Jakub Schimmelpfennig
@psychedmt
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First steps as #psychedelics (DMT) and #consciousness researcher. Chief of Psychedelic and Consciousness Research Group on @SWPSUniversity Neuropsychology 🧠🍄
Warsaw
Joined January 2022
🧵 Endogenous DMT: What Do We Really Know?.Two recent papers shed new light on endogenous DMT, its biosynthesis, regulation, and function:.📄 Exploring DMT: Endogenous Role and Therapeutic Potential – by @psychedmt .📄 N,N-Dimethyltryptamine (DMT) in Rodent Brain: Concentrations,
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RT @breath_Guy: Neurobiological substrates of altered states of consciousness induced by high ventilation breathwork accompanied by music.
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RT @CankayKoryak: 🧠Complex systems do not work like classical computers. They don’t follow strict logic or fixed output. They thrive at th….
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RT @RCarhartHarris: Very grateful to be included here. Psilocybin inducing high-freq oscillations (100Hz) in freely-moving rats: https://t.….
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Fascinating work on cortical destabilization as a common signature of anesthesia. Many consciousness studies quantify neural activity with information-theoretic metrics (entropy, Lempel-Ziv complexity, PCI, etc.) @RCarhartHarris, while DeLASE focuses on dynamical stability.
New results! Similar destabilization of neural dynamics under different general anesthetics.Different anesthetics induce unconsciousness through distinct mechanisms, but cortical destabilization may be their common effect. #neuroscience.
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RT @leafs_s: Nature Communications . Phase synchrony between prefrontal noradrenergic and cholinergic signals indexes inhibitory control.ht….
nature.com
Nature Communications - The role of norepinephrine (NE) and acetylcholine (ACh) signaling in the cognitive control of impulsivity remains unclear. Here, the authors reveal that impulse control...
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RT @MillerLabMIT: (link fixed) New theory: Categorization is Baked Into the Brain.It is not at the end of sensory processing. It's comput….
osf.io
Categorization, the grouping of similar objects, actions, or events, is fundamental to adaptive behavior. Traditionally, neuroscience assumes it begins with feature detection following to, as a final...
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This new paper unifies measures of high-order interdependence. While not about psychedelics directly, it matters: psychedelic neuroscience often relies on entropy, but these tools let us ask a deeper question: do altered states foster redundancy or synergy in brain dynamics?.
Finally published:.“Characterising high-order interdependence via entropic conjugation”. The final version includes findings on similarities in the high-order profiles of spin systems and early music supporting a new characterisation of the O-information!.
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RT @PTenigma: 🔥CAN YOU MAP BLOOD FLOW in the brain from resting state fMRI? .🔥Ingenious new method [1] learns from jointly collected ASL (a….
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RT @RogerSeheult: Having good health is not just to live longer. "When health is absent, wisdom cannot reveal itself, strength cannot fi….
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RT @BellevueDoc: Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple scleros….
pmc.ncbi.nlm.nih.gov
Multiple sclerosis (MS) is a debilitating neurodegenerative disease characterized by demyelination and neuronal loss. Traditional therapies often fail to halt disease progression or reverse neurolo...
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Resting-state fMRI reveals recurrent attractor-like states. In MDD, a salience-dominated state occurs more often with shorter dwell times, linked to anhedonia. Transitions show reduced flexibility between cognitive–affective systems and costly detours along inefficient structural.
"Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity".
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RT @RCarhartHarris: Psychedelics and the Brain: Unlocking New Possibilities for Healing via @YouTube Grateful to my….
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RT @ArgelAV: Serotonin and psilocybin activate 5-HT1B receptors to suppress cortical signaling through the claustrum | Nature Communication….
nature.com
Nature Communications - Our basic understanding of neuromodulation in the claustrum remains limited. Here Madden et al., identify a key mechanism by which serotonin and the psychedelic psilocybin...
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RT @MillerLabMIT: Inside the search for a universal signature of unconsciousness."Neuroscientists like Earl K. Mill….
bigthink.com
A universal marker of unconsciousness could transform both medicine and our understanding of the mind.
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RT @EricTopol: How your brain's metabolic waste products get cleared during sleep, featuring the pivotal 2012 discovery of glymphatics @sci….
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microdosing 🍄.
@hubermanlab @sweatystartup @RCarhartHarris Therapeutic effects might be real but so far the credible research suggests they COULD be 100 % driven by placebo effects. Binded studies show increased acute positive mood but that can also be construed as abuse liability. Anyone microdosing should consider the potential risk of.
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