🧵 Endogenous DMT: What Do We Really Know? Two recent papers shed new light on endogenous DMT, its biosynthesis, regulation, and function: 📄 Exploring DMT: Endogenous Role and Therapeutic Potential – by @psychedmt 📄 N,N-Dimethyltryptamine (DMT) in Rodent Brain: Concentrations,

Gotta admire the storytelling in this fresh Nature paper! Adenosine is the culprit behind ketamine and ECT antidepressant actions. Acute hypoxia also works. At least for mice in a beaker. https://t.co/fefRQ4F3WS

⚠️ Photosensitivity Warning: 5-MeO-DMT Replication by @VisionSymmetric

Well done, Natalie and co!

The drugs disrupt the link between vascular and neuronal activity, which complicates interpretations of fMRI data. https://t.co/ZLhBlGEryd

wow

“The rotating waves act like herders that steer the cortex back to the correct computational path” #Neuroscience Work led by @BatabyalTamal

Decoding the rhythmic representation and communication of visual contents https://t.co/HkL6fo9JQJ #neuroscience

Sleep and psychedelics reveal different bifurcations, yet the same system topology. In both, the brain nears a phase-transition boundary, where stability weakens and new modes of neural organization emerge. Different dynamics, same geometry of mind.

Congratulations to lead authors @Alex_Attinger and @ADrinnenberg from the @KarlDeisseroth lab and all our fantastic collaborators! Check out the thread below for new work on plasticity, the cortex and spatial representations for navigation!

Neuropharmacology of halogenated DMT analogs: psychoplastogenic and antidepressant properties of 5-Br-DMT, a psychedelic derivative with low hallucinogenic potential https://t.co/dE39HCmzWg

This is exciting...5-MeO-DMT just got FDA breakthrough designation for treatment resistant depression. 193 ppl with moderate-to-severe depression 38 sites 6 countries Patients received either 12 mg (n=73), 8 mg (n=46), or a low-dose comparator of 0.3 mg (n=74), which served as

How does our brain excel at complex object recognition, yet get fooled by simple illusory contours? What unifying principle governs all Gestalt laws of perceptual organization? We may have an answer: integration of learned priors through feedback. New paper with Ken Miller! 🧵

Discovery of Highly Selective 5-HT2A Agonists Using Structure-Guided Design | Journal of Medicinal Chemistry

Scopolamine's Anticholinergic Effects on EEG Spectral, Aperiodic, Complexity, Microstates, and Heart Rate Variability - Chen - 2025 - Human Psychopharmacology: Clinical and Experimental - Wiley Online Library

TAAR 1 regulates presynaptic dopamine function: evidence from preclinical studies and a phase 1b trial in patients with schizophrenia https://t.co/1QOe73MzYJ

Great piece by Tamlin Magee for BBC celebrates the many unsung contributions of https://t.co/MYclFAMKyj to drug policy, culture and science & interviews psychedelic nerds like myself, @erik_davis, @RickDoblin, @LeorRoseman, & @NicolasLanglitz

Dopamine & Learning Debunked https://t.co/RAVpRtYLEE @NatureNeuro @NeuroscienceNew @Neuro_Skeptic @TheLancetNeuro @leafs_s @KordingLab @drmichaellevin @anilkseth @Mark_Solms @behaviOrganisms @rlai_lab @EcoTheoryRL @HrlTeam @DrTomFroese @WiringTheBrain @IntuitMachine @HenryYin19

Neurons transmit signals through synaptic vesicle release, but the nanoscale dynamics of this process have been unclear. In a new Science study, researchers report using time-resolved cryo–electron tomography to visualize synaptic vesicle dynamics in situ and propose a unified

New paper: Working memory readout varies with frontal theta rhythms. A theta traveling wave swept across the frontal cortex like radar, modulating working memory performance. Because cognition is rhythmic. https://t.co/nmCcINu3ef #neuroscience @MIT_Picower @mitbrainandcog @MIT

Major news for mental health research — the FDA has granted Breakthrough Therapy status to a 5-MeO-DMT nasal spray developed by Atai Life Sciences and Beckley Psytech.