Carter Brzezinski
@sp3intermediate
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Biocatalysis, Pharmacology, Swimming. @KFBChem Postdoc @WuestLab alumni (‘25) @KenyonCollege swammer & alumni (‘20) he / him / his 🇯🇵
Atlanta, GA
Joined September 2019
Check out @HJLChem and I’s recent report on using VHPO enzymes to prepare oxindoles and spiro-oxindoles! Excited to see this work out and help eliminate the need for hazardous halogenating reagents and harsh oxidants. Go team VHPO!
KFB Lab Alert: Our general biocatalytic platform for the oxidative rearrangement of indoles is now online at @ChemRxiv! Congratulations to @HJLChem and @sp3intermediate for leading this work with Sergio, Raina, Ana, Sophie, and John! https://t.co/7PMBifdyjJ
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Stereocontrolled #Synthesis of 8-Hydroxycurvularol, a Sesquiterpene with a Modified Trichothecene Skeleton by Johanna M. Masterson (@JohannaMasters2) and Erik J. Sorensen (@sorensen_group) at @PrincetonChem in @JOC_OL
https://t.co/0I8PBDfmk3
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Now online and open access: Article by Michael J. James & co-workers @UoMChemistry Reductive radical chain initiation through the thermal generation of carbon dioxide radical anion https://t.co/20MtHDWa2d
nature.com
Nature Synthesis - Radical chain initiation strategies are fundamental to the synthesis of small molecule drugs and macromolecular materials. Here a general, thermally driven and scalable method...
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Enantioselective #Synthesis of (+)-Auriculatol A by Jordan K. Thompson, Kala C. Youngblood, Yun Hao Shawn Teh, @ConnerFarley, Zhehao Zhang, Scott C. Virgil, and Sarah E. Reisman at @CaltechCCE
https://t.co/4x2WFgSGCs
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Excited to showcase my first first-author paper deposited on chemarxiv this morning! We propose using fundamental physical catalyst properties as features for ML prediction of nickel catalyst performance. Thanks to all those involved in this project.
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Huge congratulations to the Ackerman-Biegasiewicz team on their work entitled "Harnessing Spectral Fingerprints to Predict Nickel Catalyst Performance"! LETS GO! https://t.co/JzusnnQlQ4
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#TotalSynthesis of Annotinolide B via Sequential Quinoline Dearomatization by Bhawyanth Duvvuru and Myles W. Smith at @utswnews in @J_A_C_S
https://t.co/BcQuAmVsYL
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Congrats to Emilien, Maurus and Giorgia! Metal- and CO-Free Carbonylation of Alkyl Iodides @J_A_C_S. https://t.co/Q8DBosj4Wb
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Thrilled to share the first paper from our group at UCLA, online today in Science: “Biocatalytic, Asymmetric Radical Hydrogenation of Unactivated Alkenes” @uclachem @ScienceMagazine
https://t.co/YCtGp91kd2
science.org
Alkene hydrogenation is a cornerstone of chemical synthesis, yet enzymatic strategies remain limited to electron deficient substrates via hydride transfer. Using heme enzymes, we unlock a hydrogena...
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Congratulations to team Ackerman-Biegasiewicz on their awesome new study entitled "Elucidation of Mononuclear Fe Photocatalysts for Visible Light-Induced Bond Homolysis (VLIH)" now available @ChemRxiv! Super cool study! https://t.co/Giq7tAHP6K
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Happy to see the final version of this paper out! Congrats to Lauren Orr and Annika Page in our close collaboration with @Toste_Group and @NovartisScience on second gen acyl silane photoaffinity handles for chemoproteomic applications!
pubs.acs.org
Deconvolution of the protein targets of hit compounds from phenotypic screens, often conducted in live cells, is critical for understanding mechanism of action and identifying potentially hazardous...
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Pleased to share our @ChemCommun paper on the @totalsynthesis of Brevianamides X, Y & Z! 🌿A hydroxyproline-guided cascade reveals how oxidation timing directs X/Y divergence-bridging synthetic design and biosynthesis🌿. Congrats to all the authors! Link: https://t.co/P351cdDa38
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Check out our latest work on generation of quaternary stereocenters through asymmetric oxy-Cope rearrangement! Out now in @JOC_OL #OrgLett. Congratulations @GANESHKARAN16 @98Susanta @shubhamsnehil21 Find out more on https://t.co/kHo5K0lqKK
@IITKgp @modhumaji @ANRFIndia
pubs.acs.org
An asymmetric chemoselective allylation followed by an oxy-Cope rearrangement sequence is developed to efficiently synthesize chiral β-allylated ketoimines bearing quaternary stereocenters in...
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Check out our latest article in @J_A_C_S! We developed a new cascade reaction that combines alkylation, Heck carbopalladation, and C(sp3)–H annulation to generate cyclopropane or cyclobutane heterocycles. https://t.co/lhjkw1ytJA
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Bit of a shot in the dark, but has anyone ever prepared this nifty Mitsunobu reagent using the 40% in tol. solns of DEAD instead of the pure reagent? (This feels like a @ndchiappini question)
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CATNIP for the win! Read our newest work with the Gomes group- https://t.co/lILWdTxbVR
@Apatoneh @gabepgomes @daniil_boiko @AlisonNarayanUM
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Have a look at our perspective on asymmetric partial reductions of pyridines ⚗️🔭Congratulations to Ashlyn and Ben!!! 👏 https://t.co/uvXCMaqFaz
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Excited to showcase published version of our covalent destabilizing MYC degrader in @angew_chem that stereoselectively targets an IDR C203 in MYC! Congrats to Hannah Rosen and Kelvin Li & thanks to #TomMaimone, @NovartisScience & @TheMarkFdn!
onlinelibrary.wiley.com
This study reports stereoselective sulfinyl aziridine covalent ligands that directly degrade the oncogenic transcription factor MYC by engaging intrinsically disordered cysteine C203. Lead compound...
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Happy to see that two of our recent total syntheses are among the top three Most Read Articles @J_A_C_S; Among the top five, three are from Emory @EmoryChem @emorycollege @EmoryUniversity and four are total synthesis papers @TotalSynthesis! Cheers! https://t.co/o6cQqetTaZ
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