BryanRoth
@zenbrainest
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James Black: 'the prismatic qualities of the assay distort our view in obscure ways and degrees'
Here, now.
Joined November 2013
Congrats to the team: especially @gori7873 and Brian Krumm from @RothLabUNC and Adrien and Matan from Greg Scherrer's lab!! A ton of work! Structure-guided design of a peripherally restricted chemogenetic system: Cell
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Wow!!!
HUGE story in private biotech world! Arena BioWorks, an ambitious biomedical institute backed by billionaires, abruptly shuts down https://t.co/JqKzxGTVQy via @ADeAngelis_bio
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Great review of chemogenetics: https://t.co/E4RrIggH1b
nature.com
Molecular Psychiatry - Advances in chemogenetics: a review of DREADDs and its application in psychiatric disorders
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Great review of chemogenetics: https://t.co/E4RrIggH1b
nature.com
Molecular Psychiatry - Advances in chemogenetics: a review of DREADDs and its application in psychiatric disorders
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Delighted to share our comprehensive study elucidating the intrinsic-bias encoded in the complement anaphylatoxin receptor system 😎!!! Molecular mechanism of naturally-encoded signaling-bias at the complement anaphylatoxin receptors
biorxiv.org
The conceptual framework of biased signaling has revolutionized our understanding of GPCR signaling and regulatory paradigms, and greatly impacted the efforts focused on the discovery of GPCR-targe...
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Not entirely useless…but don’t take tooo seriously. I use them to guide my interrogation of the relevant literature
Automated gene ontology terms are the laziest, misleadingest, futilest thing ever devised in the history of biology.
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Lots of amazing science happening @BeckmanIllinois! Whether your interests are in molecules or minds, you will be amazed by our innovative, interdisciplinary research. Give us a follow to learn about our latest news, events, and employment and fellowship opportunities!!🔸🔬🧠🧪🔹
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Happy to share our paper creating an atlas of the dendritic morphology of D1- and D2-MSNs and elucidating its organizational principle. Thanks to Chris Park, Ming Yan, Masood Akram, Hongwei Dong, Daniel Tward, and others. Funding from US BRAIN Initiative.
nature.com
Nature Neuroscience - The authors mapped the dendritic morphology of thousands of striatal D1-type and D2-type medium spiny neurons in healthy and Huntington’s disease mouse brains, revealing...
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🚨Applications are now open for 2026 @BeckmanIllinois Postdoctoral Fellowships! We provide 3 years of support ($63k/year) for candidates conducting interdisciplinary research with two or more Beckman faculty members. Please apply and RT!
beckman.illinois.edu
The Beckman Institute at the University of Illinois at Urbana-Champaign offers three postdoctoral fellow programs to support outstanding scientists: Beckman Institute Postdoctoral Fellows Program,...
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As someone with Connexin-26 (GJB2) mutations, I've managed to so far study most forms of hearing loss that do NOT involve GJB2. As a cell biologist, I've managed to study ER-organelle related processes and disorders with minimal connection to hearing loss. Now this paper drops.
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1/ Announcing we have raised $4.2M led by @cbventures and @alliancedao. We’re building the first fully-fledged Trading Terminal on @base and launching our new cash back program.
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Nascent proteins may be phosphorylated during translation, and the phosphosite buried in the protein’s inner core. Such buried phosphosites are found in ~ 1/3 of the phosphorylated human proteins. Buried phosphosites can influence protein abundance (👇), providing another
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Delighted to share our latest study on atypical activation and dimerization of an intrinsically-biased chemokine receptor, CXCR7! Atypical activation and molecular glue-like dimerization mechanism of an intrinsically-biased chemokine receptor
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A ventral pallidal glutamatergic aversive network encodes abstinence from and reexposure to cocaine | Science Advances
science.org
Cocaine abstinence and reexposure generate permanent changes in specific ventral pallidal glutamatergic outputs.
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My parting words to all my scientific friends in Germany as I head home.
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My parting words to all my scientific friends in Germany as I head home.
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Wow!!
Very excited to see this out in final form! Big congratulations to @JonAMichaels for driving this project forward over the past five years.
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