Puigserver Lab
@puigserver_lab
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Led by Pere Puigserver of @DanaFarber & @HarvardCellBio, our lab studies cellular metabolic and energetic processes
Boston, MA
Joined August 2019
Potential health benefits of cold-water immersion: the central role of PGC-1α (open access) https://t.co/IQTokh60tT
physoc.onlinelibrary.wiley.com
Abstract figure legend Cold-water immersion (CWI) elicits autonomic, somato-motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may...
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Victoria Sánchez Perez and Adam S. Crystal chaired a plenary session on "Synthetic Lethality" this morning at #Targets25, featuring Edmond M. Chan, Peter S. Hammerman, Francisca Vazquez, and William Sellers. @DrFranVazquez
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Chaperone-mediated autophagy stabilizes PGC1α, influencing energy metabolism. Lamp2a knockdown in mice BAT increases PGC1α, boosting metabolism. Insights into thermal stress! PMID:40360527, Nat Commun 2025, @NatureComms
https://t.co/Pxis3pLnny
#AI #Pharma #BioMed #RNA #ASHG #ESHG
nature.com
Nature Communications - Thermogenic proteins like PGC1α are downregulated under thermal stress, but the underlying mechanisms are unclear. Here, the authors show that chaperone-mediated...
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If you can only attend a handful of meetings next year, @CellSymposia #CSMito2026 should be a priority. It offers a comprehensive, top-to-bottom perspective on mitochondria, and brings together a diverse group of scientists from across the field. Visit: https://t.co/TUlucMVPlu
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If you can only attend a handful of meetings next year, @CellSymposia #CSMito2026 should be a priority. It offers a comprehensive, top-to-bottom perspective on mitochondria, and brings together a diverse group of scientists from across the field. Visit: https://t.co/MvNDCoQkEZ
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❤️Our October issue is out❤️Read about the RNA editing enzyme ADAR1 regulating atherosclerosis progression, PGC-1α and cardiac adaptation to exercise training, the role of LYVE1-macrophages in heart regeneration and peripheral artery disease, and more. https://t.co/6IDTiQSHE7
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7/9) Nuance note: The researchers also found that PGC1α, the master regulator of mitochondrial biogenesis, was a key player. Artificially boosting PGC1α in the fathers’ muscles was enough to replicate the benefits in the offspring, though the exact link between muscle PGC1α and
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New! Online now: Paternal exercise confers endurance capacity to offspring through sperm microRNAs https://t.co/qD1eentGzQ
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Check out the latest paper from the Spiegelman lab that we collaboratored on looking into the role of cardiac PGC1a in adaptations to exercise. Congrats to Sumeet and all the other co-authors!
Cardiac PGC1a is required for adaptations of the heart to exercise (in mice). A wonderful collaboration with the lab of Tony Rosenzweig. Sumeet is off to start his won lab at UVa (congrats!)
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Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia
nature.com
Nature Cancer - Using multiple in vivo mouse models, Rehman and colleagues report that tumor-induced impairments in the muscle vasculature mediated by circulating activin A contribute to cachexia...
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A great line-up of speakers for Cell Symposia Multifaceted Mitochondria June 2026 in Glasglow! Check it out and register early: https://t.co/ObqLxNCAlJ
@KivancBirsoy @RutterLab @jourdainlab and more! #mitochondria @CellPressNews
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A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons: Cell
cell.com
Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to...
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#CIBseminars Mechanisms of mitochondrial adaptive respiration Pedro Latorre Muro, Dana-Farber Cancer Institute/Harvard Medical School, Boston, MA (USA) 📆July 17 ⏰15pm Online seminar. Registration required 🔗 https://t.co/sOM9HFzQvJ
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PGC-1α–mediated phospholipid synthesis plays a pivotal role in BAT thermogenesis in a sex-dependent manner in mice revealing a new therapeutic target for metabolic diseases in postmenopausal women.
nature.com
Nature Communications - Brown adipose tissue (BAT) plays a role in energy expenditure but its thermogenic activities differ between sexes. Here, the authors show that PGC-1α enhances...
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Thanks Tom and Jonathan! @DFCI_CancerBio
@puigserver_lab
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New preview just published in Molecular Cell! We highlight exciting work by Chen et al. identifying an arginine sensing axis mediated by BAG2 and SAMD4B that promotes survival under arginine deficiency. https://t.co/m71gz29mUv
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Thrilled to share that I’ll be starting my new position as a tenure-track assistant professor at the @OSU Comprehensive Cancer Center on July 1st! And to continue my journey to conquer cancer through the lens of metabolism and immunity.
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Thanks from my deep heart to @puigserver_lab @PpuigserverB, Kai Wucherpfennig, Hans Widlund, Jean Zhao, and everyone at @DFCI_CancerBio and @harvardmed for your mentorship and support. Excited for what’s ahead!
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Pan & colleagues identified a novel role of #PVSC-derived #PGC-1α in regulating #PVAT plasticity & the pathogenesis of #aneurysms. Learn more at https://t.co/PfA6r6OEwa
@CVR_TomaszGuzik
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A vascular perspective on #cancer cachexia here restoring endothelial PGC1α activity preserved vascular density and muscle mass in tumor-bearing mice @NatureCancer
nature.com
Nature Cancer - Using multiple in vivo mouse models, Rehman and colleagues report that tumor-induced impairments in the muscle vasculature mediated by circulating activin A contribute to cachexia...
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