Carter Brzezinski
@sp3intermediate
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Biocatalysis, Pharmacology, Swimming. @KFBChem Postdoc @WuestLab alumni (‘25) @KenyonCollege swammer & alumni (‘20) he / him / his 🇯🇵
Atlanta, GA
Joined September 2019
Excited to share that our paper in collaboration with the Rather lab (Emory VA), Grabowicz Lab (Emory Microbio), and Sieber lab (TUM) is out now in PNAS! This was a highly cross-disciplinary collaboration to understand a unique HTS hit’s antibiotic MOA.
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RT @hanzyduzit: Something a little different from our group. We designed a regeneration system for ATP(gamma)S, a reagent that normally cos….
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RT @TotalSynthesis: Convergent #TotalSynthesis of Erchinines A and B and Their C20 Epimers by Yong Sun Cho, Joseph P. Tuccinardi, and John….
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RT @JacobGeri1: I'm excited to share my lab's first preprint! It describes Affinity Map, a highly general method providing proteomic profil….
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RT @mccarson23: Excited to share our total synthesis of aporphine alkaloids! Inspired by biosynthesis, we use a non-natural intermolecular….
pubs.acs.org
Aporphine alkaloids are important natural products with uses ranging from traditional Chinese herbal medicine to modern clinical applications. These compounds are isolated from a variety of plants...
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RT @ObradorsCarla: Check out this new direct #CHfunctionalization method for fused azines at #ACScentralscience : broad, metal-free and pro….
pubs.acs.org
Direct manipulation of C–H bonds enclosed in complex scaffolds persists today as an elusive disconnection when aiming for high and predictable site-selectivity. Its development toward the late-stage...
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RT @NaOHBartfield: Our approach to the total synthesis of chartelline C, out now in JACS. Photochemistry and unique topology gave way to so….
pubs.acs.org
Chartellines are cytotoxic marine alkaloids that were isolated in the late 1980s. Their unique, heavily oxidized structures, comprising a spirocyclic β-lactam, a halogenated indolenine, a chloroena...
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Inspiring stuff from Davies group here at Emory. Induced fit in a rhodium catalyst (III —> TS-C4)!.
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Holy reduction potential!!! -3.9 vs SCE.
Efficient super-reducing organic photoredox catalysis with proton-coupled electron transfer mitigated back electron transfer | Science
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RT @MingjiDai: Check out this @NSF news featuring our work @J_A_C_S on phaeocaulisin A total synthesis and biological studies! Cheers @Emor….
nsf.gov
Chemists funded by the U.S. National Science Foundation have developed a new process to synthesize a plant-based compound that shows effectiveness against…
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RT @WuestLab: Drug repurposing! Proteomics! Fighting antimicrobial resistance! Let’s go! . Shout out to Carter (@sp3intermediate ) for spea….
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Special thanks to Franziska Elsen and the rest of the Sieber lab, who hosted me for a month in Munich to learn and perform these proteomic experiments (and take me hiking through the mountains of Germany!) Best learning / science experience of my whole life.
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Jen then demonstrated that OXA-23, one of the most common beta-lacatamases in hospital-acquired A baumannii infections, is an OM lipoprotein! Inhibition of lipoprotein trafficking causes OXA-23 mislocalization to the IM, explaining the observed difference in activity.
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This small molecule has improved antibiotic activity against OXA-23 beta lactamase expressing A. Baumannii compared to beta-lactam sensitive cells. Why?? To understand this, we used a photo-reactive probe to pinpoint that this molecule inhibits lipoprotein trafficking via LolF
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Wow! Small molecule, big MOA.
Happy to present our latest paper with @pottslab & @Amgen in @J_A_C_S by co-first authors @C_M_Zammit & Cory Nadel on the discovery of a direct-acting covalent destabilizing degrader of AR and the undruggable truncation variant of AR, AR-V7, in androgen-independent prostate
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RT @TotalSynthesis: Concise #Syntheses of Lycojapomine Alkaloids Enabled by Radical Dearomatization of a Pyrrole by Benjamin M. Gross and B….
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RT @NatureSynthesis: Now online & open access:. Article by Zibo Bai, Zikuan Wang, Thomas Hin-Fung Wong & Tobias Ritter @ritter_lab . Thiant….
nature.com
Nature Synthesis - The lack of stable and versatile bicyclo[1.1.1]pentyl reagents hinders their broader adoption as aryl bioisosteres in drug discovery. Now, a stable, bifunctional...
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Beautiful! Never seen an Trp N-H act as an H-bond donor like that!.
Structural Basis for Dehydrogenase/Reductase-Catalyzed Reductive Cyclization in Polycyclic Tetramate Macrolactam #Biosynthesis by Xiangqian Xie,Fan Li, Yanxin Mu, Mengyao Lu, Jie Luo, Haoxin Wang, Yuemao Shen, Liangcheng Du, Deyu Zhu, Yaoyao Li in @J_A_C_S
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RT @angew_chem: An Update: Enzymatic Synthesis for Industrial Applications (Uwe T. Bornscheuer and co-workers) #AngewandteReview #openacces….
onlinelibrary.wiley.com
Biocatalysis has become a sustainable and cost-competitive alternative to established chemical synthesis, enabling the enzyme-based production of not only commodity chemicals but (non-natural) amino...
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