bioRxiv Molecular Biology
@biorxiv_molbio
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Joined August 2022
Structural reorganization underlying stress-induced cytoplasmicsolidification in yeast https://t.co/n2cWCz0xld
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Cells employ diverse strategies to rapidly adapt to sudden environmental changes. In yeast, cytoprotective solidification in response to starvation and energy depletion (ED) has been reported and...
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Ligand-Induced Structural Dynamics Drive Allosteric Regulation of Translation Initiation Factor eIF4E https://t.co/hqz2sRrLQg
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The eukaryotic initiation factor 4E (eIF4E) governs cap-dependent translation and its dysregulation contributes both to cancer and neurological disorders, making it an attractive target for therape...
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An upstream secondary DNA motif within the IL3 insulator CTCF binding site is required for enhancer-blocking insulator activity https://t.co/yLard1eDP9
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CCCTC-binding Factor (CCTF) is the only known vertebrate protein that functions to organise the genome into distinct functional chromatin domains. A subset of CTCF sites also provide insulator...
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A new class of proteinaceous biomaterial with unprecedented properties in unicellular eukaryotes https://t.co/RAzEVas2WI
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Biomaterials fundamentally reshape material use, providing superior properties and sustainable alternatives relevant to medicine, textiles, and high-tech applications. Research mainly focuses on...
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A panel of CYP6Z genes drives broad-spectrum cross-resistance to public health insecticides in the major malaria vector An. gambiae s.s. https://t.co/j3VGCdJ4lE
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The spread of multiple and intense insecticide resistance in major African malaria vectors is jeopardising control efforts. Mitigating this threat requires deciphering its underlying molecular...
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Transcriptome-wide mapping reveals an RNA-dependent mechanism of platinum cancer drugs. https://t.co/tin7zzh51o
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Small molecules developed to target proteins or DNA may also bind RNA, but the extent and biological significance of such interactions among oncology drugs remain poorly defined. Here, we systemati...
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Recombinant Laccase Production Causes Alterations of the S. cerevisiae Proteome that are Dependent on the Strain Origins https://t.co/qxg9F1Wahf
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Saccharomyces cerevisiae yeast is a widely used recombinant protein production host. Recombinant protein expression requires adaptation of the host cell proteome to accommodate recombinant expressi...
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The transcription of a single olfactory receptor per neuron is enforced by epigenetic silencing of their enhancers https://t.co/ahQrKvqJTE
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The ability to discriminate thousands of odors in our environment requires each olfactory neuron to express a single olfactory receptor from hundreds of available genes. The biochemical mechanism...
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Copy Number Variation-Based Molecular Sexing of Ixodes scapularis and Rhipicephalus microplus Immature Stages Using qPCR and ddPCR ... https://t.co/bjSMe4SVc5
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Accurate sex identification of immature ticks is essential for understanding sex-specific ecological dynamics, pathogen transmission, and reproductive biology. However, tick larvae and nymphs lack...
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Epitranscriptomic landscape of vascular smooth muscle cell phenotypic transitions highlights uridine RNA modifications associated ... https://t.co/22PxlDghYc
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Background: Vascular smooth muscle cells (VSMCs) reside in the medial arterial wall and are involved in the regulation of vascular tone and remodeling. VSMCs possess phenotypic plasticity, contribu...
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The role of the VirB ligand CTP in the molecular mechanism of transcriptional anti-silencing in Shigella flexneri https://t.co/TxuxBfMsTh
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In bacteria, nucleoid-structuring proteins bind and constrain DNA, often leading to transcriptional silencing. In Shigella spp ., the histone-like nucleoid-structuring protein H-NS silences many...
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Microgravity Remodels Longevity Networks in Astronaut PBMCs: Integrated Findings of Telomere Elongation, DNA Repair Responses, and ... https://t.co/5BNkHA2rFj
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Microgravity provides a unique environment for elucidating the fundamental mechanisms of human aging. In the Microgravity Associated Genetics (MESSAGE) Science Mission, Turkiye's first human space...
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From storms to warming seas: a long-term metabarcoding survey in port communities unveils high genetic diversity and ecological ... https://t.co/jkpRba8FLs
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Ports are key gateways for the introduction and spread of non-indigenous species (NIS), yet the ecological and genetic temporal dynamics of these introductions remain poorly understood. Long term...
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Proteolytic Control of an Auto-inhibitory Intrinsically Disordered Region Governs Small RNA Selectivity in Argonaute Proteins https://t.co/8CwjAVlB9Z
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Argonaute proteins are central to small RNA-mediated gene regulation, yet the mechanisms controlling their activity remain incompletely understood. We elucidate a novel regulatory mechanism governing...
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tBid mediated genetic ablation of connective tissue cells reveal their key regulatory function during limb regeneration in axolotls https://t.co/d5sq2L6s0T
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Limb regeneration in adulthood is a fascinating phenomenon unique to salamanders, requiring precise coordination and interaction of various cell types. Connective tissue (CT) constitutes a major...
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RNA polymerase II initiation factors show different dynamic behaviour upon induced transcription in live cells https://t.co/9ApyvCCKe3
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Transcription by RNA polymerase II (Pol II) requires the ordered action of general transcription factors (GTFs) forming the pre‑initiation complex (PIC). How these events unfold kinetically remains...
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Conserved RNA helicase Vasa regulates ribonucleoprotein condensates through protein interaction and mRNA recruitment https://t.co/ayrMHmtoMa
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Germlines contain ribonucleoprotein condensates known as germ granules, which concentrate proteins and mRNAs essential for animal development. Vasa, a conserved DEAD-box RNA helicase, is a core and...
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Multicenter HFpEF study identifies sex disparity linked with two discrete cardiac proteomic signatures https://t.co/8dZnA6GAW1
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Heart failure with preserved ejection fraction (HFpEF) is epidemic, with an incidence exceeding that of heart failure with reduced ejection fraction (HFrEF). Sex differences in HFpEF phenotype have...
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Structural and Computational Analysis of Pseudomonas Aeruginosa DNA Gyrase Reveals Molecular Characteristics That May Contribute to ... https://t.co/aWdlCVHZ2i
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Pseudomonas aeruginosa is considered a priority pathogen by the World Health Organization due to its resistance to antibiotics. Isolates resistant to ciprofloxacin (CPFX), a bactericide commonly used...
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HypoxamicroRNA-210 protects against hepatic steatosis by inhibiting CIDEC expression https://t.co/oqFO0ERfBB
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Background and Aims Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major global health burden. Although hypoxia is known to contribute to MASLD pathogenesis, the role of...
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