Lucas Tafur
@structureltp
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Group Leader @CNIOstopcancer | Structural biologist & biochemist | (m)TOR, cell growth, nutrient signaling, metabolism | Personal account, opinions=own
Madrid, Spain
Joined September 2022
Happy to share our latest work, now on BioRxiv! Here, we determined the cryo-EM structure of the yeast SEAC (GATOR)-EGOC (Ragulator-Rag) supercomplex, providing new insights into the function of this amino acid-sensing hub. https://t.co/WGmSaUDty8
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So happy to see this paper of ours online. Special thanks to Ryan Montalvo and RJ for the true team work. https://t.co/MP596kN4i4
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Ozempic exists because scientists studied Gila monster saliva. The exact kind of basic research this Administration would have cut without hesitation. Breakthroughs like this happen only if we choose to fund science even if the outcome is impossible to see at the start.
“We’ll lose 125 million pounds by this time next year.” RFK Jr. says the new deal with GLP-1 drug companies will play a major role in helping Americans get healthier. “It’s going to have dramatic effects on human health in this country.”
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What a structure!
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La grasa corporal se comunica con otros órganos. @Gsabiolab de #CNIOStopCancer liderará un consorcio internacional que ha recibido una ayuda #ERCSyG de €10 Mio. para investigar cómo afecta a la salud el mal funcionamiento de la grasa. @ERC_Research https://t.co/XSpmGicYYX
cnio.es
La quinta parte de la población española tiene obesidad, una enfermedad que eleva el riesgo de cáncer, enfermedades cardiovasculares o diabetes. Hasta hace poco se ha asumido que ese riesgo deriva...
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This paper may win the 2025 Y-Axis shenanigans award 👇🏻
🚨23 years of PSA screening in @NEJM 🚨 👉ERSPC RCT of >162k patients 📅Median 23 year f/u PSA screening lead to... 📉 #prostatecancer mortality by 13% ✅1 death prevented for every 456 men invited for screening or 12 diagnosed w/ PCa 📉Risk of advanced PCa by 34% ⭐️Benefit
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In which folk become aware that it’s always been Opinion Based Medicine (OBM). It just depends on what that opinion is informed by: https://t.co/EvlajfNlcS
What @drjohnm sees is that doctors simply accept what guideline writers put into those colored boxes: Which would b fine if guidelines were written by neutral Martians free of dualities of interests. But that’s not the case https://t.co/1NXVwrypKb
@Coronary4front @gbiondizoccai
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@ConsumerReports nearly all the plant-based products we tested had elevated lead levels: vegan powders had 9x as much lead as dairy & 2x as much as beef dairy-based powders had the lowest levels, but half were still too contaminated for safe daily use how could this be? well...
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my latest investigation for @ConsumerReports is based on months of reporting and 60+ lab tests of leading protein supplements we found that most protein powders and shakes have more lead in one serving than our experts say is safe to have in a day — some by more than 10 times !
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Truly exciting work done in Roger’s group!
We’re looking for an enthusiastic postdoc to join our team. 😊 The project focuses on protein design and cryo-EM applied to cancer research. 🔬🧪 Position funded for 3 years. Please share 🙏 Job description and details (deadline: October 11th):
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Our new paper out in @TrendsMolecMed “Science captured by storytelling: the oxidative stress narrative” DOI:
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Genetic impairment of ketone body signalling is a prevalent contributor to human metabolic dysfunction https://t.co/fm0tpkFBKn Working with our great collaborators at Pfizer we have uncovered a common genetic contributor to metabolic ill health/
medrxiv.org
Emerging evidence that circulating levels of key metabolic intermediates are sensed by a range of G-Protein Coupled receptors (GPCRs) is providing critical new insights into the control of systemic...
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Long overdue
A big moment for biomedical research publishing: - HHMI preprint mandate. Starting January 1, 2026, Howard Hughes Medical Institute (HHMI) labs will be required to publish all original research articles that represent major contributions from their laboratories as both
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You don’t like your trial results. Just add a meta-analysis to the results. My take on @Sensible__Med
https://t.co/Ychg96v3Yd Cc @kaulcsmc
sensible-med.com
The Study of the Week shows you how an industry sponsored trial, which failed to deliver a win for its drug, can be saved. This is not a good thing.
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Amazing stuff as always from the Hornberger lab. As much as I love TOR, there are also many other things going on!
1/ Ever wondered how lifting weights makes muscles grow? 💪Our latest study reveals that mTORC1 doesn’t always hold the key. Full breakdown + preprint in this thread 👇 https://t.co/WqkBT4Cvwj
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Mutation-induced filaments of folded proteins are inert and non-toxic in a cellular system | Molecular Systems Biology https://t.co/Olt1PN8vGU.
embopress.org
imageimageProteins can be driven by mutations to self-assemble into agglomerates (composed of folded proteins) or aggregates (containing misfolded proteins). Agglomerates are dissolved when wild-type...
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🕰️ Is #aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our @NatureAging Perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵 https://t.co/XUHWiHhVAu
@schumacherbj @AlexeiMaklakov
nature.com
Nature Aging - Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair...
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@DanielJDrucker I think one issue is that we often conflate the causes of a disease with the reverse direction of effective therapies. I am sitting next to Roy now, I suppose I could ask him!
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Much needed for the community!
We present BinderFlow, a modular & automated pipeline that makes de novo protein binder design more accessible, efficient, and user-friendly. Preprint by @Nayimcete, Twitterless Carlos, @LlorcaLab, and myself: https://t.co/OElkbCkETT Open source code: https://t.co/GL07gSBCpe
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What if the food you eat every day is slowly damaging your health? We’re surrounded by so many diets and endless advice that is conflicting which leaves most of us confused. So I wanted to sit down with someone who has studied and lived it for their whole life. Dr Andrew
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An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells
nature.com
Nature Metabolism - Kaluba, Rogers et al. show that in cancer cells that can metabolize ketones, they may reroute them to produce cytosolic acetyl-CoA and support tumour growth.
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