=
@NatMetabolism
mito_oncogene and NatMetabolism are Twitter twins!
#twitterTwin
#toasteed
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