Luca Pinello
@lucapinello
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Computational methods for epigenetic, CRISPR genome editing and single-cell genomics. Associate Professor at MGH / Harvard Medical School. https://t.co/GouTKpGNR2
Boston
Joined June 2009
🎄 What’s the best gift under the tree for a computational biologist? 🎁 A new assay that refines our view of gene regulation: ACCESS-ATAC!. #Genomics #SingleCell.
(1/8) Excited to share our latest preprint introducing ACCESS-ATAC, a high-resolution approach to measure chromatin accessibility and transcription factor binding:
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RT @DrAnneCarpenter: Have $10M and want to cure some diseases?. It costs ~$1B to invent a new medicine…but $10M buys you Project Encore, to….
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RT @NikolayOskolkov: I am starting a computational lab at LIOS, Riga, Latvia, and going to recruit a few people. Please DM if you are inter….
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RT @drklly: I'm excited to share work on a research direction my team has been advancing: connecting machine learning derived genetic varia….
biorxiv.org
Genome-wide association studies (GWAS) have identified thousands of trait-associated loci. Prioritizing causal variants within these loci is critical for characterizing trait biology. Statistical...
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Excited to be at #ISMBECCB2025! I'll be presenting at RegSys on "Learning the Regulatory Genome by Destruction and Creation" (Thursday 3:15PM in Room 11BC). I'm looking forward to connecting with both new and old friends throughout the conference! 🧬 #CRISPR #Genomics #Diffusion
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This changed how I write. No context switching, no copying - just select, shortcut, done!.👉 Feedback welcome!.Thanks @AnthropicAI for MCP! .What will you build on your next rainy afternoon? 🌧️.
github.com
MCP-powered text editing system that integrates Claude - lucapinello/claude-text-editor
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Why it rocks:.File-based (no timeouts!).Desktop notifications.Auto-clipboard magic.Works with Claude Desktop.Open source (MIT). Built for macOS 14+ 🍎.
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Want Claude to channel Hemingway? Add emojis? Write formally?.Edit ~/.claude_text_editor/claude_prompt.txt.Make Claude YOUR personalized writing assistant! ✍️.The possibilities are endless. .
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Love the terminal? Add this to ~/.zshrc:.ce() {. if [ $# -eq 0 ]; then. pbpaste | ~/claude-text-editor/claude_text_client.py. else. printf '%s\n' "$*" | ~/claude-text-editor/claude_text_client.py. fi.}.Now type: ce Fix this ✨.
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Here's the killer feature. No text selected? It auto-grabs your clipboard!.Already copied something? Just hit the shortcut. Claude polishes it instantly. Smart defaults FTW! 🧠.
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Quick setup:.git clone cd claude-text-editor. /install.sh. Import shortcut → Assign ⌥⌘. in System Settings → Done! 🎯.
github.com
MCP-powered text editing system that integrates Claude - lucapinello/claude-text-editor
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The magic? Select text → Hit ⌥⌘. → Claude edits it → Auto-copies to clipboard! 📋.Works in Gmail, Slack, VS Code, Terminal - literally ANY app. It's like having Claude as your co-pilot, always ready. Built with @AnthropicAI's MCP protocol 🔧.
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🧵 It's raining outside, perfect for some vibe coding. ☔.So I built something cool with @AnthropicAI's Claude Desktop!.Introducing Claude Text Editor - edit ANY text, ANYWHERE on macOS with Claude's help. No more copy-paste gymnastics! 🚀.
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Great to see it finally out —such a fantastic collaboration with @BKleinstiver, @RachelSilvers11 and team!.
In @nature we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR-Cas9 enzymes, offering safer & more genome editing tools. 🧬🖥️.@RachelSilvers11 @CGM_MGH @MGH_RI @MassGeneralNews @harvardmed.
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RT @BKleinstiver: In @nature we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR-C….
nature.com
Nature - Combined high-throughput protein engineering with machine learning to curate libraries of CRISPR genome-editing enzymes with distinct genome targeting properties is described.
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RT @nevillesanjana: 🚨📰TWEETORIAL time📰🚨. Excited to share recent work from our lab on noncoding genomics 🔎🧬: High-resolution CRISPR mutagen….
nature.com
Nature Communications - The oncogene MYC plays a key role in cancer initiation and progression. Using thousands of CRISPR perturbations, the authors investigate regulators of MYC in six different...
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RT @Xiaojie_Qiu: We are thrilled to join the FutureHouse community, @SGRodriques @FutureHouseSF! We are seeking exceptional machine learnin….
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Check out @SherwoodLab's excellent thread and share your thoughts! We’d love your feedback and are excited to see ACCESS-ATAC adopted widely, inspiring new computational methods to harness the potential of this groundbreaking assay. Happy holidays! 🎄✨#ACCESSATAC #GeneRegulation.
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Thrilled to share this fantastic collaboration with the brilliant and creative @SherwoodLab. ACCESS-ATAC leverages Ddd enzymes to enhance chromatin accessibility resolution, unlocks allelic TF co-occupancy insights, and powers groundbreaking discoveries in gene regulation.
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Excited to be visiting @DukeU to share insights on computational methods for single-cell genomics and CRISPR genome editing! Thank you for hosting me @Wings7Spread! 🙏.
Happening this week with special guest @lucapinello! Check out for more information. We hope to see you all there 🧬.
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