Julie Holland, MD
@BellevueDoc
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psychiatrist, author, wife/mom, musician, MDMA & cannabis researcher, harm reductionist, medical advisor to MAPS ++, GOOD CHEMISTRY: The Science of Connection.
New York
Joined March 2009
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It is about goddamn time. 25th Ammendment. Unfit for office. (also, vote him out.)
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Addiction is giving up everything for one thing.
Recovery is giving up one thing for everything.
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THIS WILL BE THE THIRD TIME, if I’m not mistaken, that there will have been a recommendation to the DEA to make cannabis schedule three. Twice they have refused. If they do it again, I will say it again : Abolish the DEA.
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"Cannabis halves the risk for the development of diabetes mellitus type 2"
The meta-analysis of 7 studies (11 surveys and 4 cohorts) revealed that the odds are 0.48 times lower than in those without cannabis exposure.
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For those of you who know him, or care about his plight, or wrote letters on his behalf as I did, William Leonard Pickard is being released, compassionately.
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Cannabinoids inhibit liver toxicity of alcohol:
In a study with rats, cannabinoids were shown to inhibit the toxicity of alcohol to the liver.
Clinical Experimental Centre, Shaanxi Province, China.
Yan L, et al. J Biochem Mol Toxicol. 2022 Dec 1:e23260.
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@bessbell
@JenaFriedman
I tell my patients who are pregnant that it is important to read books on breast-feeding and to take a class if possible. We all read books about delivery but the truth is your body will do what it needs to if you get out of its way. Nursing requires more education +support.
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Today MAPS has submitted
MDMA-Assisted Therapy for PTSD
to the FDA.
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"Microdosing LSD increases the complexity of your brain signals"
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DSM has added a new diagnosis: Prolonged Grief Disorder. There should b no timeline on feeling whole again (they put it at a year), but I'd ask researchers to consider using MDMA assisted therapies for this new classification. Or psilocybin assisted therapy. Or LSD. Or ayahuasca.
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I told ya! Runner's high is due to endocannabinoid system, not opiate/endorphin. They gave naltrexone, an opiate receptor antagonists to runners, and they still got "high."
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Psychedelics induce neuroplasticity resembling the effects of clinically approved antidepressants, which bind to TrkB, the receptor for BDNF. LSD and psilocin directly bind to TrkB with affinities 1,000 fold higher than those for antidepressants.
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PSA: San Pedro cactus also has mescaline and grows more commonly, and much more quickly, and it is not endangered like peyote.
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Repeated ayahuasca use increases structural covariance in networks associated with ‘self’ processing
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Seriously a dream come true:
the UCLA study is happening!
(the NY version will also be happening, but not quite yet)
FDA Approves MDMA for Clinical Trial Use Investigating Schizophrenia via @
@Pharmacy_Times
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More on cannabis and psychosis:
Authors noted that “there was no significant association between any measure of cannabis use at baseline and either transition to psychosis, the persistence of symptoms, or functional outcome.”
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Psilocybin-induced changes in neural reactivity to alcohol and emotional cues in patients with alcohol use disorder: an fMRI pilot study
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another university opening up another psychedelic research center. good for us all.
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"who knows why we were taught to fear the witches, and not those who burned them alive."
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DEA calls for the increased production of psychedelics: (up from last month)
8000 grams of psilocybin, 11,000 grams of 5-MeO-DMT, 12,000 grams of MDMA, 12,000 grams of MDA, and 5,100 grams of 2-CB.
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shortly after a state adopts recreational cannabis legalization, they experience a decrease in the average number of mental health treatment admissions.
Ortega A. Health Econ. 2023 Jun 30. [in press]
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@MollieKatzen
@RVAwonk
yeah... I was watching it live. I'm always amazed at how little *content* is in Trump's speech. classic lying, talking circles, not saying anything real, putting it back on the other person in the conversation. so painful to watch. my son would say "cringey"
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Stilbenes of the cannabis plant may have anti-inflammatory and anti-cancer effects
14 stilbenes have been identified to be present in cannabis.
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Please tell me I'm not the first one to notice this:
healTHCare
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Psilocybin in Palliative Care:
Research and field reports reviewed suggest that psilocybin has significant and in some cases, sustained anxiolytic, antidepressant, anti-inflammatory and entheogenic effects with a favorable safety profile.
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oh psychedelics, what can't you do? first psychological issues, then traumatic brain injury, now pain?
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cannabidivarin (CBDV). it's gonna be a thing. anti-inflammatory, epilepsy, autism spectrum disorders...
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"boring but important":
AMA approved a new CPT code for psychedelic-assisted therapies. This enables billing, and potentially insurance reimbursement, etc.
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meta analysis on cannabis and schizophrenia:
"no causal relationship can be inferred from the current results. The findings could be in favor of both a detrimental and beneficial effect of cannabis on positive and negative symptoms, respectively"
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1) higher dose thc can have psychedelic effects, and could likely be used as an adjunct to psychotherapy (or a way to "process trauma") the way some are using mdma or psilocybin
2) maybe stop fetishizing single strains of cannabis and consider a blend
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Turns out my new book is already on Amazon for pre-orders. Good Chemistry comes out this June... chock full of information about MDMA, cannabis, and psychedelics like psilocybin and LSD. But mostly, it's a book about oxytocin and oneness.
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"Find the others"
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Kill Your Lawn, Before It Kills You!
"While the lawn may be a powerful symbol of American postwar prosperity, it’s also an ecological dead zone that’s sucking the nation’s aquifers dry."
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Medical cannabis study after three months clinical:
"may be effective in reducing both pain severity and pain interference while also improving quality of life, general health, mood and sleep in patients with chronic pain."
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Psychedelics bare and heal, heart and soul. They also help elucidate invaluable information about the brain, its chemistry, circuitry, and plasticity.
#ThankYouPlantMedicine
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Cognitive effects of psilocybin:
increased ratings of spontaneous creative insights +
decreased deliberate task-specific creativity. Novel ideas increased 7 days after the psilocybin exposure. Brain imaging supported the behavioral changes in creativity.
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CBD + CBG may protect healthy skin cells from the effect of UVA radiation
preventing healthy cells from damage by UVA-radiation without significantly reducing its therapeutic effect on skin diseases such as psoriasis
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psychedelics for brain injury, this paper, people!
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We are in dire need of psychiatric treatments which dismantle the powerful grip of shame, and offer hope and meaning in its place. The daily dose is no longer cutting it. Clearly heart opening medicines have arrived. My patients deserve better. My friends deserve better.
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Meta-analysis of 126 papers on psilocybin, ayahuasca, mdma, lsd
reviews efficacy and safety in treating psychiatric disorders/psychological complaints
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Ibogaine (plus magnesium) for traumatic brain injury study (yes, there is no placebo control group. doesn't matter. ibogaine works. better than anything so far. the issue is the cardiac risk.)
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Two months after treatment, 67 percent of participants in the MDMA group no longer qualified for a diagnosis of PTSD, compared with 32 percent in the placebo group.
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psychedelics as anti-inflammatory
Efficacy is sub-behavioral.
Psychedelics can both prevent and rescue inflammation in human disease models.
Anti-inflammatory efficacy is not correlated with behavioral potency or canonical signaling.
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Effects of DMT on mental health outcomes in healthy volunteers
Changes in depression and trait anxiety correlated with acute peak experiences ("Oceanic Boundlessness")
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John Oliver does a tremendous job on psychedelic assisted therapy
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TIME on MDMA-assisted couples therapy.
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Iceland Psychedelics as Medicine conference. January 12-13. With
@MichaelPollan
@RickDoblin
@KelseyRamsden
@BenSessa
@dr_brein
I will happily be there soon! can't wait.
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"These findings suggest that psychedelics have the capacity to elicit a connection with nature that is passionate and protective, even among those who were not previously nature oriented."
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In a pilot study by Harvard Medical School + Hannover Medical School, 100 percent of the patients reported significant relief from cluster headaches in the 4-month-period they were tracked after receiving 3 doses of BOL-148, a non-psychedelic LSD derivative Ceruvia Life Sciences
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Who's going to tell the New Yorker (usually meticulous in their fact checking) that MDMA was never called the name "Therapy" but rather "Adam" and also "Empathy" briefly, before being called "Ecstasy" (and now "Molly") ?
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Psychedelic U offers a starting point for those new to psychedelics and for experienced psychonauts alike.
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Lots of info here.
Mescaline lasting longer than LSD. Mescaline and LSD, but not psilocybin, enhancing circulating oxytocin. None of them increasing BDNF.
32 Ss random/double/placebo/xover
Needs replication, of course, and rethinking by me.
Leichti again.
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American Medical Association (AMA) has approved a Current Procedural Terminology CPT code for those seeking reimbursement for psychedelic therapies.
The full details are expected in July 2023.
The code(s) will go into effect January 1, 2024.
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Effects of Psychedelic Microdosing versus Conventional ADHD Medication Use on Emotion Regulation, Empathy, and ADHD Symptoms in Adults with severe ADHD
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Psychedelic Assembly (NYC) is creating a library/bookstore/café. This will be a membership-driven meeting space for psychonauts and those who love them, complete with events, book readings, signings, and other "find the others" gatherings. Wanna help?
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If those valentines chocolates contain "magic mushrooms". -- set and setting matter (safe space, heads in a good place), pick a lane (don't add alcohol), and sadly, until our drug policy changes, buyer beware, also micro doses and museum doses likely lovelier than heroic ones imo
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High CBD cannabis for migraines:
"a combination of 6% THC and 11% CBD performed the best and was able to provide a significant improvement on the main endpoint of pain relief two hours after a migraine attack."
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proud to be on this list, but man... so many men! Where are the psychedelic women?
After weeks of collecting information and data, Psychedelic Invest is proud to release the 100 Most Influential People in Psychedelics
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very gratifying to see an article in Nature about something I've been yammering about for decades (MDMA and psilocybin for the field of psychiatry). it's coming, people.
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Doing a morning show dealie with Kelly and Ryan, tomorrow morning. but no Kelly :(
9:40 am talking about psychedelics and Good Chemistry.
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Legalization of cannabis for medical and recreational use in the US was not associated with any increase in psychosis diagnoses/claims.
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@MollyJongFast
@TheRickWilson
@MilesTaylorUSA
@thedailybeast
Anytime you want to talk about the psychopathology and drugs that are fueling this behavior, please know an entertaining psychiatrist/ psychopharmacologist is standing at the ready.
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Why I call them psychedelics:
What's so "hallucinogenic" about peace, love, and understanding?
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More than a dozen activists staged a “die-in” outside the Drug Enforcement Administration (DEA) headquarters in Arlington, Va., Monday, demanding the agency allow patients with life-threatening conditions to legally access psilocybin. 17 were arrested.
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Psychedelic-occasioned mystical experiences linked to increased pro-environmental behaviors
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8,000 cups of pee can't be wrong:
Using results from 800k urine tests, researchers found less opiates when cannabis also present
Reduced urinary opioid levels from pain management patients associated with marijuana use.
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Who Are You After Psychedelics? A Systematic Review and a Meta-Analysis of the Magnitude of Long-Term Effects of Serotonergic Psychedelics on Cognition/Creativity, Emotional Processing and Personality
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She is not the only doctor I know doing this.
"Cancer-care expert Dr. Diana Martins-Welch finds herself in an unusual position: Last week she started telling her medical marijuana patients to quit vaping cannabis and pick up a joint instead."
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I like to fantasize about certain politicians availing themselves of MDMA-assisted therapy, psilocybin and ayahuasca...so they may clearly see the cycle of traumatized and traumatizer... and perhaps neuroplasticity-enabled behavioral change would follow?
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Connecticut governor Ned Lamont signed a tax bill that includes a pilot program to provide psychedelic-assisted therapy, using MDMA and psilocybin, to qualifying veterans, retired first-responders, and frontline workers such as police and firefighters.
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full article on the potential for using psychedelics in the treatment of chronic pain
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I'm no 'founder' but I am a 'charter member,' knowing Rick before MAPS was formed.
Throwback to the MAPS conference last month with the lovely founders
@BellevueDoc
and
@RickDoblin
! 🧠💭 This year’s conference was a blast!
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@jessicashortall
@bessbell
@JenaFriedman
I was talking about the need for educating oneself about nursing versus educating oneself about delivery. Women focus on educating themselves about delivery and forget that nursing is not completely intuitive and requires education. I’m sorry if I was unclear.
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Psychedelic experiences may contribute to an increase in psychological flexibility and reduction in racial trauma symptoms and alcohol and drug use among POC (who've been largely excluded from psychedelic treatment research)
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pain reduction in PTSD with chronic pain following MDMA-assisted therapy.
whole article
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Like I said at last year's Horizons (when I was interviewing Michael Pollan) cannabis *does* activate the 5HT2A "psychedelic" receptor:
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Naturalistic Psilocybin Use is Associated with Persisting Improvements in Mental Health and Wellbeing
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The amount of peyote consumption is higher than the rate of regrowth. Please consider san pedro as an alternate source of mescaline.
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Biden's brother says the president is 'very open-minded' about psychedelics for medical treatment
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Psilocybin pulse regimen reduces cluster headache attack frequency in the blinded extension phase of a randomized controlled trial.
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30 years ago, 1988: DEA Administrative Law Judge Francis Young rules, after thorough hearings, that cannabis has clearly established medical use and should be reclassified as a prescription drug. His recommendation is ignored.
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Whaaaa— just was asked to interview Melissa Ethridge at Denver MAPS2023. Did I say yes? Reader, I did.
June 22. Be there!!
#psychedelicscience2023
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In 2023, Oregon will become the first U.S. state to offer psilocybin services, and Colorado’s Initiative 58 could make that state a close second. Six training programs have been approved:
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Psychedelic-assisted therapy entails supporting people through their most vulnerable states and darkest moments, and as such, the ethical responsibility of this work cannot be overstated.
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...dinner with the family, each of us talking about different drugs we like/have tried, and whether they involved ego dissolution or not. 10/10 would recommend.
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cannabis use "not associated with apathy, effort-based decision-making for reward, reward wanting, or reward liking in adults or adolescents. Cannabis users had lower anhedonia than controls"
No amotivation syndrome found.
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Hey… I finally passed 10,000 followers and I am not foolin’
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In a study with mice the combination of CBD and ketamine showed good antidepressant-like effects without unwanted side effects.
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MDMA-assisted therapy is associated with a reduction in chronic pain among people with post-traumatic stress disorder.
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well, this is a first.
Reschedule Cannabis Or 'Abolish The DEA,' Says Physician: Examining The 50-Year-Old, Trillion-Dollar Agency via
@Benzinga
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Just got this in the mail, and I read the foreword, and it’s actually pretty good! This is an amazing book, and I am very proud of Amanda Siebert for putting it all together.
@amanda_siebert
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Volunteer to be in a study of MDMA assisted psychotherapy for the treatment of PTSD. Multiple sites in CA, NY, CO, Boston, NOLA, SC, WI.
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PsPsilocybin for dementia prevention? The potential role of psilocybin to alter mechanisms associated with major depression and neurodegenerative diseases
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I want to understand the pharmacology of eye movements.
(think EMDR, eye rolling with MDMA, occulogyric crisis with antipsychotics).
Who knows about this? what should I read?
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"candy flipping" (MDMA + LSD) clinical study announced:
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