Elmira Khabusheva
@sciencyelmira
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@Goodell_Lab postdoc working on #AML. ex short-term FIMM postdoc. Tweets are my own.
Houston, TX
Joined January 2011
Thrilled to share that my third year as a postdoc in Peggy’s Lab @Goodell_Lab begins with a paper published in @CellCellPress. Forever grateful to @Gandhar_Datar @Goodell_Lab @SuperSciJew for brining me into this incredible collaborative multidisciplinary project.
(1/10) How do diverse leukemia mutations converge on the same molecular program? In our new study @CellCellPress,the @RibackLab and @Goodell_Lab show that disparate mutations rewire shared protein networks to form nuclear condensates called coordinating bodies (C-bodies).🫧
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New paper: Nanoscale domains govern local diffusion and ageing within fused-in-sarcoma condensates Single-molecule tracking reveals nanoscale domains within #FUS #condensates that migrate to the condensate surface during aging, seeding ALS fibrils. https://t.co/pxvUdPGDC5
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Exciting news that two menin inhibitors (revumenib and ziftomenib) are now approved for NPM1-mutant AML! Really cool to see the initial finding from @Armstrong_dfci's lab published in 2016 in @CD_AACR translated all the way to the clinic! https://t.co/fA5oaYpSbv
The @US_FDA approved the menin inhibitor ziftomenib for certain adults with relapsed or refractory acute myeloid leukemia with a susceptible NPM1 mutation and without any alternative treatment options:
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Natural killer cells’ functional impairment drives the immune escape of pre-malignant clones in early-stage myelodysplastic syndromes https://t.co/zZ3jLBzZ0K
#MDSsm @aamdsif @MDSFoundation @ic_MDS @MDS_Hub
nature.com
Nature Communications - Patients with myelodysplastic syndromes (MDS) have limited therapeutic options. Here the authors show that functionally impaired NK cells contribute to immune escape of...
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Now we have a second menin inhibitor approved for R/R NPM1c AML! FDA approves ziftomenib for relapsed or refractory acute myeloid leukemia with a NPM1 mutation #leusm #AMLsm #leukemia
fda.gov
On November 13, 2025, the Food and Drug Administration approved ziftomenib (Komzifti, Kura Oncology, Inc.).
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#FDA approves a treatment for relapsed or refractory acute myeloid leukemia. https://t.co/igJHDdKMlb
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People say, “you become the average of your five closest friends.” But in tissues, a perturbed cell does NOT simply become the average of its nearest neighbors. Sometimes a cell breaks from the crowd. Sometimes signals travel far. Sometimes niches overpower proximity. That is
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Integrated live-cell imaging of LPS-stimulated human blood monocytes revealed that a large % remained viable & contributed negligible IL-1β, while <10% underwent NLRP3 activation, GSDMD pyroptosis, & secreted IL-1β @NatImmunol 🇯🇵🇧🇪 https://t.co/B4777SSm98 Paradigm changing!!
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Regulation of inflammatory responses by pH-dependent transcriptional condensates: Cell
cell.com
BRD4 functions as an intracellular pH sensor through a conserved histidine-rich intrinsically disordered region. Inflammation-associated acidification triggers a pH-dependent switch in transcriptio...
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Epigenetics Update – Reprogramming of H3K36me2 guides lineage-specific post-implantation de novo DNA methylation https://t.co/EFSM7LcbDB
#Epigenetics #DNAm #H3K36me2 #Development --- High-resolution insights without cell sorting; https://t.co/WmSYDGXnzb
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Seeing this for the third time but still amused how beautiful it is!
Epigenetics Update - CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci https://t.co/snmRdlQA5o
#Epigenetics #CRISPR #Chromatin --- Empower your research with high-res epigenetic insights at https://t.co/WmSYDGWPJD
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Huge congrats to Sanju, our co-authors, and our collaborators! Proud to share this work on identifying the mechanisms by which drugs kill cancer through systematic gene KO viability screenings!
Most current drug discovery efforts is structure-based eg. create small molecules or antibodies that best binds X. However, a drug may not drive its efficacy from its strongest binder. Taking a step away from structure-paradigm, we reason that if a CRISPR knockout of a gene
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Our contribution to the field of MDS! Multi-institutional efforts and great collaborations! @VisconteValeria @leukaemielabor @pagliuca_simona @yihong_guan @AwadaHassan_ @babal_jha @MDSFoundation @aamdsif @unitorvergata2 @BloodAdvances
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Loss of MeCP2 results in cGAS-STING-mediated inflammation. Points towards a potential role for cGAS-STING-driven inflammation in Rett syndrome. https://t.co/NY7eJmElAg
nature.com
Nature Communications - Mecp2 deficiency underlies Rett syndrome, a genetic disorder presenting with chronic low-grade inflammation of unknown origin. Here, the authors show that Mecp2 is a central...
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CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci https://t.co/5VtEnCmKEB
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Our new study reveals how hypoxia-induced CTCF drives PRMT5 upregulation to rewire TCF3 splicing, promoting breast cancer invasion and EMT. Congrats to @Mutnuru_SA for key insights into chromatin regulation, splicing & metastasis! Read here: https://t.co/OGCP4fi61e
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Congrats to everyone involved!
🛡️How do macrophages tailor their defenses to different pathogens? Our new paper in @CellSystems combines dense multi-omics time series with high‐content CRISPR screens (CROP-seq) to map the regulatory landscape underlying macrophage immune responses. #Immunity #Screening (1/9)
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Scientists uncover nuclear droplets that link multiple #leukemias revealing new #therapeuticTarget. @Gandhar_Datar @sciencyelmira @Goodell_Lab @RibackLab et al @CellCellPress @BCMGradSchool @bcmhouston
https://t.co/QLZWCs3xAq
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🚨Thrilled to share our latest work, published online today @Nature in which we decipher mechanisms underlying the enigmatic VEXAS syndrome - a huge team effort @MSKCancerCenter led by superstars @VarunNarendraMD + @das_tandrila 🧵1/ https://t.co/0ubLHCbR9I
nature.com
Nature - Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome
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