Josh Riback
@SuperSciJew
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Assistant professor @BCMHouston. Interested in IDPs, RNPs, and LLPS in cells viewed from biophysical chemistry and polymer biophysics. @RibackLab
Houston
Joined July 2009
In lab's #FIRSTPREPRINT, we present methods to measure nanometer organization around & between specific proteins in condensates. We uncover unexpected heterogeneity for a liquid-like phase with local meshwork spanning 10-50nm, stemming from ribosome biogenesis in the nucleolus.
Nanometer condensate organization in live cells derived from partitioning measurements #biorxiv_biophys.
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RT @DNAmyStrom: If heterochromatin is really a liquid-like condensate, why is it not spherical?. We investigated whether mechanical interac….
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RT @DiStefano_Lab: New preprint from the lab! With @Brumbaugh_JB, we show that P-bodies sequester developmentally relevant RNAs to influenc….
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RT @ShorterLab: Nanometer condensate organization in live cells derived from partitioning measurements
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What nanometer structure-function relationships exist in your favorite condensate? We hope you will try to measure it! Congrats to Kris, @Evdokiia_P, Abby, Archish, @Gandhar_Datar, and @SchmitBiophys 4/4.
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In method (2), “Length-Dependent Spatial Coupling," two proteins are linked by variable chains to evaluate their spatial preferences. We determine that scaffold protein NPM1 is 10nm away from ribosome biogenesis, facilitating condensate formation without impairing function. 3/4.
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How? We design 150 protein probes and use thermodynamic principles to interpret their partitioning. In method (1), “Local Size Exclusion,” variable-length amino-acid chains are attached to nucleolar proteins, expelling them based on their local mesh size. 2/4.
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RT @DiStefano_Lab: 1/ Pleased to share our review, published today @NatRevImmunol, highlighting how biomolecular condensates enhance the pr….
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RT @LindorffLarsen: Check out @RasmusNorrild's work with Alex Buell @biophysics_dtu and @JosephRogers100 developing and using Condensate P….
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RT @RNADavid: Why are so many proteins hyper-phosphorylated during mitosis?. Well, phosphorylation renders individual proteins more soluble….
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🎉 Thrilled to share the @ribacklab’s first PhD defense! Huge congrats to @Gandhar_Datar and co-advisor @Goodell_Lab ! 🎓🔬 Gandhar’s work in biophysics and leukemia led to the discovery of a new phase-separated condensate that drives leukemias. Stay tuned for more insights!
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RT @TheSquishyLab: Excited to release our latest work, led by @almcalvo: . Here, we characterize the rich dynamics….
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RT @IvnPla: Collagen-IV networks rule the #mechanics of our epithelia, but we know little about how they reshape. Our new preprint (with th….
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RT @JLeeLab: 1/A picture is worth a thousand words but what if they can say more?! We developed live-cell FLIM approaches to track protein….
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RT @NobelPrize: BREAKING NEWS.The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to….
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RT @RibackLab: Congrats to @BoeynaemsSteven on his lab turning TWO! We enjoy having him and his crew around to share our love of condensate….
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RT @NaturePortfolio: What exactly is a cell type? Ask a dozen researchers and you’ll get as many different answers. A feature in @Nature ou….
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