J Org Chem/Org Lett
@JOC_OL
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For those interested in not exploding, please read this
#JOC
editorial from Treitler and Leung
#BMSChemistry
featuring three cardinal rules for azide safety
14
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This year's recipient of the Organic Letters' Outstanding Publication of the Year Award is Prof. Ruben Martin, a Research Professor at ICIQ! Learn more about Prof. Martin and his award-winning publication:
@rmartinICIQ
25
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217
The
@JOC_OL
team is sad to hear of the passing of Harvard organic chemistry legend David Evans, (11 January 1941 - 29 April 2022)
@daddydog22
. We will share more details when available.
7
28
217
Everyone loses when we discard negative data, but what does it truly mean? Authors
@NSF_CCAS
@AstraZeneca
@MITChemE
@NDScience
describe four categories of reaction outcome we should all know about. Read all about it in
@JOC_OL
;
2
43
199
Cute "Cat-alysts" adorn our latest
#OL
cover. It 's more than just cats though, the research reports how strain-promoted cycloaddition enables two building blocks to be “threaded” without a catalyst or additives. See all the articles here:
@ACSPublications
3
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We at
@JOC_OL
are thrilled to announce Prof. Song Lin of Cornell University
@songlin_chem
has joined the
#OL
team as an Associate Editor! Watch for Prof. Lin to handle your Org. Lett. manuscripts on synthetic electrochemistry and electrocatalysis.
@ACSPublications
11
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184
– A collection of Introductory Appropriate Organic Chemistry Reactions. Check out this nice resource from
@denniscao
recently featured in The Journal of Chemical Education
0
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181
Expanding approaches to direct decarboxylative amination: The Direct Decarboxylative N-Alkylation of Azoles, Sulfonamides, Ureas, and Carbamates with Carboxylic Acids via Photoredox Catalysis.
1
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165
One more reason it's a big week at Org. Lett. ... drum roll please ... our next Editor-in-Chief will be Prof. Erick Carreira of ETH Zürich! Already an associate editor, Prof. Carreira will take the helm in Jan. Congratulations. Read the announcement here:
1
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153
Photochemical dearomative reduction of quinolines, in
#OrgLett
by M. Kevin Brown and coworkers
@SouvikA26351772
@KBrownLab
from Indiana University, Bloomington.
#Dearomatization
1
19
129
New in
#OL
, the attempted generation of 2-thiophyne led to the expected aryne-trapping product, but through a completely unexpected mechanism involving a novel ketocarbene intermediate. Appearances can be misleading! Learn more:
@ciqususc
@UniversidadeUSC
3
23
128
The latest
#OrgLett
issue is out, and this week we focus on what constitutes a sufficient and reasonable scope for an initial communication centered on a new synthetic method. Check out the Cover, Editorial, and first Letter--let's continue the discussion
0
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' Intramolecular Hydrogen-Bond Activation: Strategies, Benefits, and Influence in Catalysis'
One of the most popular papers in ACS Organic & Inorganic Au in 2022.
Find out why. Fully open access 👉
2
18
118
The latest safety note from
@JOC_OL
A Need for Caution in the Preparation and Application of Synthetically Versatile Aryl Diazonium Tetrafluoroborate Salts, by
@Ian_Fairlamb
and James Firth
@ChemistryatYork
. Please read carefully:
0
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Prof. Sunoj joins the JOC Editor Team! We are pleased to welcome Raghavan Sunoj from IIT Bombay
@sunojchemlab
as our newest Associate Editor--he may soon be handling your manuscript. Please send some good ones to get him started.
7
13
115
Retro Blast from the Past (2019): Our
#TOCoftheWeek
, and it’s not even in our journal: Student-Generated Digital Tutorials in an Introductory Organic Chemistry Course, a reminder by
@Teachforaliving
2
22
111
In
#JOrgChem
@Kirby_G_
,
@PrestatG
, and
@BerhalFarouk
now report an atom-economical iron-catalyzed oxyamination of alkenes. Hydroxylamines are used as both a nitrogen source and oxygen source. Check it out!
7
9
110
Check out in
#OL
how to use weak light (390 nm) to trigger the chemoselective radical functionalization of tryptophan-containing peptides. A photochemical strategy reported by the
@MelchiorreGroup
@ICIQchem
.
0
19
105
Another issue of
#JOrgChem
is out, and it is a special one: Modern Enantioselective Catalysis in Organic Chemistry (). A great collection of articles on the latest trends in the construction of chiral compounds. Please have a look, share with your friends.
0
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We are pleased to announce the Wilkerson-Hill group
@uncchemistry
is recipient of the 2021 Organic Letters Outstanding Publication of the Year Award! Learn more about
@SmwhLab
research and watch for the
@ACSorganic
symposium this fall!
@ACSPublications
11
15
102
Now out in
#OL
@JOC_OL
,
@PB_LAB_IITRopar
@Maajid_Majd
@debarshi1992
@iitrpr
@serbonline
report a site-selective electrochemical Ritter-type reaction of phenol for the direct & sustainable synthesis of
#Paracetamol
.
4
21
101
In light of recent global events, including for organic chemists a recently retracted editorial concerning our field, a commitment from
@JOC_OL
and
@Orgmet_ACS
…
1
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97
Fresh from France. A
#JOC
virtual issue on organic chemistry (), introduced by JOC Associate Editor Géraldine Masson
@ggmasson1
who describes the enduring tradition of French chemistry (). Please check it out.
3
31
97
Skrydstrup and co-workers have developed bench-stable tablets (COtabs) that can release CO by merely adding base. Glovebox techniques could be avoided by using COtabs
1
27
94
How Should I Think about Voltage? What Is Overpotential?
@Stahl_Lab
answers these and other burning questions in this
#JOC
Synopsis, part of our upcoming Special Issue on Electrochemistry. Now an ACS Editors' Choice selection. Please have a look:
0
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Azides have become protectable from click reactions. Can you believe it!
2
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91
JOC is excited to announce a new addition to our Associate Editor Team: Prof. Géraldine Masson of the CNRS Institut de Chimie des Substances. Prof. Masson may soon be handling your manuscript!
6
8
93
New in
#JOC
a Perspective on 19F-Prolines by
@MykhailiukChem
with disclosed structures that chemists "forgot" to make! Please check it out:
1
20
92
Congratulations to Naoki Oka on a new
#OL
publication reporting a valuable protective group for aryl boronic acids, Epin. Learn more here:
@JOC_OL
@sajikilab
@ikawa_takashi
0
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93
Check out first thioester synthesis using elemental sulfur (S8), in
#OL
from the Takemoto group (
@TakemotoLab
): Photocatalytic Activation of S8 Enabling a Three-Component Thioesteification ().
1
13
92
A group of Ukrainian authors (
@EnamineLdt
,
@KyivUniversity
@DrGregor2
) has discovered unusual chemical behavior for the Ruppert-Prakash reagent and imidazole derivatives, resulting in C–H difluoromethylation. Please have a look:
1
20
89
Sulfenamides are an often-ignored functional group due to their instability. A new computational study in
#JOrgChem
of the α-effect for S–N nucleophiles reveals that an unusual anomeric interaction may aid their stability. From
@vanvellergroup
,
0
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More superb chemistry from the
@EnamineLtd
team. This
#JOrgChem
Featured Article describes the synthesis and study of new fluorinated aliphatic diazirines of interest to photoaffinity labeling of biological targets. Please have a look:
2
17
87
Now out in
#JOC
:
@THansenChem
, Jasper Roozee,
@fmbickelhaupt
, and
@TrevorAHamlin
provide a unified framework to understand how solvation influences SN2 versus E2 competition. Part of an upcoming Special Issue on Solvation Effects. Check it out!
1
20
84
We at
@JOC_OL
are pleased to announce that
#OL
Associate Editor Pauline Chiu () will take the helm as Interim EIC as current EIC Erick Carreira transitions to lead
@J_A_C_S
. Stay tuned as the new Org. Lett. EIC search is under way!
@ACSPublications
3
12
87
An unprecedented olefination of a single C(sp3)–O Bond, performed by the Sartillo-Piscil group
@fergotico
. Please check it out in
#JOrgChem
0
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The first total synthesis of the antibacterial macrolide sorangiolide A, 28 years after its discovery. See the Letter from Goswami and colleagues:
1
19
86
A practically simple visible-light mediated alkylation of pyridine derivatives is reported by
@samilakhdar1
and colleagues. Check it out in
#OL
:
9
18
84
A new Virtual Symposium! Sponsored by
@ACSorganic
+
@RoySocChem
+
@SCIupdate
and highly recommended by
@JOC_OL
. Globally available on June 11. Featuring Oliver Ring
@RingSynthesis
and Sarah Reisman
@sarah_reisman
YouTube:
Zoom:
0
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Just out in
#JOrgChem
: "Merging Two Strained Carbocycles: Lewis Acid Catalyzed Remote Site-selective Friedel-Crafts Alkylation of in situ Generated β-Naphthol" by
@PB_LAB_IITRopar
,
@ArijitH80372271
&
@tanmay_kanji
. Check it out:
1
11
75
We at
@JOC_OL
are very pleased to announce that Prof. Marisa Kozlowski
@KozlowskiMarisa
of the University of Pennsylvania has been selected as the new Editor-in-Chief of Organic Letters! Learn more here: and watch for more to come.
@ACSPublications
0
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Drug Hunters! Explore and expand the potential of a ‘Silicon Switch Approach’ in medicinal chemistry. Check out the recent
#OrgLett
article by
@DSReddy_IIIM
@csiriict
on access to silicon-containing building blocks
0
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In the past decade, there's been a resurgence of interest in organic electrochemistry, leading to a boom in new synthetic methodologies, mechanistic understandings, and instruments. Check out this
#JOC
Special Issue to learn the latest
@ACSPublications
0
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78
Alkynes of heterocycles: New work from
@AnotherSmithLab
@ChemistryFsu
in
#OL
.
@FSUResearch
@FSUartssciences
@TotalSyntheses
@JOC_OL
. Please have a look:
0
11
78
'1,2-Radical Shifts in Photoinduced Synthetic Organic Transformations: A Guide to the Reactivity of Useful Radical Synthons'
One of the most popular papers in ACS Organic & Inorganic Au in 2022.
Find out why. Fully open access 👉
0
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77
Today in
#JOC
, Design and Synthesis of Visible-Light-Responsive Azobenzene Building Blocks for Chemical Biology, by Szymanski, Feringa, and colleagues. Our
#TOCoftheWeek
. Please have a look:
0
7
76
Fleeting strained intermediates in
#OL
.
@Garglab
reports silyl tosylate precursors to strained cyclic alkynes and alkenes.
@uclachem
@ucla
@uclanewsroom
@uclaphyssci
0
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77
For our part, we have been talking a lot about how many examples should be in an OL methods paper to establish scope. What do you think?
10-20 examples
1018
20-30 examples
666
30-40 examples
122
>40 examples
103
13
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78
Check out new radical carbene catalysis in OL from the Ohmiya group (
@OhmiyaLab
): N-Heterocyclic carbene catalysis enabling vicinal trichloromethylacylation of alkenes using tetrachloromethane and aldehydes
0
7
76
All in one pot by the correct choice of the oxidation state: Fast and efficient access to BOIMPY fluorophores, from
@WerzLab
@tuBraunschweig
. Please see the
#JOC
article:
2
7
75
Now recommended to carry out your chemical manipulations with a CIA agent — Sodium Hypophosphite — a Cheap, Innovative & Alternative agent for reductive amination. Find more in this
#OrgLett
new article from
@chusovgroup
0
12
75
A new strategy for racemization of tertiary and secondary alcohols using a boronic acid/oxalic acid cocatalytic system that proceeds via reversible C-O bond cleavage, demonstrated in
#JOC
by
@BoyceSynLab
@stef_mus
@Dr_JamesTaylor
@ADS_StAndrews
0
15
73
In the latest Perspective article in
#JOC
, a beautifully told story from
@BaranLabReads
about taxane natural products weaves in dimensions from biosynthesis, medicinal chemistry, and translational science. Take a break and read:
@ACSPublications
@JOC_OL
2
18
74
New in Org. Lett. from
@cootegroup
: Synthesis and applications of versatile bicyclic diazetidine products - read about it here:
0
17
72
An intriguing SN2-glycosylation triggered by frustrated ion-pair interactions in sterically hindered pyridinium salts reported by Kancharla
@pavankancharla
and coworkers
2
12
73
Natural Product Synthesis: The Endless Quest for Unreachable Perfection
A perspective from Nicolas Fay, Cyrille Kouklovsky, and Aurélien de la Torre
@psl_univ
@AuredelaTorre
🔓 Open access in ACS Organic & Inorganic 👉
0
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The fusion of
#photocatalysis
and
#noncovalent
interactions for synthesizing biaryl frameworks regioselectively from thiophenes and alkynes, in
#OrgLett
by
@VishalJyotiRoy1
@Jchakraborty061
and
@srrlab
@iitdelhi
@Indian_Science_
@chemistry_iitd
0
14
74
New in
#OL
@Schoenebeck_Lab
reports a selective and transition-metal-free formal C−H Germylation of Arenes and Styrenes, via dibenzothiophenium salts, using a robust and bench-stable Ge source PhMe2Si-GeR3. Please have a look:
0
6
71
Enlightened path to HIV-1 protease inhibitors:
@reiser_group
constructs cyclopentanonyl-fused ethers via a photocatalytic decarboxylative radical conjugate addition-elimination-oxa-Michael cascade. Please see the
#OL
article to learn more.
0
14
71
Exciting news from
@sundenlab
! 🧪 Discover how they're merging oxidants and carbenes in one hybrid catalyst for cutting-edge organocatalysis. See the work in
#OrgLett
. Many thanks to
@SaraBacaicoa
and Simon for their dedication and hard work!
#Carbenes
1
14
71
Demystifying the greater reactivity of hydrazine hydrate in asymmetric organocatalysis. Check out the new work in
#OrgLett
from the Ghorai group
@iiserbhopal
@chem_iiserb
1
15
72
Just out in
#OL
, urea ligands enable the Pd-catalyzed heteroannulation of bromophenols and 1,3-dienes to generate functionalized dihydrobenzofurans. Please see the new Letter from
@paradinelab
@URochesterChem
0
12
71
An efficient method to construct 4-aryl substituted β-carbolines from indole-2-methyl-α-aminoketones via a TMSOTf-promoted annulation reaction, reported in
#OrgLett
by Yang (
@JinMingYang3
), Wu, and coworkers. Please have a look:
1
7
70
The synthesis of chiral dipyrenoheteroles with exciting CD and CPL properties is reported in
#OrgLett
by the
@ChalifouxGroup
and their collaborators (Würthner, U Würzburg). Please have a look:
1
8
70
Oxidant-controlled divergent cyclizations to access either mavacurane (pleiocarpamine, talbotine) or akuammilane (strictamine) precursors from
@GVincentUPSUD
,
@MaximeJarret
,
@LaurentEvanno
,
@erwan_poupon
. Check it out in
#OL
:
1
15
68
Recent
@JOC_OL
paper from Bernard L. Feringa et al. on molecular switches and motors!
#Chemistry
#NobelPrize
0
71
69
The unconventional combined Lewis acid catalyzed chemo- and diastereoselective cascade annulation of enone-tethered cyclohexadienones, leading to functionalized halogenated bicyclic enones. See the
#OrgLett
results by
@RambabuChegondi
@csiriict
@CSIR_IND
0
10
69
New in
#JOC
@roizengroup
and
@DukeChemistry
shine some light on methods to access to N-aryl sulfamides by dual Ni/Ir catalysis. Read more here:
1
21
67
Congratulations to Amos Smith - 20 years as Editor-in-Chief at Organic Letters. What an accomplishment!!
1
8
67
New in
#OrgLett
@GharpureLab
demonstrates base-promoted synthesis of cyclic and spiro heterocyclic β-ketosulfones via hydroalkoxylation-initiated cascade of sulfone-tethered aryl alkynols
@sjgharpure
,
@DipakFartade
,
@Santoshknanda87
,
@Shipra_1997
1
21
67
OL Associate Editor Sarah Reisman
@sarah_reisman
@CaltechChem
is the first recipient of the Dr. Margaret Faul Award for Women in Chemistry by
@thiemechemistry
... for breaking new ground in the synthesis of natural products.
@JOC_OL
@acspublications
0
9
65
Just out in
#OL
the use of pentafluoropyridine to generate acyl fluorides from carboxylic acids and subsequently synthesize amides in a one-pot process by
@WDGBChem
and
@Cobb_Group
. Learn more here:
1
16
68
' Emerging Applications of Aryl Trifluoromethyl Diazoalkanes and Diazirines in Synthetic Transformations'
One of the most popular papers in ACS Organic & Inorganic Au in 2022.
Find out why. Fully open access 👉
0
8
67
We at
#OL
are pleased to announce John Monteith and Sophie Rousseaux as recipients of our Outstanding Article of the Year Award, for their work Ni-Catalyzed C(sp3)–O Arylation of α-Hydroxy Esters (). Learn more here:
@ACSPublications
8
10
67
New today from
#OL
, Synthesis of Noraugustamine and Development of an Oxidative Heck/aza-Wacker Cascade Cyclization, from
@sarah_reisman
and coworkers
@CaltechCCE
. Please have a look:
0
9
66