Thrilled to share the first paper from our group at UCLA, online today in Science: “Biocatalytic, Asymmetric Radical Hydrogenation of Unactivated Alkenes” @uclachem @ScienceMagazine https://t.co/YCtGp91kd2

Calling all #Bioinorganic folks in SoCal! The 2025 SoCal Bioinorganic Symposium is at UCLA on Nov 8th, 2025. The abstract deadline for a talk or poster has been extended to Nov 1st, 2025. We are looking forward to seeing you all! https://t.co/GiY0PBynRA

Many congratulations @athavale_s Excellent work. Congratulations to all the authors including former student of @Basker_IITK. Proud of you, @RajibM22 …..Work hard, there is no better way to taste the success! @UCLA @IITKanpur @Chemistry_IITK #proudmentor

This work builds on @pushingarrows pioneering cHAT chemistry, the broader field of MHAT catalysis, and the remarkable new-to-nature biocatalysis revolution inspired by @francesarnold. Great collaboration with @houk100 and @ShafaatLab Grateful to all who paved the way.

Given the vast diversity of heme proteins, the simplicity of activating BioHAT via a single cysteine mutation, and the power of directed evolution, we envision cultivating stereoselective hydrogenation biocatalysts for virtually any olefin class.

This framework decouples the delivery of two hydrogen atoms, opening possibilities for regio-, diastereo-, and enantioselective control in alkene hydrogenation–features that have long eluded small-molecule catalysts and may be inaccessible via conventional metal hydride pathways.

BioHAT imports a radical hydrogenation paradigm into biochemistry, enabling asymmetric reduction of unactivated olefins using earth-abundant, iron-containing, genetically encoded catalysts. These enzymes complement, and in some cases rival, state-of-the-art Ir-catalyzed systems.

We evolved enzyme active sites for biocatalytic cooperative metal hydrogen atom transfer (BioHAT) – effectively teaching biology an entirely new way to hydrogenate alkenes, one of the most fundamental transformations in organic chemistry.

Fantastic to meet up with so many former #Arnoldgroup members at the 2025 #ProteinEngineering Gordon conference at Bryant University. #GRC meetings are so great! So is protein engineering.

In a year with so little to cheer about so far, I am happy to share our manuscript on a copper-dependent halogenase. Unbelievable effort by GS Yorick Chiang and Scientist @phdmasao at @uclachem @UclaCBE . Thank you to all collaborators and @NIGMS. https://t.co/fr9cuikhRH

What an honor to be chosen for the Priestley Medal. #Enzymes are the best chemists, of course, but the Priestley medalists are no slouches...and include many of my colleagues @CaltechCCE. Thank you!

Ten Simple Rules for Making Good Oral Presentations (1/2)

My lab https://t.co/OhBVrGEA69 is looking for postdoc candidates eligible for the 2024-25 Fulbright Fellowship https://t.co/xZd9CmGunp @UCLA, we have exciting projects in organic chemistry, biocatalysis, protein engineering and synthetic biology. Eager to hear from you!

Wonderful paper, really shows some disconnect between what academics perceive to be important and focus their teaching efforts on vs what the industry/market needs are. We’ve been thinking about it @uclachem and created a @Ucla_MACS program to address this disconnect.

Check out our work that just appeared in @J_A_C_S on the development of the fastest organometallic Cys bioconjugation reagents: https://t.co/wuBKmpsSm3. Shout out to many @uclachem collaborators on this project including: @group_maynard and @houk1000.

For anyone who has been an academic, this is such a true observation by @a_m_mastroianni

Ideally, should be expressed in E.coli and easily purified. We intend to do mutagenesis studies.

Our collaboration with the Declamp and @jrcaram groups on SWIR Silicon-RosIndolizine fluorophores is now available in @NatureChemistry ! Congrats to Eric, Irene, and the whole team!! 🌟🥳 @uclachem https://t.co/YZPFamO80v

X #biochemistry #proteins #crystallography hive mind, any suggestions for enzymes that can be easily crystallized? Any classical examples? We have some ideas for structural studies for which the specific enzyme does not matter, but ease of getting structures does. DM me!

Expertise in synthetic chemistry and/or protein biochemistry/molecular biology is preferred. @IISERPune @iiserkol @IiserMohali @iiserbhopal @iiscbangalore @iitbombay @IITKanpur @iitmadras @IiserTirupati @iitdelhi @IITKgp