Yuval Nir 💔
@LabNir
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Studying sleep, anesthesia, neuromodulation, memory, and sensory processing, combining human and animal models, Tel Aviv University | @labnir.bsky.social
Joined February 2019
1/14 How does sleep help memory? we developed closed-loop deep brain stimulation during sleep in human prefrontal cortex w/ timing based on hippocampal activity TLDR: boosting hippocampus-cortex coordination improves memory @NatureNeuro | https://t.co/z4Ixoi86sg
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Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics https://t.co/NWotcLULaN
nature.com
Nature Neuroscience - Yang et al. show that moments of failed attention we experience after sleep deprivation reflect brief ‘sleep-like’ episodes in the brain, corresponding to a brain-...
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Falling asleep follows a predictable bifurcation dynamic https://t.co/sNczDSuyuX
nature.com
Nature Neuroscience - Li et al. propose a conceptual framework to study the phenomenon of falling asleep based on electroencephalogram data. They show that a tipping point marks the brain’s...
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Head-direction cells as a neural compass in bats navigating outdoors on a remote oceanic island | Science
science.org
Animals and humans rely on their navigation skills to survive. However, spatial neurons in the brain’s “navigation circuit” had not previously been studied under real-world conditions. We conducted...
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Convergent Control of NREM Sleep and Anesthesia by Prefrontal Layer 5 Extratelencephalic Neurons
biorxiv.org
The cortical mechanisms that actively suppress consciousness remain poorly understood. Here, we identify a specific subset of prefrontal cortical (PFC) neurons preferentially active under anesthesia...
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Proud and delighted to deliver the keynote presentation at “Sleep Down Under 2025” Adelaide, organized by the Australasian Sleep Association @asa_nest @SleepOrgANZ #SDU2025 #SleepDownUnder
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Arousal as a universal embedding for spatiotemporal brain dynamics: https://t.co/VpJgfWDWY8
nature.com
Nature - Reframing of arousal as a latent dynamical system can reconstruct multidimensional measurements of large-scale spatiotemporal brain dynamics on the timescale of seconds in mice.
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Join Prof. Dr Marcello Massimini at #eSleepEurope2025 as he explores “Local sleep and the emergence of sleep-like activity in specific states such as brain damage.” ➡️ 9 October, 13:00–13:45 CEST 🔗 Register here: https://t.co/opHG8gAzq5
#eSleepEurope2025 #ESRS
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A new study shows that a small cluster of neurons called the locus coeruleus has a specialized pathway to the brainstem that controls sound-evoked awakening with the release of norepinephrine. @LabNir @NMatosevich
https://t.co/b1s6gzKVSr
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@NMatosevich @SinaKabaha @MarmelAm @NoamGabay Thanks to alumni and colleagues for valuable feedback and inputs @HannaCattan, Yaniv Sela, @inna_slutsky @OferYizhar 🙏
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(6/6) ✨ Take-home: LC neurons are not a single unitary arousal system. LC→PRN brainstem pathway is critical for sound-evoked awakening Thanks to team and colleagues 🙌 led by amazing @NMatosevich , Noa Regev, U. Kimchi, N. Zelinger, @SinaKabaha, @MarmelAm & @NoamGabay
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(5/6) What happens if you silence LC synapses? Using an optoGPCR (PdCO), we found that shutting down LC→PRN boosts sigma power and deepens NREM sleep. Silencing both PRN + BF was even more effective.
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(4/6) Timing is everything ⏱️ Optogenetic activation showed that sound-evoked awakening depends on which LC neurons are active AND when they fire - synchrony with the sound is key.
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(3/6) Here’s the twist: only the LC→PRN pathway shows a fast NE surge when sounds are played during sleep. That rapid signal predicts whether the sound will wake the mouse.
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(2/6) Not all LC pathways are the same 👀 We compared LC projections to the basal forebrain (BF) and to the brainstem pontine reticular nucleus (PRN). They turned out to be partially distinct populations.
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🚨 New paper alert! 🚨(1/6) Excited to share our work, out now in Science Advances We show that a rapid norepinephrine surge along a brainstem pathway (LC→PRN) is a key driver of sound-evoked awakenings https://t.co/O9q4qWOmzR
science.org
The locus coeruleus has a specialized pathway to the brainstem that controls sound-evoked awakening from sleep.
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Aperiodic EEG Activity Provides a Linear, Bidirectional, and Spatially Uniform Marker of Subjective and Objective Vigilance in Humans, Both Within and Across States
biorxiv.org
Vigilance is increasingly conceived as a continuum, ranging from full alertness to deep sleep. Despite its fundamental role in cognition, behaviour, and health, reliable physiological markers of...
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Sleep-like slow waves during wakefulness uncover a malignant form of Parkinson’s disease
medrxiv.org
Slow waves during sleep are fundamental for neural homeostasis, metabolic regulation, and waste clearance, and are known to be altered in neurodegenerative diseases. Sleep-like slow waves (SLSW) have...
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Nature research paper: Rate and noise in human amygdala drive increased exploration in aversive learning https://t.co/yHEoOymyAc
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Human hippocampal ripples align new experiences with a grid-like schema: Neuron
cell.com
Xiao et al. show that brief bursts of hippocampal activity (ripples) help the brain link new experiences into an internal “mental map.” During rest, ripples engage a medial frontal brain region that...
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